Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease
Identifieur interne : 002A70 ( Istex/Corpus ); précédent : 002A69; suivant : 002A71Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease
Auteurs : Young H. Sung ; Sun J. Chung ; Sung R. Kim ; Myoung C. LeeSource :
- Movement Disorders [ 0885-3185 ] ; 2008-01.
English descriptors
Abstract
We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21793
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Sung</name><affiliation><mods:affiliation>Department of Neurology, Gachon University College of Medicine, Incheon, Korea</mods:affiliation></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><affiliation><mods:affiliation>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Sung R" sort="Kim, Sung R" uniqKey="Kim S" first="Sung R." last="Kim">Sung R. Kim</name><affiliation><mods:affiliation>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. 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Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Young H. Sung MD</name><affiliations><json:string>Department of Neurology, Gachon University College of Medicine, Incheon, Korea</json:string></affiliations></json:item><json:item><name>Sun J. Chung MD</name><affiliations><json:string>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Sung R. Kim RN</name><affiliations><json:string>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Myoung C. Lee MD</name><affiliations><json:string>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopaminergic treatment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>resting tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bradykinesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rigidity</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01"></date><biblScope unit="vol">23</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="137">137</biblScope><biblScope unit="page" to="140">140</biblScope></imprint></monogr><idno type="istex">89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC</idno><idno type="DOI">10.1002/mds.21793</idno><idno type="ArticleID">MDS21793</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>dopaminergic treatment</term></item><item><term>resting tremor</term></item><item><term>bradykinesia</term></item><item><term>rigidity</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-06-25">Received</change><change when="2007-09-30">Registration</change><change when="2008-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/89E13EB2499D9B29C65DD0B91B5BAAB929BE82CC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (<i>P</i> = 0.015) and Hoehn and Yahr stage (<i>P</i> = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (<i>P</i> = 0.012), bradykinesia (<i>P</i> = 0.021) and postural impairment (<i>P</i> = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Response to Dopaminergic Treatment for PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Factors predicting response to dopaminergic treatment for resting tremor of Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Young H.</namePart><namePart type="family">Sung</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Gachon University College of Medicine, Incheon, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sun J.</namePart><namePart type="family">Chung</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><description>Correspondence: Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 388–1, Poongnap‐dong, Songpa‐gu, Seoul, 138–736, South Korea</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sung R.</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Myoung C.</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center for Parkinsonism and Other Movement Disorders, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-01</dateIssued><dateCaptured encoding="w3cdtf">2007-06-25</dateCaptured><dateValid encoding="w3cdtf">2007-09-30</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">17</extent><extent unit="words">2427</extent></physicalDescription><abstract lang="en">We aimed to evaluate the clinical factors predicting response to dopaminergic treatment for resting tremor in patients with Parkinson's disease (PD). Eighty‐five PD patients with prominent resting tremor, defined as tremors of score greater than 3 in at least one limb on the Unified Parkinson's Disease Rating Scale (UPDRS), were divided into those responsive or nonresponsive to dopaminergic treatment. Responsiveness was defined as a reduction of at least two points for more than 3 months in the UPDRS tremor score. Of the 85 patients, 36 (42.4%) were responsive and 49 (57.6%) were nonresponsive to dopaminergic treatment. Initial UPDRS III score (P = 0.015) and Hoehn and Yahr stage (P = 0.010) were each significantly higher in the RG than in the NRG. UPDRS subscores for rigidity (P = 0.012), bradykinesia (P = 0.021) and postural impairment (P = 0.018) also correlated with responsiveness to dopaminergic treatment. Resting tremor in PD patients was more responsive to dopaminergic treatment when accompanied by moderate degrees of bradykinesia and rigidity than in patients without other prominent parkinsonian features. © 2007 Movement Disorder Society</abstract><note type="funding">Asan Institute for Life Sciences, Seoul, Korea - No. 2006–416; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dopaminergic treatment</topic><topic>resting tremor</topic><topic>bradykinesia</topic><topic>rigidity</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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