MovDisordV3, Main, Merge, bibRecord, 003427

Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease

Identifieur interne : 003427 ( Main/Merge ); précédent : 003426; suivant : 003428

Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease

Auteurs : Young H. Sung [Corée du Sud] ; Sun J. Chung [Corée du Sud] ; Sung R. Kim [Corée du Sud] ; Myoung C. Lee [Corée du Sud]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-01.

RBID : ISTEX:89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC

English descriptors

KwdEn :
- Aged, Demography, Dopamine Agonists (therapeutic use), Extremities (physiopathology), Female, Humans, Hypokinesia (complications), Hypokinesia (diagnosis), Hypokinesia (physiopathology), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson's disease, Posture, Prospective Studies, Questionnaires, Rest, Severity of Illness Index, Treatment Outcome, Tremor (drug therapy), Tremor (etiology), Tremor (physiopathology), bradykinesia, dopaminergic treatment, resting tremor, rigidity.
MESH :
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- complications : Hypokinesia, Parkinson Disease.
- diagnosis : Hypokinesia, Parkinson Disease.
- drug therapy : Tremor.
- etiology : Tremor.
- physiopathology : Extremities, Hypokinesia, Parkinson Disease, Tremor.
- Aged, Demography, Female, Humans, Male, Middle Aged, Posture, Prospective Studies, Questionnaires, Rest, Severity of Illness Index, Treatment Outcome.

Abstract

We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC/fulltext/pdf

DOI: 10.1002/mds.21793

Links to Exploration step

ISTEX:89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC

Le document en format XML

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<front><div type="abstract" xml:lang="en">We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty-five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features.</div>
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   |clé=     ISTEX:89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC
   |texte=   Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease
}}

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Movement Disorders (revue)

Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease

Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease

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	Movement Disorders (revue)
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