Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus
Identifieur interne : 001581 ( PascalFrancis/Checkpoint ); précédent : 001580; suivant : 001582Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus
Auteurs : Michael W. M. Schupbach [France] ; Marie Laure Welter [France] ; Anne Marie Bonnet [France] ; Alexis Elbaz [France] ; Brandon R. Grossardt [États-Unis] ; Valerie Mesnage [France] ; Jean Luc Houeto [France] ; David Maltete [France] ; Luc Mallet [France] ; Walter A. Rocca [États-Unis] ; Alain Mallet [France] ; Yves Agid [France]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).
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Pascal:07-0133256Le document en format XML
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<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
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<front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</div>
</front>
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<fA03 i2="1"><s0>Mov. disord.</s0>
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</fA05>
<fA06><s2>2</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>SCHUPBACH (Michael W. M.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>WELTER (Marie Laure)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>BONNET (Anne Marie)</s1>
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<fA11 i1="04" i2="1"><s1>ELBAZ (Alexis)</s1>
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<fA11 i1="05" i2="1"><s1>GROSSARDT (Brandon R.)</s1>
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<fA11 i1="06" i2="1"><s1>MESNAGE (Valerie)</s1>
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<fA11 i1="07" i2="1"><s1>LUC HOUETO (Jean)</s1>
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<fA11 i1="08" i2="1"><s1>MALTETE (David)</s1>
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<fA11 i1="09" i2="1"><s1>MALLET (Luc)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>ROCCA (Walter A.)</s1>
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<fA11 i1="11" i2="1"><s1>MALLET (Alain)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>AGID (Yves)</s1>
</fA11>
<fA14 i1="01"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and National Institute of Health and Medical Research (INSERM) Unit 679 (former Unit 289), Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>National Institute of Health and Medical Research (INSERM) Unit 708 (former Unit 360), Hôpital de la Salpêtrière</s1>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Health Sciences Research, Mayo Clinic College of Medicine</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurology, Mayo Clinic College of Medicine</s1>
<s2>Rochester, Minnesota</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Biostatistics and Medical Information, Pitié-Salpêtrière Medical University</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA20><s1>257-261</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000145528070210</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>28 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0133256</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17F</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
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<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Mortalité</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Mortality</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Mortalidad</s0>
<s5>09</s5>
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<s5>10</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Human</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Traitement</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Treatment</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>11</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>12</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Subthalamic nucleus</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
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<s5>40</s5>
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<s5>40</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>41</s5>
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<fN21><s1>085</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
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</pA>
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<li>États-Unis</li>
</country>
<region><li>Minnesota</li>
<li>Île-de-France</li>
</region>
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<name sortKey="Mallet, Luc" sort="Mallet, Luc" uniqKey="Mallet L" first="Luc" last="Mallet">Luc Mallet</name>
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<name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie Laure" last="Welter">Marie Laure Welter</name>
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<country name="États-Unis"><region name="Minnesota"><name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R." last="Grossardt">Brandon R. Grossardt</name>
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