Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease.
Identifieur interne : 001E96 ( Ncbi/Merge ); précédent : 001E95; suivant : 001E97Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease.
Auteurs : Young H. Sung [Corée du Sud] ; Sun J. Chung ; Sung R. Kim ; Myoung C. LeeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Demography, Dopamine Agonists (therapeutic use), Extremities (physiopathology), Female, Humans, Hypokinesia (complications), Hypokinesia (diagnosis), Hypokinesia (physiopathology), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Posture, Prospective Studies, Questionnaires, Rest, Severity of Illness Index, Treatment Outcome, Tremor (drug therapy), Tremor (etiology), Tremor (physiopathology).
- MESH :
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- complications : Hypokinesia, Parkinson Disease.
- diagnosis : Hypokinesia, Parkinson Disease.
- drug therapy : Tremor.
- etiology : Tremor.
- physiopathology : Extremities, Hypokinesia, Parkinson Disease, Tremor.
- Aged, Demography, Female, Humans, Male, Middle Aged, Posture, Prospective Studies, Questionnaires, Rest, Severity of Illness Index, Treatment Outcome.
Abstract
We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.
DOI: 10.1002/mds.21793
PubMed: 17987649
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease.</title><author><name sortKey="Sung, Young H" sort="Sung, Young H" uniqKey="Sung Y" first="Young H" last="Sung">Young H. Sung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Gachon University College of Medicine, Incheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Gachon University College of Medicine, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J" last="Chung">Sun J. Chung</name></author><author><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R" last="Kim">Sung R. Kim</name></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C" last="Lee">Myoung C. Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21793</idno><idno type="RBID">pubmed:17987649</idno><idno type="pmid">17987649</idno><idno type="wicri:Area/PubMed/Corpus">002463</idno><idno type="wicri:Area/PubMed/Curation">002463</idno><idno type="wicri:Area/PubMed/Checkpoint">002299</idno><idno type="wicri:Area/Ncbi/Merge">001E96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease.</title><author><name sortKey="Sung, Young H" sort="Sung, Young H" uniqKey="Sung Y" first="Young H" last="Sung">Young H. Sung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Gachon University College of Medicine, Incheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Gachon University College of Medicine, Incheon</wicri:regionArea><wicri:noRegion>Incheon</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J" last="Chung">Sun J. Chung</name></author><author><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R" last="Kim">Sung R. Kim</name></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C" last="Lee">Myoung C. Lee</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Demography</term><term>Dopamine Agonists (therapeutic use)</term><term>Extremities (physiopathology)</term><term>Female</term><term>Humans</term><term>Hypokinesia (complications)</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (physiopathology)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Posture</term><term>Prospective Studies</term><term>Questionnaires</term><term>Rest</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Tremor (drug therapy)</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Extremities</term><term>Hypokinesia</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term><term>Prospective Studies</term><term>Questionnaires</term><term>Rest</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17987649</PMID><DateCreated><Year>2008</Year><Month>01</Month><Day>31</Day></DateCreated><DateCompleted><Year>2008</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>1</Issue><PubDate><Year>2008</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>137-40</MedlinePgn></Pagination><Abstract><AbstractText>We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.</AbstractText><CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sung</LastName><ForeName>Young H</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Gachon University College of Medicine, Incheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Sun J</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sung R</ForeName><Initials>SR</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Myoung C</ForeName><Initials>MC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014202">Tremor</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>11</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>4</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>11</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21793</ArticleId><ArticleId IdType="pubmed">17987649</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country></list><tree><noCountry><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J" last="Chung">Sun J. Chung</name><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R" last="Kim">Sung R. Kim</name><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C" last="Lee">Myoung C. Lee</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Sung, Young H" sort="Sung, Young H" uniqKey="Sung Y" first="Young H" last="Sung">Young H. Sung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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