Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease
Identifieur interne : 001256 ( PascalFrancis/Checkpoint ); précédent : 001255; suivant : 001257Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease
Auteurs : Young H. Sung [Corée du Sud] ; Sun J. Chung [Corée du Sud] ; Sung R. Kim [Corée du Sud] ; Myoung C. Lee [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
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- Pascal (Inist)
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Abstract
We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.
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Chung</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R." last="Kim">Sung R. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0115912</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0115912 INIST</idno><idno type="RBID">Pascal:08-0115912</idno><idno type="wicri:Area/PascalFrancis/Corpus">001401</idno><idno type="wicri:Area/PascalFrancis/Curation">001918</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001256</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease</title><author><name sortKey="Sung, Young H" sort="Sung, Young H" uniqKey="Sung Y" first="Young H." last="Sung">Young H. Sung</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Gachon University College of Medicine</s1><s2>Incheon</s2><s3>KOR</s3><sZ>1 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R." last="Kim">Sung R. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Resting tremor</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tremblement de repos</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Traitement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>23</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease</s1></fA08><fA11 i1="01" i2="1"><s1>SUNG (Young H.)</s1></fA11><fA11 i1="02" i2="1"><s1>CHUNG (Sun J.)</s1></fA11><fA11 i1="03" i2="1"><s1>KIM (Sung R.)</s1></fA11><fA11 i1="04" i2="1"><s1>LEE (Myoung C.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Gachon University College of Medicine</s1><s2>Incheon</s2><s3>KOR</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>137-140</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000161904810240</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. 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Sung</name></noRegion><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R." last="Kim">Sung R. Kim</name><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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