Movement Disorders (revue)

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Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery

Identifieur interne : 000112 ( PascalFrancis/Curation ); précédent : 000111; suivant : 000113

Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery

Auteurs : E. B. Jr Montgomery [États-Unis] ; W. C. Koller [États-Unis] ; T. J. K. Lamantia [États-Unis] ; M. C. Ii Newman [États-Unis] ; A. W. Kaszniak [États-Unis] ; K. Lyons [États-Unis]

Source :

RBID : Pascal:00-0269463

Descripteurs français

English descriptors

Abstract

We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.
pA  
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A03   1    @0 Mov. disord.
A05       @2 15
A06       @2 3
A08 01  1  ENG  @1 Early detection of probable idiopathic Parkinson's disease : I. Development of a diagnostic test battery
A11 01  1    @1 MONTGOMERY (E. B. JR)
A11 02  1    @1 KOLLER (W. C.)
A11 03  1    @1 LAMANTIA (T. J. K.)
A11 04  1    @1 NEWMAN (M. C. II)
A11 05  1    @1 KASZNIAK (A. W.)
A11 06  1    @1 LYONS (K.)
A14 01      @1 Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation @2 Cleveland, Ohio @3 USA @Z 1 aut.
A14 02      @1 National Parkinson Foundation, University of Miami Medical Center @2 Miami, Florida @3 USA @Z 2 aut. @Z 6 aut.
A14 03      @1 Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation @2 Cleveland, Ohio @3 USA @Z 3 aut.
A14 04      @1 Department of Psychology, The University of Arizona @2 Tucson, Arizona @3 USA @Z 4 aut. @Z 6 aut.
A14 05      @1 Responsive Health Care @2 Overland Park, Kansas @3 USA @Z 5 aut.
A20       @1 467-473
A21       @1 2000
A23 01      @0 ENG
A43 01      @1 INIST @2 20953 @5 354000087348900060
A44       @0 0000 @1 © 2000 INIST-CNRS. All rights reserved.
A45       @0 29 ref.
A47 01  1    @0 00-0269463
A60       @1 P
A61       @0 A
A64 01  1    @0 Movement disorders
A66 01      @0 USA
C01 01    ENG  @0 We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.
C02 01  X    @0 002B17G
C03 01  X  FRE  @0 Parkinson maladie @5 01
C03 01  X  ENG  @0 Parkinson disease @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @5 01
C03 02  X  FRE  @0 Idiopathique @5 02
C03 02  X  ENG  @0 Idiopathic @5 02
C03 02  X  SPA  @0 Idiopático @5 02
C03 03  X  FRE  @0 Olfaction @5 04
C03 03  X  ENG  @0 Olfaction @5 04
C03 03  X  SPA  @0 Olfación @5 04
C03 04  X  FRE  @0 Humeur @5 07
C03 04  X  ENG  @0 Mood @5 07
C03 04  X  SPA  @0 Humor @5 07
C03 05  X  FRE  @0 Mouvement @5 10
C03 05  X  ENG  @0 Motion @5 10
C03 05  X  SPA  @0 Movimiento @5 10
C03 06  X  FRE  @0 Dépistage @5 17
C03 06  X  ENG  @0 Medical screening @5 17
C03 06  X  SPA  @0 Descubrimiento @5 17
C03 07  X  FRE  @0 Précoce @5 18
C03 07  X  ENG  @0 Early @5 18
C03 07  X  SPA  @0 Precoz @5 18
C03 08  X  FRE  @0 Homme @5 20
C03 08  X  ENG  @0 Human @5 20
C03 08  X  SPA  @0 Hombre @5 20
C07 01  X  FRE  @0 Système nerveux pathologie @5 37
C07 01  X  ENG  @0 Nervous system diseases @5 37
C07 01  X  SPA  @0 Sistema nervioso patología @5 37
C07 02  X  FRE  @0 Système nerveux central pathologie @5 38
C07 02  X  ENG  @0 Central nervous system disease @5 38
C07 02  X  SPA  @0 Sistema nervosio central patología @5 38
C07 03  X  FRE  @0 Encéphale pathologie @5 39
C07 03  X  ENG  @0 Cerebral disorder @5 39
C07 03  X  SPA  @0 Encéfalo patología @5 39
C07 04  X  FRE  @0 Extrapyramidal syndrome @5 40
C07 04  X  ENG  @0 Extrapyramidal syndrome @5 40
C07 04  X  SPA  @0 Extrapiramidal síndrome @5 40
C07 05  X  FRE  @0 Maladie dégénérative @5 41
C07 05  X  ENG  @0 Degenerative disease @5 41
C07 05  X  SPA  @0 Enfermedad degenerativa @5 41
N21       @1 185

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Pascal:00-0269463

Le document en format XML

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<div type="abstract" xml:lang="en">We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</div>
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<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fN21>
<s1>185</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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