Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.
Identifieur interne : 001985 ( Ncbi/Checkpoint ); précédent : 001984; suivant : 001986Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.
Auteurs : Michael W M. Schüpbach [France] ; Marie Laure Welter ; Anne Marie Bonnet ; Alexis Elbaz ; Brandon R. Grossardt ; Valerie Mesnage ; Jean Luc Houeto ; David Maltête ; Luc Mallet ; Walter A. Rocca ; Alain Mallet ; Yves Agid [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Cause of Death, Cognition Disorders (diagnosis), Deep Brain Stimulation (methods), Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (epidemiology), Parkinson Disease (mortality), Parkinson Disease (therapy), Postoperative Period, Predictive Value of Tests, Subthalamic Nucleus (physiology), Survival Rate.
- MESH :
- diagnosis : Cognition Disorders.
- epidemiology : Parkinson Disease.
- methods : Deep Brain Stimulation.
- mortality : Parkinson Disease.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Cause of Death, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Postoperative Period, Predictive Value of Tests, Survival Rate.
Abstract
Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).
DOI: 10.1002/mds.21264
PubMed: 17149702
Affiliations:
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pubmed:17149702Le document en format XML
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<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
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<author><name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R" last="Grossardt">Brandon R. Grossardt</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Deep Brain Stimulation (methods)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (mortality)</term>
<term>Parkinson Disease (therapy)</term>
<term>Postoperative Period</term>
<term>Predictive Value of Tests</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Survival Rate</term>
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<term>Aged</term>
<term>Cause of Death</term>
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<front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</div>
</front>
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<tree><noCountry><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne Marie" last="Bonnet">Anne Marie Bonnet</name>
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<name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R" last="Grossardt">Brandon R. Grossardt</name>
<name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean Luc" last="Houeto">Jean Luc Houeto</name>
<name sortKey="Mallet, Alain" sort="Mallet, Alain" uniqKey="Mallet A" first="Alain" last="Mallet">Alain Mallet</name>
<name sortKey="Mallet, Luc" sort="Mallet, Luc" uniqKey="Mallet L" first="Luc" last="Mallet">Luc Mallet</name>
<name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name>
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<name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A" last="Rocca">Walter A. Rocca</name>
<name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie Laure" last="Welter">Marie Laure Welter</name>
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<country name="France"><noRegion><name sortKey="Schupbach, Michael W M" sort="Schupbach, Michael W M" uniqKey="Schupbach M" first="Michael W M" last="Schüpbach">Michael W M. Schüpbach</name>
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