MovDisordV3, PubMed, Corpus, bibRecord, 003D72

Impact of Huntington's disease on quality of life.

Identifieur interne : 003D72 ( PubMed/Corpus ); précédent : 003D71; suivant : 003D73

Impact of Huntington's disease on quality of life.

Auteurs : D I Helder ; A A Kaptein ; G M Van Kempen ; J C Van Houwelingen ; R A Roos

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.

RBID : pubmed:11295789

English descriptors

KwdEn :
- Adaptation, Psychological, Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Female, Humans, Huntington Disease (diagnosis), Huntington Disease (psychology), Male, Middle Aged, Neuropsychological Tests, Quality of Life, Self Concept, Sickness Impact Profile, Social Adjustment.
MESH :
- diagnosis : Cognition Disorders, Huntington Disease.
- epidemiology : Cognition Disorders.
- psychology : Huntington Disease.
- Adaptation, Psychological, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Self Concept, Sickness Impact Profile, Social Adjustment.

Abstract

The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.

PubMed: 11295789

Links to Exploration step

pubmed:11295789

Le document en format XML

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<author><name sortKey="Helder, D I" sort="Helder, D I" uniqKey="Helder D" first="D I" last="Helder">D I Helder</name>
<affiliation><nlm:affiliation>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre, the Netherlands. dhelder@hotmail.com</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kaptein, A A" sort="Kaptein, A A" uniqKey="Kaptein A" first="A A" last="Kaptein">A A Kaptein</name>
</author>
<author><name sortKey="Van Kempen, G M" sort="Van Kempen, G M" uniqKey="Van Kempen G" first="G M" last="Van Kempen">G M Van Kempen</name>
</author>
<author><name sortKey="Van Houwelingen, J C" sort="Van Houwelingen, J C" uniqKey="Van Houwelingen J" first="J C" last="Van Houwelingen">J C Van Houwelingen</name>
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<author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name>
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<affiliation><nlm:affiliation>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre, the Netherlands. dhelder@hotmail.com</nlm:affiliation>
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<author><name sortKey="Kaptein, A A" sort="Kaptein, A A" uniqKey="Kaptein A" first="A A" last="Kaptein">A A Kaptein</name>
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<author><name sortKey="Van Kempen, G M" sort="Van Kempen, G M" uniqKey="Van Kempen G" first="G M" last="Van Kempen">G M Van Kempen</name>
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<author><name sortKey="Van Houwelingen, J C" sort="Van Houwelingen, J C" uniqKey="Van Houwelingen J" first="J C" last="Van Houwelingen">J C Van Houwelingen</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (diagnosis)</term>
<term>Huntington Disease (psychology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Quality of Life</term>
<term>Self Concept</term>
<term>Sickness Impact Profile</term>
<term>Social Adjustment</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
<term>Huntington Disease</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Quality of Life</term>
<term>Self Concept</term>
<term>Sickness Impact Profile</term>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11295789</PMID>
<DateCreated><Year>2001</Year>
<Month>04</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2001</Year>
<Month>08</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2004</Year>
<Month>11</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>16</Volume>
<Issue>2</Issue>
<PubDate><Year>2001</Year>
<Month>Mar</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Impact of Huntington's disease on quality of life.</ArticleTitle>
<Pagination><MedlinePgn>325-30</MedlinePgn>
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<Abstract><AbstractText>The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.</AbstractText>
<CopyrightInformation>Copyright 2001 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Helder</LastName>
<ForeName>D I</ForeName>
<Initials>DI</Initials>
<AffiliationInfo><Affiliation>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre, the Netherlands. dhelder@hotmail.com</Affiliation>
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<Author ValidYN="Y"><LastName>Kaptein</LastName>
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<Author ValidYN="Y"><LastName>van Kempen</LastName>
<ForeName>G M</ForeName>
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<Author ValidYN="Y"><LastName>van Houwelingen</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
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<Author ValidYN="Y"><LastName>Roos</LastName>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000223">Adaptation, Psychological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D003072">Cognition Disorders</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006816">Huntington Disease</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011788">Quality of Life</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012649">Self Concept</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D018434">Sickness Impact Profile</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012917">Social Adjustment</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year>
<Month>4</Month>
<Day>11</Day>
<Hour>10</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2001</Year>
<Month>8</Month>
<Day>31</Day>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Impact of Huntington's disease on quality of life.

Impact of Huntington's disease on quality of life.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki