MovDisordV3, Main, Curation, bibRecord, 004779

Impact of Huntington's disease on quality of life

Identifieur interne : 004779 ( Main/Curation ); précédent : 004778; suivant : 004780

Impact of Huntington's disease on quality of life

Auteurs : D. I. Helder [Pays-Bas] ; A. A. Kaptein [Pays-Bas] ; G. M. J. Van Kempen [Pays-Bas] ; J. C. Van Houwelingen [Pays-Bas] ; R. A. C. Roos [Pays-Bas]

Source :

Movement Disorders [ 0885-3185 ] ; 2001-03.

RBID : ISTEX:6A9288D5D535336BF046F862803853AC246D438C

Descripteurs français

Pascal (Inist)
- Adulte, Bien être psychologique, Chorée Huntington, Effet psychologique, Psychométrie, Qualité vie, Sickness Impact Profile Gilson.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adaptation, Psychological, Adult, Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Female, Humans, Huntington Disease (diagnosis), Huntington Disease (psychology), Huntington disease, Huntington's disease, Male, Middle Aged, Neuropsychological Tests, Psychological effect, Psychological well being, Psychometrics, Quality of Life, Quality of life, Self Concept, Sickness Impact Profile, Sickness Impact Profile Gilson, Social Adjustment, quality of life.
MESH :
- diagnosis : Cognition Disorders, Huntington Disease.
- epidemiology : Cognition Disorders.
- psychology : Huntington Disease.
- Adaptation, Psychological, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Self Concept, Sickness Impact Profile, Social Adjustment.

Abstract

The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health‐related quality of life (QOL). Seventy‐seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini‐Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well‐being, the latter being more severely affected. Implications for further research and clinical practice are discussed. © 2001 Movement Disorder Society.

Url:

https://api.istex.fr/document/6A9288D5D535336BF046F862803853AC246D438C/fulltext/pdf

DOI: 10.1002/mds.1056

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP), Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, hut not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.</div>
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<author><name sortKey="Van Kempen, G M J" sort="Van Kempen, G M J" uniqKey="Van Kempen G" first="G. M. J." last="Van Kempen">G. M. J. Van Kempen</name>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health‐related quality of life (QOL). Seventy‐seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini‐Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well‐being, the latter being more severely affected. Implications for further research and clinical practice are discussed. © 2001 Movement Disorder Society.</div>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to systematically assess the impact of Huntington's disease (HD) on patients' health-related quality of life (QOL). Seventy-seven patients with a clinically confirmed diagnosis of HD were interviewed by means of the Sickness Impact Profile (SIP). Additional data were gathered on patients' motor performance by means of the motor section of the Unified Huntington Disease Rating Scale (UHDRS), and cognitive performance by means of the Mini-Mental State (MMS). Patients had high scores on the SIP subscales, indicating moderate to severe functional impairment. Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension. We conclude that HD has a great impact on patients' physical and psychosocial well-being, the latter being more severely affected. Implications for further research and clinical practice are discussed.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Impact of Huntington's disease on quality of life

Impact of Huntington's disease on quality of life

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