Impact of Huntington's disease on quality of life
Identifieur interne : 004779 ( Main/Exploration ); précédent : 004778; suivant : 004780Impact of Huntington's disease on quality of life
Auteurs : D. I. Helder [Pays-Bas] ; A. A. Kaptein [Pays-Bas] ; G. M. J. Van Kempen [Pays-Bas] ; J. C. Van Houwelingen [Pays-Bas] ; R. A. C. Roos [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adaptation, Psychological, Adult, Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Female, Humans, Huntington Disease (diagnosis), Huntington Disease (psychology), Huntington disease, Huntington's disease, Male, Middle Aged, Neuropsychological Tests, Psychological effect, Psychological well being, Psychometrics, Quality of Life, Quality of life, Self Concept, Sickness Impact Profile, Sickness Impact Profile Gilson, Social Adjustment, quality of life.
- MESH :
- diagnosis : Cognition Disorders, Huntington Disease.
- epidemiology : Cognition Disorders.
- psychology : Huntington Disease.
- Adaptation, Psychological, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Self Concept, Sickness Impact Profile, Social Adjustment.
Abstract
The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health‐related quality of life (QOL). Seventy‐seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini‐Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well‐being, the latter being more severely affected. Implications for further research and clinical practice are discussed. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1056
Affiliations:
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Le document en format XML
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I." last="Helder">D. I. Helder</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre (LUMC)</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre (LUMC)</wicri:noRegion></affiliation></author><author><name sortKey="Kaptein, A A" sort="Kaptein, A A" uniqKey="Kaptein A" first="A. A." last="Kaptein">A. A. Kaptein</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre (LUMC)</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre (LUMC)</wicri:noRegion></affiliation></author><author><name sortKey="Van Kempen, G M J" sort="Van Kempen, G M J" uniqKey="Van Kempen G" first="G. M. J." last="Van Kempen">G. M. J. Van Kempen</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre (LUMC)</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre (LUMC)</wicri:noRegion></affiliation></author><author><name sortKey="Van Houwelingen, J C" sort="Van Houwelingen, J C" uniqKey="Van Houwelingen J" first="J. C." last="Van Houwelingen">J. C. Van Houwelingen</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Medical Statistics, Leiden University Medical Centre (LUMC)</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre (LUMC)</wicri:noRegion></affiliation></author><author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre (LUMC)</wicri:regionArea><wicri:noRegion>Leiden University Medical Centre (LUMC)</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-03">2001-03</date><biblScope unit="vol">16</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="325">325</biblScope><biblScope unit="page" to="330">330</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6A9288D5D535336BF046F862803853AC246D438C</idno><idno type="DOI">10.1002/mds.1056</idno><idno type="ArticleID">MDS1056</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Psychological</term><term>Adult</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (psychology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychological effect</term><term>Psychological well being</term><term>Psychometrics</term><term>Quality of Life</term><term>Quality of life</term><term>Self Concept</term><term>Sickness Impact Profile</term><term>Sickness Impact Profile Gilson</term><term>Social Adjustment</term><term>quality of life</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Quality of Life</term><term>Self Concept</term><term>Sickness Impact Profile</term><term>Social Adjustment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Bien être psychologique</term><term>Chorée Huntington</term><term>Effet psychologique</term><term>Psychométrie</term><term>Qualité vie</term><term>Sickness Impact Profile Gilson</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health‐related quality of life (QOL). Seventy‐seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini‐Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well‐being, the latter being more severely affected. Implications for further research and clinical practice are discussed. © 2001 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Helder, D I" sort="Helder, D I" uniqKey="Helder D" first="D. I." last="Helder">D. I. Helder</name></noRegion><name sortKey="Kaptein, A A" sort="Kaptein, A A" uniqKey="Kaptein A" first="A. A." last="Kaptein">A. A. Kaptein</name><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><name sortKey="Van Houwelingen, J C" sort="Van Houwelingen, J C" uniqKey="Van Houwelingen J" first="J. C." last="Van Houwelingen">J. C. Van Houwelingen</name><name sortKey="Van Kempen, G M J" sort="Van Kempen, G M J" uniqKey="Van Kempen G" first="G. M. J." last="Van Kempen">G. M. J. Van Kempen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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