MovDisordV3, PascalFrancis, Corpus, bibRecord, 002A12

Impact of Huntington's Disease on quality of life

Identifieur interne : 002A12 ( PascalFrancis/Corpus ); précédent : 002A11; suivant : 002A13

Impact of Huntington's Disease on quality of life

Auteurs : D. I. Helder ; A. A. Kaptein ; G. M. J. Van Kempen ; J. C. Van Houwelingen ; R. A. C. Roos

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:01-0335232

Descripteurs français

Pascal (Inist)
- Chorée Huntington, Qualité vie, Sickness Impact Profile Gilson, Bien être psychologique, Effet psychologique, Psychométrie, Adulte.

English descriptors

KwdEn :
- Adult, Huntington disease, Psychological effect, Psychological well being, Psychometrics, Quality of life, Sickness Impact Profile Gilson.

Abstract

The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP), Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, hut not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 HELDER (D. I.)`
A11	`02`	`1`		`@1 KAPTEIN (A. A.)`
A11	`03`	`1`		`@1 VAN KEMPEN (G. M. J.)`
A11	`04`	`1`		`@1 VAN HOUWELINGEN (J. C.)`
A11	`05`	`1`		`@1 ROOS (R. A. C.)`
A14	`01`			`@1 Medical Psychology, Department of Psychiatry, Leiden University Medical Centre (LUMC) @3 NLD @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A14	`02`			`@1 Department of Medical Statistics, Leiden University Medical Centre (LUMC) @3 NLD @Z 4 aut.`
A14	`03`			`@1 Department of Neurology, Leiden University Medical Centre (LUMC) @3 NLD @Z 5 aut.`
A20				`@1 325-330`
A21				`@1 2001`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2001 INIST-CNRS. All rights reserved.`
A45				`@0 24 ref.`
A47	`01`	`1`		`@0 01-0335232`
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A61				`@0 A`
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C01	`01`		`ENG`	@0 The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP), Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, hut not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.
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C07	`02`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`03`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`03`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`03`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`04`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
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C07	`04`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
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C07	`07`	`X`	`FRE`	`@0 Maladie héréditaire @5 42`
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C07	`07`	`X`	`SPA`	`@0 Enfermedad hereditaria @5 42`
N21				`@1 232`

Format Inist (serveur)

NO :	PASCAL 01-0335232 INIST
ET :	Impact of Huntington's Disease on quality of life
AU :	HELDER (D. I.); KAPTEIN (A. A.); VAN KEMPEN (G. M. J.); VAN HOUWELINGEN (J. C.); ROOS (R. A. C.)
AF :	Medical Psychology, Department of Psychiatry, Leiden University Medical Centre (LUMC)/Pays-Bas (1 aut., 2 aut., 3 aut.); Department of Medical Statistics, Leiden University Medical Centre (LUMC)/Pays-Bas (4 aut.); Department of Neurology, Leiden University Medical Centre (LUMC)/Pays-Bas (5 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 2; Pp. 325-330; Bibl. 24 ref.
LA :	Anglais
EA :	The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP), Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, hut not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.
CC :	002B17G
FD :	Chorée Huntington; Qualité vie; Sickness Impact Profile Gilson; Bien être psychologique; Effet psychologique; Psychométrie; Adulte
FG :	Homme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire
ED :	Huntington disease; Quality of life; Sickness Impact Profile Gilson; Psychological well being; Psychological effect; Psychometrics; Adult
EG :	Human; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease
SD :	Corea Huntington; Calidad vida; Sickness Impact Profile Gilson; Bienestar psicológico; Efecto psicológico; Psicometría; Adulto
LO :	INIST-20953.354000096545190230
ID :	01-0335232

Links to Exploration step

Pascal:01-0335232

Le document en format XML

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<front><div type="abstract" xml:lang="en">The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP), Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, hut not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.</div>
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<s5>39</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
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<s5>40</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
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<fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
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<fC07 i1="07" i2="X" l="FRE"><s0>Maladie héréditaire</s0>
<s5>42</s5>
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<fC07 i1="07" i2="X" l="ENG"><s0>Genetic disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0>
<s5>42</s5>
</fC07>
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<server><NO>PASCAL 01-0335232 INIST</NO>
<ET>Impact of Huntington's Disease on quality of life</ET>
<AU>HELDER (D. I.); KAPTEIN (A. A.); VAN KEMPEN (G. M. J.); VAN HOUWELINGEN (J. C.); ROOS (R. A. C.)</AU>
<AF>Medical Psychology, Department of Psychiatry, Leiden University Medical Centre (LUMC)/Pays-Bas (1 aut., 2 aut., 3 aut.); Department of Medical Statistics, Leiden University Medical Centre (LUMC)/Pays-Bas (4 aut.); Department of Neurology, Leiden University Medical Centre (LUMC)/Pays-Bas (5 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 2; Pp. 325-330; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP), Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, hut not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.</EA>
<CC>002B17G</CC>
<FD>Chorée Huntington; Qualité vie; Sickness Impact Profile Gilson; Bien être psychologique; Effet psychologique; Psychométrie; Adulte</FD>
<FG>Homme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire</FG>
<ED>Huntington disease; Quality of life; Sickness Impact Profile Gilson; Psychological well being; Psychological effect; Psychometrics; Adult</ED>
<EG>Human; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease</EG>
<SD>Corea Huntington; Calidad vida; Sickness Impact Profile Gilson; Bienestar psicológico; Efecto psicológico; Psicometría; Adulto</SD>
<LO>INIST-20953.354000096545190230</LO>
<ID>01-0335232</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Impact of Huntington's Disease on quality of life

Impact of Huntington's Disease on quality of life

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