MovDisordV3, Main, Exploration, bibRecord, 002D37

Morphometric changes of sensorimotor structures in focal dystonia

Identifieur interne : 002D37 ( Main/Exploration ); précédent : 002D36; suivant : 002D38

Morphometric changes of sensorimotor structures in focal dystonia

Auteurs : Mark Obermann [Allemagne] ; Ozguer Yaldizli [Allemagne] ; Armin De Greiff [Allemagne] ; Martin Lenard Lachenmayer [Allemagne] ; Anna Rebecca Buhl [Allemagne] ; Felicitus Tumczak [Allemagne] ; Elke Ruth Gizewski [Allemagne] ; Hans-Christoph Diener [Allemagne] ; Matthias Maschke [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-06-15.

RBID : ISTEX:09540BE5AD2D8AE73ABAB2C67E300EC9D590B8FF

Descripteurs français

Pascal (Inist)
- Blépharospasme, Dystonie, Intégration, Morphométrie, Noyau gris central, Système nerveux pathologie, Torticolis, Voxel.

English descriptors

KwdEn :
- Adult, Aged, Basal Ganglia (pathology), Basal Ganglia (physiopathology), Basal ganglion, Blepharospasm, Blepharospasm (drug therapy), Blepharospasm (epidemiology), Blepharospasm (physiopathology), Botulinum Toxins, Type A (therapeutic use), Caudate Nucleus (pathology), Caudate Nucleus (physiopathology), Dystonia, Dystonic Disorders (drug therapy), Dystonic Disorders (epidemiology), Dystonic Disorders (physiopathology), Female, Humans, Integration, Magnetic Resonance Imaging, Male, Middle Aged, Morphometry, Nervous system diseases, Neuromuscular Agents (therapeutic use), Psychomotor Disorders (drug therapy), Psychomotor Disorders (epidemiology), Severity of Illness Index, Torticollis, Torticollis (drug therapy), Torticollis (epidemiology), Torticollis (physiopathology), Voxel, basal ganglia., blepharospasm, cervical dystonia, focal dystonia, sensorimotor integration, torticollis, voxel‐based morphometry.
MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Blepharospasm, Dystonic Disorders, Psychomotor Disorders, Torticollis.
- epidemiology : Blepharospasm, Dystonic Disorders, Psychomotor Disorders, Torticollis.
- pathology : Basal Ganglia, Caudate Nucleus.
- physiopathology : Basal Ganglia, Blepharospasm, Caudate Nucleus, Dystonic Disorders, Torticollis.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index.

Abstract

Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel‐based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this stdy was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age‐ and gender‐matched controls. High‐resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/09540BE5AD2D8AE73ABAB2C67E300EC9D590B8FF/fulltext/pdf

DOI: 10.1002/mds.21495

Affiliations:

Allemagne

Le document en format XML

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<term>Aged</term>
<term>Basal Ganglia (pathology)</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Basal ganglion</term>
<term>Blepharospasm</term>
<term>Blepharospasm (drug therapy)</term>
<term>Blepharospasm (epidemiology)</term>
<term>Blepharospasm (physiopathology)</term>
<term>Botulinum Toxins, Type A (therapeutic use)</term>
<term>Caudate Nucleus (pathology)</term>
<term>Caudate Nucleus (physiopathology)</term>
<term>Dystonia</term>
<term>Dystonic Disorders (drug therapy)</term>
<term>Dystonic Disorders (epidemiology)</term>
<term>Dystonic Disorders (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Integration</term>
<term>Magnetic Resonance Imaging</term>
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<term>Middle Aged</term>
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<term>Torticollis (epidemiology)</term>
<term>Torticollis (physiopathology)</term>
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<term>basal ganglia.</term>
<term>blepharospasm</term>
<term>cervical dystonia</term>
<term>focal dystonia</term>
<term>sensorimotor integration</term>
<term>torticollis</term>
<term>voxel‐based morphometry</term>
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<term>Dystonic Disorders</term>
<term>Psychomotor Disorders</term>
<term>Torticollis</term>
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<front><div type="abstract" xml:lang="en">Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel‐based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this stdy was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age‐ and gender‐matched controls. High‐resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin. © 2007 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Morphometric changes of sensorimotor structures in focal dystonia

Morphometric changes of sensorimotor structures in focal dystonia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.