Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease.
Identifieur interne : 002771 ( PubMed/Corpus ); précédent : 002770; suivant : 002772Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease.
Auteurs : Jörg Spiegel ; Dirk Hellwig ; Georgios Farmakis ; Wolfgang H. Jost ; Samuel Samnick ; Klaus Fassbender ; Carl-Martin Kirsch ; Ulrich DillmannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Autonomic Nervous System Diseases (complications), Autonomic Nervous System Diseases (pathology), Autonomic Nervous System Diseases (radionuclide imaging), Blood Pressure, Female, Humans, Iodine Radioisotopes (diagnostic use), Iodine Radioisotopes (pharmacokinetics), Male, Middle Aged, Myocardium (pathology), Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Phenotype, Radionuclide Imaging (methods), Severity of Illness Index.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes.
- complications : Autonomic Nervous System Diseases, Parkinson Disease.
- methods : Radionuclide Imaging.
- pathology : Autonomic Nervous System Diseases, Myocardium, Parkinson Disease.
- chemical , pharmacokinetics : Iodine Radioisotopes.
- radionuclide imaging : Autonomic Nervous System Diseases, Parkinson Disease.
- Adult, Aged, Analysis of Variance, Blood Pressure, Female, Humans, Male, Middle Aged, Phenotype, Severity of Illness Index.
Abstract
In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor-dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart-to-mediastinum (H/M) count-ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic-rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor.
DOI: 10.1002/mds.21499
PubMed: 17427942
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pubmed:17427942Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease.</title><author><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name><affiliation><nlm:affiliation>Department of Neurology, Saarland University, D-66421 Homburg/Saar, Germany. nejspi@uniklinik-saarland.de</nlm:affiliation></affiliation></author><author><name sortKey="Hellwig, Dirk" sort="Hellwig, Dirk" uniqKey="Hellwig D" first="Dirk" last="Hellwig">Dirk Hellwig</name></author><author><name sortKey="Farmakis, Georgios" sort="Farmakis, Georgios" uniqKey="Farmakis G" first="Georgios" last="Farmakis">Georgios Farmakis</name></author><author><name sortKey="Jost, Wolfgang H" sort="Jost, Wolfgang H" uniqKey="Jost W" first="Wolfgang H" last="Jost">Wolfgang H. Jost</name></author><author><name sortKey="Samnick, Samuel" sort="Samnick, Samuel" uniqKey="Samnick S" first="Samuel" last="Samnick">Samuel Samnick</name></author><author><name sortKey="Fassbender, Klaus" sort="Fassbender, Klaus" uniqKey="Fassbender K" first="Klaus" last="Fassbender">Klaus Fassbender</name></author><author><name sortKey="Kirsch, Carl Martin" sort="Kirsch, Carl Martin" uniqKey="Kirsch C" first="Carl-Martin" last="Kirsch">Carl-Martin Kirsch</name></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21499</idno><idno type="RBID">pubmed:17427942</idno><idno type="pmid">17427942</idno><idno type="wicri:Area/PubMed/Corpus">002771</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease.</title><author><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name><affiliation><nlm:affiliation>Department of Neurology, Saarland University, D-66421 Homburg/Saar, Germany. nejspi@uniklinik-saarland.de</nlm:affiliation></affiliation></author><author><name sortKey="Hellwig, Dirk" sort="Hellwig, Dirk" uniqKey="Hellwig D" first="Dirk" last="Hellwig">Dirk Hellwig</name></author><author><name sortKey="Farmakis, Georgios" sort="Farmakis, Georgios" uniqKey="Farmakis G" first="Georgios" last="Farmakis">Georgios Farmakis</name></author><author><name sortKey="Jost, Wolfgang H" sort="Jost, Wolfgang H" uniqKey="Jost W" first="Wolfgang H" last="Jost">Wolfgang H. Jost</name></author><author><name sortKey="Samnick, Samuel" sort="Samnick, Samuel" uniqKey="Samnick S" first="Samuel" last="Samnick">Samuel Samnick</name></author><author><name sortKey="Fassbender, Klaus" sort="Fassbender, Klaus" uniqKey="Fassbender K" first="Klaus" last="Fassbender">Klaus Fassbender</name></author><author><name sortKey="Kirsch, Carl Martin" sort="Kirsch, Carl Martin" uniqKey="Kirsch C" first="Carl-Martin" last="Kirsch">Carl-Martin Kirsch</name></author><author><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Autonomic Nervous System Diseases (complications)</term><term>Autonomic Nervous System Diseases (pathology)</term><term>Autonomic Nervous System Diseases (radionuclide imaging)</term><term>Blood Pressure</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Iodine Radioisotopes (pharmacokinetics)</term><term>Male</term><term>Middle Aged</term><term>Myocardium (pathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Phenotype</term><term>Radionuclide Imaging (methods)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radionuclide Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Myocardium</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Iodine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Blood Pressure</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor-dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart-to-mediastinum (H/M) count-ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic-rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17427942</PMID><DateCreated><Year>2007</Year><Month>05</Month><Day>31</Day></DateCreated><DateCompleted><Year>2007</Year><Month>08</Month><Day>03</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>7</Issue><PubDate><Year>2007</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1004-8</MedlinePgn></Pagination><Abstract><AbstractText>In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor-dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart-to-mediastinum (H/M) count-ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic-rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor.</AbstractText><CopyrightInformation>(c) 2007 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Spiegel</LastName><ForeName>Jörg</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Saarland University, D-66421 Homburg/Saar, Germany. nejspi@uniklinik-saarland.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hellwig</LastName><ForeName>Dirk</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Farmakis</LastName><ForeName>Georgios</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Jost</LastName><ForeName>Wolfgang H</ForeName><Initials>WH</Initials></Author><Author ValidYN="Y"><LastName>Samnick</LastName><ForeName>Samuel</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Fassbender</LastName><ForeName>Klaus</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kirsch</LastName><ForeName>Carl-Martin</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Dillmann</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007457">Iodine Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001342">Autonomic Nervous System Diseases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001794">Blood Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007457">Iodine Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000176">diagnostic use</QualifierName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009206">Myocardium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010641">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011877">Radionuclide Imaging</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>4</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>8</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>4</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21499</ArticleId><ArticleId IdType="pubmed">17427942</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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