Morphometric changes of sensorimotor structures in focal dystonia
Identifieur interne : 002D37 ( Main/Exploration ); précédent : 002D36; suivant : 002D38Morphometric changes of sensorimotor structures in focal dystonia
Auteurs : Mark Obermann [Allemagne] ; Ozguer Yaldizli [Allemagne] ; Armin De Greiff [Allemagne] ; Martin Lenard Lachenmayer [Allemagne] ; Anna Rebecca Buhl [Allemagne] ; Felicitus Tumczak [Allemagne] ; Elke Ruth Gizewski [Allemagne] ; Hans-Christoph Diener [Allemagne] ; Matthias Maschke [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Basal Ganglia (pathology), Basal Ganglia (physiopathology), Basal ganglion, Blepharospasm, Blepharospasm (drug therapy), Blepharospasm (epidemiology), Blepharospasm (physiopathology), Botulinum Toxins, Type A (therapeutic use), Caudate Nucleus (pathology), Caudate Nucleus (physiopathology), Dystonia, Dystonic Disorders (drug therapy), Dystonic Disorders (epidemiology), Dystonic Disorders (physiopathology), Female, Humans, Integration, Magnetic Resonance Imaging, Male, Middle Aged, Morphometry, Nervous system diseases, Neuromuscular Agents (therapeutic use), Psychomotor Disorders (drug therapy), Psychomotor Disorders (epidemiology), Severity of Illness Index, Torticollis, Torticollis (drug therapy), Torticollis (epidemiology), Torticollis (physiopathology), Voxel, basal ganglia., blepharospasm, cervical dystonia, focal dystonia, sensorimotor integration, torticollis, voxel‐based morphometry.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Blepharospasm, Dystonic Disorders, Psychomotor Disorders, Torticollis.
- epidemiology : Blepharospasm, Dystonic Disorders, Psychomotor Disorders, Torticollis.
- pathology : Basal Ganglia, Caudate Nucleus.
- physiopathology : Basal Ganglia, Blepharospasm, Caudate Nucleus, Dystonic Disorders, Torticollis.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index.
Abstract
Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel‐based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this stdy was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age‐ and gender‐matched controls. High‐resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21495
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001187
- to stream Istex, to step Curation: 001187
- to stream Istex, to step Checkpoint: 001845
- to stream PubMed, to step Corpus: 002765
- to stream PubMed, to step Curation: 002765
- to stream PubMed, to step Checkpoint: 002709
- to stream Ncbi, to step Merge: 001B74
- to stream Ncbi, to step Curation: 001B74
- to stream Ncbi, to step Checkpoint: 001B74
- to stream Main, to step Merge: 003C59
- to stream PascalFrancis, to step Corpus: 001644
- to stream PascalFrancis, to step Curation: 001677
- to stream PascalFrancis, to step Checkpoint: 001582
- to stream Main, to step Merge: 004172
- to stream Main, to step Curation: 002D37
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Morphometric changes of sensorimotor structures in focal dystonia</title>
<author><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name>
</author>
<author><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name>
</author>
<author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name>
</author>
<author><name sortKey="Lachenmayer, Martin Lenard" sort="Lachenmayer, Martin Lenard" uniqKey="Lachenmayer M" first="Martin Lenard" last="Lachenmayer">Martin Lenard Lachenmayer</name>
</author>
<author><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name>
</author>
<author><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name>
</author>
<author><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name>
</author>
<author><name sortKey="Diener, Hans Hristoph" sort="Diener, Hans Hristoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
</author>
<author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:09540BE5AD2D8AE73ABAB2C67E300EC9D590B8FF</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/mds.21495</idno>
<idno type="url">https://api.istex.fr/document/09540BE5AD2D8AE73ABAB2C67E300EC9D590B8FF/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001187</idno>
<idno type="wicri:Area/Istex/Curation">001187</idno>
<idno type="wicri:Area/Istex/Checkpoint">001845</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Obermann M:morphometric:changes:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:17443700</idno>
<idno type="wicri:Area/PubMed/Corpus">002765</idno>
<idno type="wicri:Area/PubMed/Curation">002765</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002709</idno>
<idno type="wicri:Area/Ncbi/Merge">001B74</idno>
<idno type="wicri:Area/Ncbi/Curation">001B74</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001B74</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Obermann M:morphometric:changes:of</idno>
<idno type="wicri:Area/Main/Merge">003C59</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:07-0349115</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001644</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001677</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001582</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Obermann M:morphometric:changes:of</idno>
<idno type="wicri:Area/Main/Merge">004172</idno>
<idno type="wicri:Area/Main/Curation">002D37</idno>
<idno type="wicri:Area/Main/Exploration">002D37</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Morphometric changes of sensorimotor structures in focal dystonia</title>
<author><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neuroradiology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lachenmayer, Martin Lenard" sort="Lachenmayer, Martin Lenard" uniqKey="Lachenmayer M" first="Martin Lenard" last="Lachenmayer">Martin Lenard Lachenmayer</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neuroradiology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diener, Hans Hristoph" sort="Diener, Hans Hristoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Duisburg—Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology and Neurophysiology, Bruederkrankenhaus Trier</wicri:regionArea>
<wicri:noRegion>Bruederkrankenhaus Trier</wicri:noRegion>
<wicri:noRegion>Bruederkrankenhaus Trier</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2007-06-15">2007-06-15</date>
<biblScope unit="vol">22</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1117">1117</biblScope>
<biblScope unit="page" to="1123">1123</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">09540BE5AD2D8AE73ABAB2C67E300EC9D590B8FF</idno>
<idno type="DOI">10.1002/mds.21495</idno>
<idno type="ArticleID">MDS21495</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Basal Ganglia (pathology)</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Basal ganglion</term>
<term>Blepharospasm</term>
<term>Blepharospasm (drug therapy)</term>
<term>Blepharospasm (epidemiology)</term>
<term>Blepharospasm (physiopathology)</term>
<term>Botulinum Toxins, Type A (therapeutic use)</term>
<term>Caudate Nucleus (pathology)</term>
<term>Caudate Nucleus (physiopathology)</term>
<term>Dystonia</term>
<term>Dystonic Disorders (drug therapy)</term>
<term>Dystonic Disorders (epidemiology)</term>
<term>Dystonic Disorders (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Integration</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
<term>Neuromuscular Agents (therapeutic use)</term>
<term>Psychomotor Disorders (drug therapy)</term>
<term>Psychomotor Disorders (epidemiology)</term>
<term>Severity of Illness Index</term>
<term>Torticollis</term>
<term>Torticollis (drug therapy)</term>
<term>Torticollis (epidemiology)</term>
<term>Torticollis (physiopathology)</term>
<term>Voxel</term>
<term>basal ganglia.</term>
<term>blepharospasm</term>
<term>cervical dystonia</term>
<term>focal dystonia</term>
<term>sensorimotor integration</term>
<term>torticollis</term>
<term>voxel‐based morphometry</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term>
<term>Neuromuscular Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Blepharospasm</term>
<term>Dystonic Disorders</term>
<term>Psychomotor Disorders</term>
<term>Torticollis</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Blepharospasm</term>
<term>Dystonic Disorders</term>
<term>Psychomotor Disorders</term>
<term>Torticollis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Caudate Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Blepharospasm</term>
<term>Caudate Nucleus</term>
<term>Dystonic Disorders</term>
<term>Torticollis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Blépharospasme</term>
<term>Dystonie</term>
<term>Intégration</term>
<term>Morphométrie</term>
<term>Noyau gris central</term>
<term>Système nerveux pathologie</term>
<term>Torticolis</term>
<term>Voxel</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Idiopathic cervical dystonia (CD) and benign essential blepharospasm (BEB) are the most common forms of focal dystonia. Previous autopsy and imaging studies suggested that these disorders are not accompanied by structural brain abnormalities. However, recent brain voxel‐based morphometry (VBM) studies of these conditions suggest that there actually may be changes in gray matter. The objective of this stdy was to detect possible gray matter abnormalities in patients with CD and BEB using VBM and to compare the results between the two conditions and with age‐ and gender‐matched controls. High‐resolution MRI was employed to evaluate healthy controls and individuals with BEB and CD. Eleven BEB, 9 CD, and 14 healthy control subjects were imaged. VBM revealed alterations of gray matter structures involved in sensorimotor processing in the individuals with focal dystonia. In CD subjects there was increased gray matter in the thalamus, caudate head bilaterally, superior temporal lobe, and left cerebellum, while gray matter was decreased in the putamen bilaterally. BEB subjects had increased gray matter in the caudate head and cerebellum bilaterally as well as decrease in the putamen and thalamus bilaterally. These findings strongly underline the recent notion that idiopathic focal dystonias might have a detectable structural correlate. They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Obermann, Mark" sort="Obermann, Mark" uniqKey="Obermann M" first="Mark" last="Obermann">Mark Obermann</name>
</noRegion>
<name sortKey="Buhl, Anna Rebecca" sort="Buhl, Anna Rebecca" uniqKey="Buhl A" first="Anna Rebecca" last="Buhl">Anna Rebecca Buhl</name>
<name sortKey="De Greiff, Armin" sort="De Greiff, Armin" uniqKey="De Greiff A" first="Armin" last="De Greiff">Armin De Greiff</name>
<name sortKey="Diener, Hans Hristoph" sort="Diener, Hans Hristoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name>
<name sortKey="Gizewski, Elke Ruth" sort="Gizewski, Elke Ruth" uniqKey="Gizewski E" first="Elke Ruth" last="Gizewski">Elke Ruth Gizewski</name>
<name sortKey="Lachenmayer, Martin Lenard" sort="Lachenmayer, Martin Lenard" uniqKey="Lachenmayer M" first="Martin Lenard" last="Lachenmayer">Martin Lenard Lachenmayer</name>
<name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name>
<name sortKey="Maschke, Matthias" sort="Maschke, Matthias" uniqKey="Maschke M" first="Matthias" last="Maschke">Matthias Maschke</name>
<name sortKey="Tumczak, Felicitus" sort="Tumczak, Felicitus" uniqKey="Tumczak F" first="Felicitus" last="Tumczak">Felicitus Tumczak</name>
<name sortKey="Yaldizli, Ozguer" sort="Yaldizli, Ozguer" uniqKey="Yaldizli O" first="Ozguer" last="Yaldizli">Ozguer Yaldizli</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D37 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D37 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:09540BE5AD2D8AE73ABAB2C67E300EC9D590B8FF |texte= Morphometric changes of sensorimotor structures in focal dystonia }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |