Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease
Identifieur interne : 001838 ( Istex/Checkpoint ); précédent : 001837; suivant : 001839Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease
Auteurs : Jörg Spiegel [Allemagne] ; Dirk Hellwig [Allemagne] ; Georgios Farmakis [Allemagne] ; Wolfgang H. Jost [Allemagne] ; Samuel Samnick [Allemagne] ; Klaus Fassbender [Allemagne] ; Carl-Martin Kirsch [Allemagne] ; Ulrich Dillmann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-05-15.
English descriptors
Abstract
In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor‐dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart‐to‐mediastinum (H/M) count‐ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic‐rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21499
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-05-15">2007-05-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1004">1004</biblScope><biblScope unit="page" to="1008">1008</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">58E10EF39E72D8F10CC9E470A07A7585DA7199CD</idno><idno type="DOI">10.1002/mds.21499</idno><idno type="ArticleID">MDS21499</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MIBG scintigraphy</term><term>Parkinson's disease</term><term>myocardial sympathetic degeneration</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor‐dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart‐to‐mediastinum (H/M) count‐ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic‐rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name></noRegion><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><name sortKey="Farmakis, Georgios" sort="Farmakis, Georgios" uniqKey="Farmakis G" first="Georgios" last="Farmakis">Georgios Farmakis</name><name sortKey="Fassbender, Klaus" sort="Fassbender, Klaus" uniqKey="Fassbender K" first="Klaus" last="Fassbender">Klaus Fassbender</name><name sortKey="Hellwig, Dirk" sort="Hellwig, Dirk" uniqKey="Hellwig D" first="Dirk" last="Hellwig">Dirk Hellwig</name><name sortKey="Jost, Wolfgang H" sort="Jost, Wolfgang H" uniqKey="Jost W" first="Wolfgang H." last="Jost">Wolfgang H. Jost</name><name sortKey="Kirsch, Carl Artin" sort="Kirsch, Carl Artin" uniqKey="Kirsch C" first="Carl-Martin" last="Kirsch">Carl-Martin Kirsch</name><name sortKey="Samnick, Samuel" sort="Samnick, Samuel" uniqKey="Samnick S" first="Samuel" last="Samnick">Samuel Samnick</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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