MovDisordV3, Main, Exploration, bibRecord, 002D30

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Identifieur interne : 002D30 ( Main/Exploration ); précédent : 002D29; suivant : 002D31

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Auteurs : Jörg Spiegel [Allemagne] ; Dirk Hellwig [Allemagne] ; Georgios Farmakis [Allemagne] ; Wolfgang H. Jost [Allemagne] ; Samuel Samnick [Allemagne] ; Klaus Fassbender [Allemagne] ; Carl-Martin Kirsch [Allemagne] ; Ulrich Dillmann [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-05-15.

RBID : ISTEX:58E10EF39E72D8F10CC9E470A07A7585DA7199CD

Descripteurs français

Pascal (Inist)
- Dégénérescence, Parkinson maladie, Phénotype, Scintigraphie, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Aged, Analysis of Variance, Autonomic Nervous System Diseases (complications), Autonomic Nervous System Diseases (pathology), Autonomic Nervous System Diseases (radionuclide imaging), Blood Pressure, Degeneration, Female, Humans, Iodine Radioisotopes (diagnostic use), Iodine Radioisotopes (pharmacokinetics), MIBG scintigraphy, Male, Middle Aged, Myocardium (pathology), Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Phenotype, Radionuclide Imaging (methods), Scintigraphy, Severity of Illness Index, myocardial sympathetic degeneration.
MESH :
- chemical , diagnostic use : Iodine Radioisotopes.
- complications : Autonomic Nervous System Diseases, Parkinson Disease.
- methods : Radionuclide Imaging.
- pathology : Autonomic Nervous System Diseases, Myocardium, Parkinson Disease.
- chemical , pharmacokinetics : Iodine Radioisotopes.
- radionuclide imaging : Autonomic Nervous System Diseases, Parkinson Disease.
- Adult, Aged, Analysis of Variance, Blood Pressure, Female, Humans, Male, Middle Aged, Phenotype, Severity of Illness Index.

Abstract

In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor‐dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart‐to‐mediastinum (H/M) count‐ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic‐rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/58E10EF39E72D8F10CC9E470A07A7585DA7199CD/fulltext/pdf

DOI: 10.1002/mds.21499

Affiliations:

Allemagne

Le document en format XML

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<author><name sortKey="Farmakis, Georgios" sort="Farmakis, Georgios" uniqKey="Farmakis G" first="Georgios" last="Farmakis">Georgios Farmakis</name>
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<term>Autonomic Nervous System Diseases (pathology)</term>
<term>Autonomic Nervous System Diseases (radionuclide imaging)</term>
<term>Blood Pressure</term>
<term>Degeneration</term>
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<term>Humans</term>
<term>Iodine Radioisotopes (diagnostic use)</term>
<term>Iodine Radioisotopes (pharmacokinetics)</term>
<term>MIBG scintigraphy</term>
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<term>Middle Aged</term>
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<term>Nervous system diseases</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
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<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor‐dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart‐to‐mediastinum (H/M) count‐ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic‐rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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