Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus
Identifieur interne : 002D36 ( Main/Exploration ); précédent : 002D35; suivant : 002D37Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus
Auteurs : Michael W. M. Schüpbach [France] ; Marie Laure Welter [France] ; Anne Marie Bonnet [France] ; Alexis Elbaz [France] ; Brandon R. Grossardt [États-Unis] ; Valerie Mesnage [France] ; Jean Luc Houeto [France] ; David Maltête [France] ; Luc Mallet [France] ; Walter A. Rocca [États-Unis] ; Alain Mallet [France] ; Yves Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Aged, Cause of Death, Cognition Disorders (diagnosis), Deep Brain Stimulation (methods), Deep brain stimulation, Female, Follow-Up Studies, Human, Humans, Male, Middle Aged, Mortality, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (epidemiology), Parkinson Disease (mortality), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Postoperative Period, Predictive Value of Tests, Subthalamic Nucleus (physiology), Subthalamic nucleus, Survival Rate, Treatment, deep brain stimulation, mortality, subthalamic nucleus.
- MESH :
- diagnosis : Cognition Disorders.
- epidemiology : Parkinson Disease.
- methods : Deep Brain Stimulation.
- mortality : Parkinson Disease.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Cause of Death, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Postoperative Period, Predictive Value of Tests, Survival Rate.
Abstract
Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short‐term mortality is low, but little is known about long‐term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow‐up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6–4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7–2.1). © 2006 Movement Disorder Society
Url:
- https://api.istex.fr/document/EA1D52661A896691A6735B4F14F20977CE49D3CD/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00177234
DOI: 10.1002/mds.21264
Affiliations:
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Le document en format XML
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<term>Aged</term>
<term>Cause of Death</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Deep brain stimulation</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
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<term>Parkinson Disease (mortality)</term>
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<term>Parkinson's disease</term>
<term>Postoperative Period</term>
<term>Predictive Value of Tests</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic nucleus</term>
<term>Survival Rate</term>
<term>Treatment</term>
<term>deep brain stimulation</term>
<term>mortality</term>
<term>subthalamic nucleus</term>
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<term>Survival Rate</term>
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<term>Mortalité</term>
<term>Noyau sousthalamique</term>
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<front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short‐term mortality is low, but little is known about long‐term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow‐up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6–4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7–2.1). © 2006 Movement Disorder Society</div>
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