Movement Disorders (revue)

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Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease

Identifieur interne : 001401 ( PascalFrancis/Corpus ); précédent : 001400; suivant : 001402

Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease

Auteurs : Young H. Sung ; Sun J. Chung ; Sung R. Kim ; Myoung C. Lee

Source :

RBID : Pascal:08-0115912

Descripteurs français

English descriptors

Abstract

We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03   1    @0 Mov. disord.
A05       @2 23
A06       @2 1
A08 01  1  ENG  @1 Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease
A11 01  1    @1 SUNG (Young H.)
A11 02  1    @1 CHUNG (Sun J.)
A11 03  1    @1 KIM (Sung R.)
A11 04  1    @1 LEE (Myoung C.)
A14 01      @1 Department of Neurology, Gachon University College of Medicine @2 Incheon @3 KOR @Z 1 aut.
A14 02      @1 Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine @2 Seoul @3 KOR @Z 2 aut. @Z 3 aut. @Z 4 aut.
A20       @1 137-140
A21       @1 2008
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000161904810240
A44       @0 0000 @1 © 2008 INIST-CNRS. All rights reserved.
A45       @0 17 ref.
A47 01  1    @0 08-0115912
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Movement disorders
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C01 01    ENG  @0 We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.
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C03 01  X  ENG  @0 Resting tremor @5 01
C03 01  X  SPA  @0 Temblor reposo @5 01
C03 02  X  FRE  @0 Maladie de Parkinson @2 NM @5 02
C03 02  X  ENG  @0 Parkinson disease @2 NM @5 02
C03 02  X  SPA  @0 Parkinson enfermedad @2 NM @5 02
C03 03  X  FRE  @0 Pathologie du système nerveux @5 03
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C03 03  X  SPA  @0 Sistema nervioso patología @5 03
C03 04  X  FRE  @0 Traitement @5 09
C03 04  X  ENG  @0 Treatment @5 09
C03 04  X  SPA  @0 Tratamiento @5 09
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C07 01  X  ENG  @0 Extrapyramidal syndrome @5 37
C07 01  X  SPA  @0 Extrapiramidal síndrome @5 37
C07 02  X  FRE  @0 Mouvement involontaire @5 38
C07 02  X  ENG  @0 Involuntary movement @5 38
C07 02  X  SPA  @0 Movimiento involuntario @5 38
C07 03  X  FRE  @0 Trouble neurologique @5 40
C07 03  X  ENG  @0 Neurological disorder @5 40
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C07 04  X  SPA  @0 Encéfalo patología @5 41
C07 05  X  FRE  @0 Maladie dégénérative @5 42
C07 05  X  ENG  @0 Degenerative disease @5 42
C07 05  X  SPA  @0 Enfermedad degenerativa @5 42
C07 06  X  FRE  @0 Pathologie du système nerveux central @5 43
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C07 06  X  SPA  @0 Sistema nervosio central patología @5 43
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Format Inist (serveur)

NO : PASCAL 08-0115912 INIST
ET : Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease
AU : SUNG (Young H.); CHUNG (Sun J.); KIM (Sung R.); LEE (Myoung C.)
AF : Department of Neurology, Gachon University College of Medicine/Incheon/Corée, République de (1 aut.); Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine/Seoul/Corée, République de (2 aut., 3 aut., 4 aut.)
DT : Publication en série; Courte communication, note brève; Niveau analytique
SO : Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 1; Pp. 137-140; Bibl. 17 ref.
LA : Anglais
EA : We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.
CC : 002B17; 002B17G
FD : Tremblement de repos; Maladie de Parkinson; Pathologie du système nerveux; Traitement
FG : Syndrome extrapyramidal; Mouvement involontaire; Trouble neurologique; Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central
ED : Resting tremor; Parkinson disease; Nervous system diseases; Treatment
EG : Extrapyramidal syndrome; Involuntary movement; Neurological disorder; Cerebral disorder; Degenerative disease; Central nervous system disease
SD : Temblor reposo; Parkinson enfermedad; Sistema nervioso patología; Tratamiento
LO : INIST-20953.354000161904810240
ID : 08-0115912

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Pascal:08-0115912

Le document en format XML

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<ET>Factors Predicting Response to Dopaminergic Treatment for Resting Tremor of Parkinson's Disease</ET>
<AU>SUNG (Young H.); CHUNG (Sun J.); KIM (Sung R.); LEE (Myoung C.)</AU>
<AF>Department of Neurology, Gachon University College of Medicine/Incheon/Corée, République de (1 aut.); Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine/Seoul/Corée, République de (2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 1; Pp. 137-140; Bibl. 17 ref.</SO>
<LA>Anglais</LA>
<EA>We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.</EA>
<CC>002B17; 002B17G</CC>
<FD>Tremblement de repos; Maladie de Parkinson; Pathologie du système nerveux; Traitement</FD>
<FG>Syndrome extrapyramidal; Mouvement involontaire; Trouble neurologique; Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Resting tremor; Parkinson disease; Nervous system diseases; Treatment</ED>
<EG>Extrapyramidal syndrome; Involuntary movement; Neurological disorder; Cerebral disorder; Degenerative disease; Central nervous system disease</EG>
<SD>Temblor reposo; Parkinson enfermedad; Sistema nervioso patología; Tratamiento</SD>
<LO>INIST-20953.354000161904810240</LO>
<ID>08-0115912</ID>
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