MovDisordV3, Hal, Curation, bibRecord, 000044

Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.

Identifieur interne : 000044 ( Hal/Curation ); précédent : 000043; suivant : 000045

Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.

Auteurs : Michael Schüpbach [France] ; Marie-Laure Welter [France] ; Anne-Marie Bonnet [France] ; Alexis Elbaz [France] ; Brandon Grossardt [États-Unis] ; Valerie Mesnage [France] ; Jean-Luc Houeto ; David Maltête [France] ; Luc Mallet [France] ; Walter Rocca [États-Unis] ; Alain Mallet [France] ; Yves Agid [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-01-15.

RBID : Hal:inserm-00177234

Abstract

Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).

Url:

http://www.hal.inserm.fr/inserm-00177234

DOI: 10.1002/mds.21264

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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<idno type="DOI">10.1002/mds.21264</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2007-01-15</date>
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<front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.</title>
<author role="aut"><persName><forename type="first">Michael</forename>
<forename type="middle">W.</forename>
<surname>Schüpbach</surname>
</persName>
<email></email>
<idno type="halauthor">214474</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<email></email>
<idno type="halauthor">214475</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Anne-Marie</forename>
<surname>Bonnet</surname>
</persName>
<email></email>
<idno type="halauthor">214476</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexis</forename>
<surname>Elbaz</surname>
</persName>
<email>elbaz@chups.jussieu.fr</email>
<idno type="halauthor">214201</idno>
<affiliation ref="#struct-3066"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Brandon</forename>
<forename type="middle">R.</forename>
<surname>Grossardt</surname>
</persName>
<email></email>
<idno type="halauthor">214234</idno>
<affiliation ref="#struct-94149"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valerie</forename>
<surname>Mesnage</surname>
</persName>
<email></email>
<idno type="halauthor">214477</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jean-Luc</forename>
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<email></email>
<idno type="halauthor">214478</idno>
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<author role="aut"><persName><forename type="first">David</forename>
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<idno type="halauthor">214479</idno>
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<author role="aut"><persName><forename type="first">Luc</forename>
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<email></email>
<idno type="halauthor">214480</idno>
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</author>
<author role="aut"><persName><forename type="first">Walter</forename>
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<email>rocca@mayo.edu</email>
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<affiliation ref="#struct-94149"></affiliation>
<affiliation ref="#struct-45655"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alain</forename>
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</persName>
<email></email>
<idno type="halauthor">200837</idno>
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</author>
<author role="crp"><persName><forename type="first">Yves</forename>
<surname>Agid</surname>
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<email>agid@ccr.jussieu.fr</email>
<idno type="halauthor">214481</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<editor role="depositor"><persName><forename>Christophe</forename>
<surname>Tzourio</surname>
</persName>
<email>tzourio@chups.jussieu.fr</email>
</editor>
</titleStmt>
<editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2007-10-05 18:13:45</date>
<date type="whenModified">2015-01-19 11:49:49</date>
<date type="whenReleased">2007-10-05 19:16:11</date>
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<surname>Tzourio</surname>
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<email>tzourio@chups.jussieu.fr</email>
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<idno type="halRefHtml">Movement Disorders, Wiley, 2007, 22 (2), pp.257-61. <10.1002/mds.21264></idno>
<idno type="halRef">Movement Disorders, Wiley, 2007, 22 (2), pp.257-61. <10.1002/mds.21264></idno>
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<seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
<idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno>
<idno type="stamp" n="APHP" p="INSERM">AP-HP</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
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<notesStmt><note type="audience" n="2">International</note>
<note type="popular" n="0">No</note>
<note type="peer" n="1">Yes</note>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.</title>
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<author role="aut"><persName><forename type="first">Brandon</forename>
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<author role="aut"><persName><forename type="first">Luc</forename>
<surname>Mallet</surname>
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<idno type="halAuthorId">214480</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Walter</forename>
<forename type="middle">A.</forename>
<surname>Rocca</surname>
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<email>rocca@mayo.edu</email>
<idno type="halAuthorId">214220</idno>
<affiliation ref="#struct-94149"></affiliation>
<affiliation ref="#struct-45655"></affiliation>
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<author role="aut"><persName><forename type="first">Alain</forename>
<surname>Mallet</surname>
</persName>
<idno type="halAuthorId">200837</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="crp"><persName><forename type="first">Yves</forename>
<surname>Agid</surname>
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<email>agid@ccr.jussieu.fr</email>
<idno type="halAuthorId">214481</idno>
<affiliation ref="#struct-3037"></affiliation>
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<monogr><idno type="halJournalId" status="VALID">17211</idno>
<idno type="issn">0885-3185</idno>
<idno type="eissn">1531-8257</idno>
<title level="j">Movement Disorders</title>
<imprint><publisher>Wiley</publisher>
<biblScope unit="volume">22</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="pp">257-61</biblScope>
<date type="datePub">2007-01-15</date>
</imprint>
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<idno type="doi">10.1002/mds.21264</idno>
<idno type="pubmed">17149702</idno>
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<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><classCode scheme="mesh">Adult</classCode>
<classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Neuropsychological Tests</classCode>
<classCode scheme="mesh">Parkinson Disease</classCode>
<classCode scheme="mesh">Postoperative Period</classCode>
<classCode scheme="mesh">Predictive Value of Tests</classCode>
<classCode scheme="mesh">Subthalamic Nucleus</classCode>
<classCode scheme="mesh">Survival Rate</classCode>
<classCode scheme="mesh">Cause of Death</classCode>
<classCode scheme="mesh">Cognition Disorders</classCode>
<classCode scheme="mesh">Deep Brain Stimulation</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">Follow-Up Studies</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
<classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</abstract>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.

Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.

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