MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 001576

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Identifieur interne : 001576 ( PascalFrancis/Checkpoint ); précédent : 001575; suivant : 001577

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Auteurs : Jörg Spiegel [Allemagne] ; Dirk Hellwig [Allemagne] ; Georgios Farmakis [Allemagne] ; Wolfgang H. Jost [Allemagne] ; Samuel Samnick [Allemagne] ; Klaus Fassbender [Allemagne] ; Carl-Martin Kirsch [Allemagne] ; Ulrich Dillmann [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0314957

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Dégénérescence, Parkinson maladie, Phénotype, Scintigraphie.

English descriptors

KwdEn :
- Degeneration, Nervous system diseases, Parkinson disease, Phenotype, Scintigraphy.

Abstract

In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor-dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart-to-mediastinum (H/M) count-ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic-rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor.

Affiliations:

Allemagne

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<front><div type="abstract" xml:lang="en">In idiopathic Parkinson's disease (PD), different clinical subtypes are distinguished due to predominant motor symptoms: a tremor-dominant type (TDT), an akinetic rigid type (ART), and a mixed type (MT). We compared myocardial sympathetic innervation, measured by MIBG scintigraphy, in different subtypes of PD at early and advanced stages of PD. We applied MIBG scintigraphy in 102 patients with PD. About 57 patients were at Hoehn and Yahr (H&Y) stage 1, 22 at H&Y stage 2, and 23 at H&Y stages 3 and 4. For quantification of myocardial MIBG uptake, the heart-to-mediastinum (H/M) count-ratio was calculated. At all H&Y stages, myocardial MIBG uptake was significantly higher in TDT patients than in ART or MT patients (P < 0.05; ANOVA). Furthermore, at each H&Y stage, myocardial MIBG uptake correlated significantly with severity of hypokinesia (P < 0.05; Spearman's correlation) and rigidity (P < 0.05), but not with severity of resting or postural tremor. The significant correlation between myocardial sympathetic degeneration and severity of hypokinesia and rigidity suggests that myocardial sympathetic degeneration and hypokinetic-rigid symptoms develop in a closely coupled manner in early as well as advanced PD. No such correlation can be found between myocardial sympathetic degeneration and parkinsonian tremor.</div>
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<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>204</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Spiegel, Jorg" sort="Spiegel, Jorg" uniqKey="Spiegel J" first="Jörg" last="Spiegel">Jörg Spiegel</name>
</noRegion>
<name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name>
<name sortKey="Farmakis, Georgios" sort="Farmakis, Georgios" uniqKey="Farmakis G" first="Georgios" last="Farmakis">Georgios Farmakis</name>
<name sortKey="Fassbender, Klaus" sort="Fassbender, Klaus" uniqKey="Fassbender K" first="Klaus" last="Fassbender">Klaus Fassbender</name>
<name sortKey="Hellwig, Dirk" sort="Hellwig, Dirk" uniqKey="Hellwig D" first="Dirk" last="Hellwig">Dirk Hellwig</name>
<name sortKey="Jost, Wolfgang H" sort="Jost, Wolfgang H" uniqKey="Jost W" first="Wolfgang H." last="Jost">Wolfgang H. Jost</name>
<name sortKey="Kirsch, Carl Martin" sort="Kirsch, Carl Martin" uniqKey="Kirsch C" first="Carl-Martin" last="Kirsch">Carl-Martin Kirsch</name>
<name sortKey="Samnick, Samuel" sort="Samnick, Samuel" uniqKey="Samnick S" first="Samuel" last="Samnick">Samuel Samnick</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

Myocardial sympathetic degeneration correlates with clinical phenotype of Parkinson's disease

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