Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery
Identifieur interne : 004B87 ( Main/Curation ); précédent : 004B86; suivant : 004B88Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery
Auteurs : E. B. Jr Montgomery [États-Unis] ; W. C. Koller [États-Unis] ; T. J. K. Lamantia [États-Unis] ; M. C. Ii Newman [États-Unis] ; A. W. Kaszniak [États-Unis] ; K. Lyons [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Affect, Aged, Aged, 80 and over, Diagnosis, Differential, Early, Female, Human, Humans, Idiopathic, Male, Medical screening, Middle Aged, Mood, Motion, Neurologic Examination (statistics & numerical data), Olfaction, Parkinson Disease (diagnosis), Parkinson Disease (psychology), Parkinson disease, Performance evaluation, Personality Inventory (statistics & numerical data), Prospective Studies, Psychometrics, Reproducibility of Results.
- MESH :
- diagnosis : Parkinson Disease.
- psychology : Parkinson Disease.
- statistics & numerical data : Neurologic Examination, Personality Inventory.
- Adult, Affect, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Prospective Studies, Psychometrics, Reproducibility of Results.
Abstract
We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.
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Pascal:00-0269463Le document en format XML
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Development of a diagnostic test battery</title><author><name sortKey="Montgomery, E B Jr" sort="Montgomery, E B Jr" uniqKey="Montgomery E" first="E. B. Jr" last="Montgomery">E. B. Jr Montgomery</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Lamantia, T J K" sort="Lamantia, T J K" uniqKey="Lamantia T" first="T. J. K." last="Lamantia">T. J. K. Lamantia</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Newman, M C Ii" sort="Newman, M C Ii" uniqKey="Newman M" first="M. C. Ii" last="Newman">M. C. Ii Newman</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychology, The University of Arizona</s1><s2>Tucson, Arizona</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A. W." last="Kaszniak">A. W. Kaszniak</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Responsive Health Care</s1><s2>Overland Park, Kansas</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kansas</region></placeName></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychology, The University of Arizona</s1><s2>Tucson, Arizona</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Affect</term><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Early</term><term>Female</term><term>Human</term><term>Humans</term><term>Idiopathic</term><term>Male</term><term>Medical screening</term><term>Middle Aged</term><term>Mood</term><term>Motion</term><term>Neurologic Examination (statistics & numerical data)</term><term>Olfaction</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (psychology)</term><term>Parkinson disease</term><term>Performance evaluation</term><term>Personality Inventory (statistics & numerical data)</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neurologic Examination</term><term>Personality Inventory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Affect</term><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dépistage</term><term>Evaluation performance</term><term>Homme</term><term>Humeur</term><term>Mouvement</term><term>Olfaction</term><term>Parkinson maladie</term><term>Idiopathique</term><term>Olfaction</term><term>Humeur</term><term>Mouvement</term><term>Dépistage</term><term>Précoce</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</div></front></TEI><double idat="0885-3185:2000:Montgomery E:early:detection:of"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery</title><author><name sortKey="Montgomery, E B Jr" sort="Montgomery, E B Jr" uniqKey="Montgomery E" first="E. B. Jr" last="Montgomery">E. B. Jr Montgomery</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Lamantia, T J K" sort="Lamantia, T J K" uniqKey="Lamantia T" first="T. J. K." last="Lamantia">T. J. K. Lamantia</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Newman, M C Ii" sort="Newman, M C Ii" uniqKey="Newman M" first="M. C. Ii" last="Newman">M. C. Ii Newman</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychology, The University of Arizona</s1><s2>Tucson, Arizona</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A. W." last="Kaszniak">A. W. Kaszniak</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Responsive Health Care</s1><s2>Overland Park, Kansas</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kansas</region></placeName></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychology, The University of Arizona</s1><s2>Tucson, Arizona</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0269463</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0269463 INIST</idno><idno type="RBID">Pascal:00-0269463</idno><idno type="wicri:Area/PascalFrancis/Corpus">002C09</idno><idno type="wicri:Area/PascalFrancis/Curation">000112</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002C14</idno><idno type="wicri:doubleKey">0885-3185:2000:Montgomery E:early:detection:of</idno><idno type="wicri:Area/Main/Merge">007606</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery</title><author><name sortKey="Montgomery, E B Jr" sort="Montgomery, E B Jr" uniqKey="Montgomery E" first="E. B. Jr" last="Montgomery">E. B. Jr Montgomery</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Lamantia, T J K" sort="Lamantia, T J K" uniqKey="Lamantia T" first="T. J. K." last="Lamantia">T. J. K. Lamantia</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Newman, M C Ii" sort="Newman, M C Ii" uniqKey="Newman M" first="M. C. Ii" last="Newman">M. C. Ii Newman</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychology, The University of Arizona</s1><s2>Tucson, Arizona</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A. W." last="Kaszniak">A. W. Kaszniak</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Responsive Health Care</s1><s2>Overland Park, Kansas</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Kansas</region></placeName></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Psychology, The University of Arizona</s1><s2>Tucson, Arizona</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Arizona</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Early</term><term>Human</term><term>Idiopathic</term><term>Medical screening</term><term>Mood</term><term>Motion</term><term>Olfaction</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Idiopathique</term><term>Olfaction</term><term>Humeur</term><term>Mouvement</term><term>Dépistage</term><term>Précoce</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</div></front></TEI></INIST><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Early detection of probable idiopathic Parkinson's disease : II. A prospective application of a diagnostic test battery</title><author><name sortKey="Montgomery, E B Jr" sort="Montgomery, E B Jr" uniqKey="Montgomery E" first="E. B. Jr" last="Montgomery">E. B. Jr Montgomery</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Departments of Neurology and Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0271640</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0271640 INIST</idno><idno type="RBID">Pascal:00-0271640</idno><idno type="wicri:Area/PascalFrancis/Corpus">002B97</idno><idno type="wicri:Area/PascalFrancis/Curation">000124</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002C13</idno><idno type="wicri:doubleKey">0885-3185:2000:Montgomery E:early:detection:of</idno><idno type="wicri:Area/Main/Merge">007605</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Early detection of probable idiopathic Parkinson's disease : II. A prospective application of a diagnostic test battery</title><author><name sortKey="Montgomery, E B Jr" sort="Montgomery, E B Jr" uniqKey="Montgomery E" first="E. B. Jr" last="Montgomery">E. B. Jr Montgomery</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Departments of Neurology and Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>National Parkinson Foundation, University of Miami Medical Center</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Early</term><term>Human</term><term>Medical screening</term><term>Mood</term><term>Motion</term><term>Olfaction</term><term>Parkinson disease</term><term>Performance evaluation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Olfaction</term><term>Mouvement</term><term>Humeur</term><term>Evaluation performance</term><term>Dépistage</term><term>Précoce</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We developed a battery of tests, incorporating motor function, olfaction, and mood, that distinguishes between early mild, probable idiopathic Parkinson's disease (iPD), and normal control subjects. Here, we determined the PD Battery's ability to prospectively identify which patients with symptoms and signs suggestive of, but not yet diagnostic of, iPD who would subsequently be diagnosed as having iPD. Of 212 enrolled patients, 194 have been followed for at least 1 year. Among these 194, 59 were diagnosed with iPD, 40 as neurologically normal, and the remaining 106 with other neurologic conditions such as essential tremor. The test battery was 92% specific and 68% sensitive for iPD. The area under the Receiver Operating Characteristics curve was 0.88 for predicting which participants would subsequently be diagnosed as having iPD or as being neurologically normal.</div></front></TEI></INIST><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery.</title><author><name sortKey="Montgomery, E B" sort="Montgomery, E B" uniqKey="Montgomery E" first="E B" last="Montgomery">E B Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W C" last="Koller">W C Koller</name></author><author><name sortKey="Lamantia, T J" sort="Lamantia, T J" uniqKey="Lamantia T" first="T J" last="Lamantia">T J Lamantia</name></author><author><name sortKey="Newman, M C" sort="Newman, M C" uniqKey="Newman M" first="M C" last="Newman">M C Newman</name></author><author><name sortKey="Swanson Hyland, E" sort="Swanson Hyland, E" uniqKey="Swanson Hyland E" first="E" last="Swanson-Hyland">E. Swanson-Hyland</name></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A W" last="Kaszniak">A W Kaszniak</name></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10830410</idno><idno type="pmid">10830410</idno><idno type="wicri:Area/PubMed/Corpus">003F82</idno><idno type="wicri:Area/PubMed/Curation">003F82</idno><idno type="wicri:Area/PubMed/Checkpoint">003F93</idno><idno type="wicri:Area/Ncbi/Merge">000269</idno><idno type="wicri:Area/Ncbi/Curation">000269</idno><idno type="wicri:Area/Ncbi/Checkpoint">000269</idno><idno type="wicri:doubleKey">0885-3185:2000:Montgomery E:early:detection:of</idno><idno type="wicri:Area/Main/Merge">007136</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery.</title><author><name sortKey="Montgomery, E B" sort="Montgomery, E B" uniqKey="Montgomery E" first="E B" last="Montgomery">E B Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W C" last="Koller">W C Koller</name></author><author><name sortKey="Lamantia, T J" sort="Lamantia, T J" uniqKey="Lamantia T" first="T J" last="Lamantia">T J Lamantia</name></author><author><name sortKey="Newman, M C" sort="Newman, M C" uniqKey="Newman M" first="M C" last="Newman">M C Newman</name></author><author><name sortKey="Swanson Hyland, E" sort="Swanson Hyland, E" uniqKey="Swanson Hyland E" first="E" last="Swanson-Hyland">E. Swanson-Hyland</name></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A W" last="Kaszniak">A W Kaszniak</name></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Affect</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (statistics & numerical data)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (psychology)</term><term>Personality Inventory (statistics & numerical data)</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neurologic Examination</term><term>Personality Inventory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Affect</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</div></front></TEI></PubMed><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early detection of probable idiopathic Parkinson's disease: II. A prospective application of a diagnostic test battery.</title><author><name sortKey="Montgomery, E B" sort="Montgomery, E B" uniqKey="Montgomery E" first="E B" last="Montgomery">E B Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W C" last="Koller">W C Koller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10830411</idno><idno type="pmid">10830411</idno><idno type="wicri:Area/PubMed/Corpus">003F81</idno><idno type="wicri:Area/PubMed/Curation">003F81</idno><idno type="wicri:Area/PubMed/Checkpoint">003F92</idno><idno type="wicri:Area/Ncbi/Merge">000270</idno><idno type="wicri:Area/Ncbi/Curation">000270</idno><idno type="wicri:Area/Ncbi/Checkpoint">000270</idno><idno type="wicri:doubleKey">0885-3185:2000:Montgomery E:early:detection:of</idno><idno type="wicri:Area/Main/Merge">007135</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early detection of probable idiopathic Parkinson's disease: II. A prospective application of a diagnostic test battery.</title><author><name sortKey="Montgomery, E B" sort="Montgomery, E B" uniqKey="Montgomery E" first="E B" last="Montgomery">E B Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W C" last="Koller">W C Koller</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (statistics & numerical data)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (psychology)</term><term>Personality Inventory (statistics & numerical data)</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neurologic Examination</term><term>Personality Inventory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We developed a battery of tests, incorporating motor function, olfaction, and mood, that distinguishes between early mild, probable idiopathic Parkinson's disease (iPD), and normal control subjects. Here, we determined the PD Battery's ability to prospectively identify which patients with symptoms and signs suggestive of, but not yet diagnostic of, iPD who would subsequently be diagnosed as having iPD. Of 212 enrolled patients, 194 have been followed for at least 1 year. Among these 194, 59 were diagnosed with iPD, 40 as neurologically normal, and the remaining 106 with other neurologic conditions such as essential tremor. The test battery was 92% specific and 68% sensitive for iPD. The area under the Receiver Operating Characteristics curve was 0.88 for predicting which participants would subsequently be diagnosed as having iPD or as being neurologically normal.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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