Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.
Identifieur interne : 000044 ( Hal/Corpus ); précédent : 000043; suivant : 000045Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.
Auteurs : Michael Schüpbach ; Marie-Laure Welter ; Anne-Marie Bonnet ; Alexis Elbaz ; Brandon Grossardt ; Valerie Mesnage ; Jean-Luc Houeto ; David Maltête ; Luc Mallet ; Walter Rocca ; Alain Mallet ; Yves AgidSource :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
Abstract
Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).
Url:
DOI: 10.1002/mds.21264
Links to Exploration step
Hal:inserm-00177234Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.</title>
<author><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"><orgName>Neuroépidémiologie</orgName>
<desc><address><addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U708" active="#struct-300002" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U708" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Grossardt, Brandon" sort="Grossardt, Brandon" uniqKey="Grossardt B" first="Brandon" last="Grossardt">Brandon Grossardt</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-94149" status="VALID"><orgName>Department of Health Sciences Research [Mayo Clinic]</orgName>
<orgName type="acronym">HSR</orgName>
<desc><address><addrLine>Mayo Clinic 200 First Street SW Rochester, MN 55905 USA</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://mayoresearch.mayo.edu/hsr/index.cfm</ref>
</desc>
<listRelation><relation active="#struct-310910" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-310910" type="direct"><org type="institution" xml:id="struct-310910" status="VALID"><orgName>Mayo Clinic</orgName>
<desc><address><country key="US"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valerie" last="Mesnage">Valerie Mesnage</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
</author>
<author><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Mallet, Luc" sort="Mallet, Luc" uniqKey="Mallet L" first="Luc" last="Mallet">Luc Mallet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Rocca, Walter" sort="Rocca, Walter" uniqKey="Rocca W" first="Walter" last="Rocca">Walter Rocca</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-94149" status="VALID"><orgName>Department of Health Sciences Research [Mayo Clinic]</orgName>
<orgName type="acronym">HSR</orgName>
<desc><address><addrLine>Mayo Clinic 200 First Street SW Rochester, MN 55905 USA</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://mayoresearch.mayo.edu/hsr/index.cfm</ref>
</desc>
<listRelation><relation active="#struct-310910" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-310910" type="direct"><org type="institution" xml:id="struct-310910" status="VALID"><orgName>Mayo Clinic</orgName>
<desc><address><country key="US"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Mallet, Alain" sort="Mallet, Alain" uniqKey="Mallet A" first="Alain" last="Mallet">Alain Mallet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-15366" status="VALID"><orgName>Service de biostatistiques et information médicale</orgName>
<desc><address><addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-300887" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"><orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300887" type="direct"><org type="institution" xml:id="struct-300887" status="INCOMING"><orgName>Hôpital Pitié-Salpêtrière</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00177234</idno>
<idno type="halId">inserm-00177234</idno>
<idno type="halUri">http://www.hal.inserm.fr/inserm-00177234</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00177234</idno>
<idno type="doi">10.1002/mds.21264</idno>
<date when="2007-01-15">2007-01-15</date>
<idno type="wicri:Area/Hal/Corpus">000044</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.</title>
<author><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3066" status="OLD"><orgName>Neuroépidémiologie</orgName>
<desc><address><addrLine>GH Pitie-Salpetriere 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U708" active="#struct-300002" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U708" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Grossardt, Brandon" sort="Grossardt, Brandon" uniqKey="Grossardt B" first="Brandon" last="Grossardt">Brandon Grossardt</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-94149" status="VALID"><orgName>Department of Health Sciences Research [Mayo Clinic]</orgName>
<orgName type="acronym">HSR</orgName>
<desc><address><addrLine>Mayo Clinic 200 First Street SW Rochester, MN 55905 USA</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://mayoresearch.mayo.edu/hsr/index.cfm</ref>
</desc>
<listRelation><relation active="#struct-310910" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-310910" type="direct"><org type="institution" xml:id="struct-310910" status="VALID"><orgName>Mayo Clinic</orgName>
<desc><address><country key="US"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valerie" last="Mesnage">Valerie Mesnage</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
</author>
<author><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Mallet, Luc" sort="Mallet, Luc" uniqKey="Mallet L" first="Luc" last="Mallet">Luc Mallet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Rocca, Walter" sort="Rocca, Walter" uniqKey="Rocca W" first="Walter" last="Rocca">Walter Rocca</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-94149" status="VALID"><orgName>Department of Health Sciences Research [Mayo Clinic]</orgName>
<orgName type="acronym">HSR</orgName>
<desc><address><addrLine>Mayo Clinic 200 First Street SW Rochester, MN 55905 USA</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://mayoresearch.mayo.edu/hsr/index.cfm</ref>
</desc>
<listRelation><relation active="#struct-310910" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-310910" type="direct"><org type="institution" xml:id="struct-310910" status="VALID"><orgName>Mayo Clinic</orgName>
<desc><address><country key="US"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Mallet, Alain" sort="Mallet, Alain" uniqKey="Mallet A" first="Alain" last="Mallet">Alain Mallet</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-15366" status="VALID"><orgName>Service de biostatistiques et information médicale</orgName>
<desc><address><addrLine>47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation active="#struct-300068" type="direct"></relation>
<relation active="#struct-300887" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300068" type="direct"><org type="institution" xml:id="struct-300068" status="VALID"><orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300887" type="direct"><org type="institution" xml:id="struct-300887" status="INCOMING"><orgName>Hôpital Pitié-Salpêtrière</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-3037" status="VALID"><orgName>Neurologie et thérapeutique expérimentale</orgName>
<desc><address><addrLine>GH Pitié-Salpetrière 47, Boulevard de L'Hopital 75651 PARIS CEDEX 13</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u289.ifrns.chups.jussieu.fr/</ref>
</desc>
<listRelation><relation active="#struct-93591" type="direct"></relation>
<relation name="U679" active="#struct-300002" type="direct"></relation>
<relation active="#struct-300636" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="VALID"><orgName>Université Pierre et Marie Curie - Paris 6</orgName>
<orgName type="acronym">UPMC</orgName>
<desc><address><addrLine>4 place Jussieu - 75005 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.upmc.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U679" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300636" type="direct"><org type="institution" xml:id="struct-300636" status="VALID"><orgName>IFR70</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1002/mds.21264</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2007-01-15</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.</title>
<author role="aut"><persName><forename type="first">Michael</forename>
<forename type="middle">W.</forename>
<surname>Schüpbach</surname>
</persName>
<email></email>
<idno type="halauthor">214474</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<email></email>
<idno type="halauthor">214475</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Anne-Marie</forename>
<surname>Bonnet</surname>
</persName>
<email></email>
<idno type="halauthor">214476</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexis</forename>
<surname>Elbaz</surname>
</persName>
<email>elbaz@chups.jussieu.fr</email>
<idno type="halauthor">214201</idno>
<affiliation ref="#struct-3066"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Brandon</forename>
<forename type="middle">R.</forename>
<surname>Grossardt</surname>
</persName>
<email></email>
<idno type="halauthor">214234</idno>
<affiliation ref="#struct-94149"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valerie</forename>
<surname>Mesnage</surname>
</persName>
<email></email>
<idno type="halauthor">214477</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jean-Luc</forename>
<surname>Houeto</surname>
</persName>
<email></email>
<idno type="halauthor">214478</idno>
</author>
<author role="aut"><persName><forename type="first">David</forename>
<surname>Maltête</surname>
</persName>
<email></email>
<idno type="halauthor">214479</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Luc</forename>
<surname>Mallet</surname>
</persName>
<email></email>
<idno type="halauthor">214480</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Walter</forename>
<forename type="middle">A.</forename>
<surname>Rocca</surname>
</persName>
<email>rocca@mayo.edu</email>
<idno type="halauthor">214220</idno>
<affiliation ref="#struct-94149"></affiliation>
<affiliation ref="#struct-45655"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alain</forename>
<surname>Mallet</surname>
</persName>
<email></email>
<idno type="halauthor">200837</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="crp"><persName><forename type="first">Yves</forename>
<surname>Agid</surname>
</persName>
<email>agid@ccr.jussieu.fr</email>
<idno type="halauthor">214481</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<editor role="depositor"><persName><forename>Christophe</forename>
<surname>Tzourio</surname>
</persName>
<email>tzourio@chups.jussieu.fr</email>
</editor>
</titleStmt>
<editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2007-10-05 18:13:45</date>
<date type="whenModified">2015-01-19 11:49:49</date>
<date type="whenReleased">2007-10-05 19:16:11</date>
<date type="whenProduced">2007-01-15</date>
<date type="whenEndEmbargoed">9999-12-31</date>
<ref type="file" target="http://www.hal.inserm.fr/inserm-00177234/document"><date notBefore="9999-12-31"></date>
</ref>
<ref type="file" n="1" target="http://www.hal.inserm.fr/inserm-00177234/file/14.pdf"><date notBefore="9999-12-31"></date>
</ref>
</edition>
<respStmt><resp>contributor</resp>
<name key="118702"><persName><forename>Christophe</forename>
<surname>Tzourio</surname>
</persName>
<email>tzourio@chups.jussieu.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt><distributor>CCSD</distributor>
<idno type="halId">inserm-00177234</idno>
<idno type="halUri">http://www.hal.inserm.fr/inserm-00177234</idno>
<idno type="halBibtex">schupbach:inserm-00177234</idno>
<idno type="halRefHtml">Movement Disorders, Wiley, 2007, 22 (2), pp.257-61. <10.1002/mds.21264></idno>
<idno type="halRef">Movement Disorders, Wiley, 2007, 22 (2), pp.257-61. <10.1002/mds.21264></idno>
</publicationStmt>
<seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
<idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno>
<idno type="stamp" n="APHP" p="INSERM">AP-HP</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
</seriesStmt>
<notesStmt><note type="audience" n="2">International</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
</notesStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.</title>
<author role="aut"><persName><forename type="first">Michael</forename>
<forename type="middle">W.</forename>
<surname>Schüpbach</surname>
</persName>
<idno type="halAuthorId">214474</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<idno type="halAuthorId">214475</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Anne-Marie</forename>
<surname>Bonnet</surname>
</persName>
<idno type="halAuthorId">214476</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexis</forename>
<surname>Elbaz</surname>
</persName>
<email>elbaz@chups.jussieu.fr</email>
<idno type="halAuthorId">214201</idno>
<affiliation ref="#struct-3066"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Brandon</forename>
<forename type="middle">R.</forename>
<surname>Grossardt</surname>
</persName>
<idno type="halAuthorId">214234</idno>
<affiliation ref="#struct-94149"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valerie</forename>
<surname>Mesnage</surname>
</persName>
<idno type="halAuthorId">214477</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jean-Luc</forename>
<surname>Houeto</surname>
</persName>
<idno type="halAuthorId">214478</idno>
</author>
<author role="aut"><persName><forename type="first">David</forename>
<surname>Maltête</surname>
</persName>
<idno type="halAuthorId">214479</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Luc</forename>
<surname>Mallet</surname>
</persName>
<idno type="halAuthorId">214480</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Walter</forename>
<forename type="middle">A.</forename>
<surname>Rocca</surname>
</persName>
<email>rocca@mayo.edu</email>
<idno type="halAuthorId">214220</idno>
<affiliation ref="#struct-94149"></affiliation>
<affiliation ref="#struct-45655"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alain</forename>
<surname>Mallet</surname>
</persName>
<idno type="halAuthorId">200837</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="crp"><persName><forename type="first">Yves</forename>
<surname>Agid</surname>
</persName>
<email>agid@ccr.jussieu.fr</email>
<idno type="halAuthorId">214481</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
</analytic>
<monogr><idno type="halJournalId" status="VALID">17211</idno>
<idno type="issn">0885-3185</idno>
<idno type="eissn">1531-8257</idno>
<title level="j">Movement Disorders</title>
<imprint><publisher>Wiley</publisher>
<biblScope unit="volume">22</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="pp">257-61</biblScope>
<date type="datePub">2007-01-15</date>
</imprint>
</monogr>
<idno type="doi">10.1002/mds.21264</idno>
<idno type="pubmed">17149702</idno>
</biblStruct>
</sourceDesc>
<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><classCode scheme="mesh">Adult</classCode>
<classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Neuropsychological Tests</classCode>
<classCode scheme="mesh">Parkinson Disease</classCode>
<classCode scheme="mesh">Postoperative Period</classCode>
<classCode scheme="mesh">Predictive Value of Tests</classCode>
<classCode scheme="mesh">Subthalamic Nucleus</classCode>
<classCode scheme="mesh">Survival Rate</classCode>
<classCode scheme="mesh">Cause of Death</classCode>
<classCode scheme="mesh">Cognition Disorders</classCode>
<classCode scheme="mesh">Deep Brain Stimulation</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">Follow-Up Studies</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
<classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</abstract>
</profileDesc>
</hal>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Hal/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000044 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000044 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Hal |étape= Corpus |type= RBID |clé= Hal:inserm-00177234 |texte= Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus. }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |