Idazoxan, an alpha‐2 antagonist, and L‐DOPA‐induced dyskinesias in patients with Parkinson's disease
Identifieur interne : 004780 ( Main/Exploration ); précédent : 004779; suivant : 004781Idazoxan, an alpha‐2 antagonist, and L‐DOPA‐induced dyskinesias in patients with Parkinson's disease
Auteurs : Olivier Rascol [France] ; I. Arnulf [France] ; H. Peyro-Saint Paul [France] ; C. Brefel-Courbon [France] ; M. Vidailhet [France] ; C. Thalamas [France] ; A. M. Bonnet [France] ; S. Descombes [France] ; B. Bejjani [France] ; N. Fabre [France] ; J. L. Montastruc [France] ; Yves Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Administration, Oral, Adrenergic alpha-Antagonists (adverse effects), Adrenergic alpha-Antagonists (therapeutic use), Aged, Antagonist, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Chemotherapy, Dose-Response Relationship, Drug, Dyskinesia, Dyskinesia, Drug-Induced (drug therapy), Female, Human, Humans, Idazoxan, Idazoxan (adverse effects), Idazoxan (therapeutic use), Levodopa (adverse effects), Levodopa (therapeutic use), L‐DOPA, dyskinesia, Male, Middle Aged, Neurologic Examination (drug effects), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Phase II trial, Pilot Projects, Treatment, idazoxan, α2 receptors, α2-Adrenergic receptor.
- MESH :
- chemical , adverse effects : Adrenergic alpha-Antagonists, Antiparkinson Agents, Idazoxan, Levodopa.
- chemical , therapeutic use : Adrenergic alpha-Antagonists, Antiparkinson Agents, Idazoxan, Levodopa.
- drug effects : Neurologic Examination.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- Administration, Oral, Aged, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Pilot Projects.
Abstract
Dyskinesia is a frequent and disabling side effect in patients with Parkinson's disease treated with chronic dopatherapy. Preclinical data in the 1‐methyl‐4‐phenyl‐1,2,3,6,‐tetrahydropyridine (MPTP) monkey suggest that alpha‐2 antagonists may reduce dihydroxyphenylalanine (L‐DOPA)‐induced dyskinesia. We assessed, in a pilot randomised placebo‐controlled study, the effects of single oral doses (10 mg, 20 mg, and 40 mg) of idazoxan, an alpha‐2 antagonist, on motor parkinsonian disability and L‐DOPA‐induced dyskinesia following an acute oral challenge of L‐DOPA in 18 patients with Parkinson's disease. The severity of L‐DOPA‐induced dyskinesia improved after 20 mg idazoxan pretreatment, while there was no concommittant deterioration in the antiparkinsonian response to L‐DOPA. These results suggest that blocking alpha‐2 receptors in patients with Parkinson's disease might improve L‐DOPA‐induced dyskinesia without the cost of a return of parkinsonian symptomatology. Further studies are required to assess whether this property could have potential therapeutic applications in the long‐term management of dyskinetic patients with Parkinson's disease. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1143
Affiliations:
- France
- Midi-Pyrénées, Île-de-France
- Paris, Toulouse
- Hôpital de la Salpêtrière, Université Toulouse III - Paul Sabatier, Université de Toulouse
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Le document en format XML
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<term>Aged</term>
<term>Antagonist</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
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<term>Dose-Response Relationship, Drug</term>
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<term>Female</term>
<term>Human</term>
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<term>Idazoxan</term>
<term>Idazoxan (adverse effects)</term>
<term>Idazoxan (therapeutic use)</term>
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<front><div type="abstract" xml:lang="en">Dyskinesia is a frequent and disabling side effect in patients with Parkinson's disease treated with chronic dopatherapy. Preclinical data in the 1‐methyl‐4‐phenyl‐1,2,3,6,‐tetrahydropyridine (MPTP) monkey suggest that alpha‐2 antagonists may reduce dihydroxyphenylalanine (L‐DOPA)‐induced dyskinesia. We assessed, in a pilot randomised placebo‐controlled study, the effects of single oral doses (10 mg, 20 mg, and 40 mg) of idazoxan, an alpha‐2 antagonist, on motor parkinsonian disability and L‐DOPA‐induced dyskinesia following an acute oral challenge of L‐DOPA in 18 patients with Parkinson's disease. The severity of L‐DOPA‐induced dyskinesia improved after 20 mg idazoxan pretreatment, while there was no concommittant deterioration in the antiparkinsonian response to L‐DOPA. These results suggest that blocking alpha‐2 receptors in patients with Parkinson's disease might improve L‐DOPA‐induced dyskinesia without the cost of a return of parkinsonian symptomatology. Further studies are required to assess whether this property could have potential therapeutic applications in the long‐term management of dyskinetic patients with Parkinson's disease. © 2001 Movement Disorder Society.</div>
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