Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease
Identifieur interne : 002849 ( Main/Exploration ); précédent : 002848; suivant : 002850Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease
Auteurs : Young H. Sung [Corée du Sud] ; Sun J. Chung [Corée du Sud] ; Sung R. Kim [Corée du Sud] ; Myoung C. Lee [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Demography, Dopamine Agonists (therapeutic use), Extremities (physiopathology), Female, Humans, Hypokinesia (complications), Hypokinesia (diagnosis), Hypokinesia (physiopathology), Levodopa (therapeutic use), Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Posture, Prospective Studies, Questionnaires, Rest, Resting tremor, Severity of Illness Index, Treatment, Treatment Outcome, Tremor (drug therapy), Tremor (etiology), Tremor (physiopathology), bradykinesia, dopaminergic treatment, resting tremor, rigidity.
- MESH :
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- complications : Hypokinesia, Parkinson Disease.
- diagnosis : Hypokinesia, Parkinson Disease.
- drug therapy : Tremor.
- etiology : Tremor.
- physiopathology : Extremities, Hypokinesia, Parkinson Disease, Tremor.
- Aged, Demography, Female, Humans, Male, Middle Aged, Posture, Prospective Studies, Questionnaires, Rest, Severity of Illness Index, Treatment Outcome.
Abstract
We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21793
Affiliations:
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Kim</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01">2008-01</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="137">137</biblScope><biblScope unit="page" to="140">140</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC</idno><idno type="DOI">10.1002/mds.21793</idno><idno type="ArticleID">MDS21793</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Demography</term><term>Dopamine Agonists (therapeutic use)</term><term>Extremities (physiopathology)</term><term>Female</term><term>Humans</term><term>Hypokinesia (complications)</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (physiopathology)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Posture</term><term>Prospective Studies</term><term>Questionnaires</term><term>Rest</term><term>Resting tremor</term><term>Severity of Illness Index</term><term>Treatment</term><term>Treatment Outcome</term><term>Tremor (drug therapy)</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term><term>bradykinesia</term><term>dopaminergic treatment</term><term>resting tremor</term><term>rigidity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Extremities</term><term>Hypokinesia</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term><term>Prospective Studies</term><term>Questionnaires</term><term>Rest</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Traitement</term><term>Tremblement de repos</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Sung, Young H" sort="Sung, Young H" uniqKey="Sung Y" first="Young H." last="Sung">Young H. Sung</name></noRegion><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R." last="Kim">Sung R. Kim</name><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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