Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.
Identifieur interne : 000D09 ( Ncbi/Checkpoint ); précédent : 000D08; suivant : 000D10Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease.
Auteurs : Brigitte Piallat [France] ; Mircea Polosan ; Valérie Fraix ; Laurent Goetz ; Olivier David ; Albert Fenoy ; Napoleon Torres ; Jean-Louis Quesada ; Eric Seigneuret ; Pierre Pollak ; Paul Krack ; Thierry Bougerol ; Alim L. Benabid ; Stéphan ChabardèsSource :
- Annals of neurology [ 1531-8249 ] ; 2011.
English descriptors
- KwdEn :
- Action Potentials (physiology), Adult, Aged, Female, Functional Laterality (physiology), Humans, Imaging, Three-Dimensional (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neurons (physiology), Obsessive-Compulsive Disorder (pathology), Parkinson Disease (pathology), Subthalamic Nucleus (pathology).
- MESH :
- methods : Imaging, Three-Dimensional, Magnetic Resonance Imaging.
- pathology : Obsessive-Compulsive Disorder, Parkinson Disease, Subthalamic Nucleus.
- physiology : Action Potentials, Functional Laterality, Neurons.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder.
DOI: 10.1002/ana.22222
PubMed: 21520240
Affiliations:
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pubmed:21520240Le document en format XML
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In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L" last="Benabid">Alim L. 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