Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery.
Identifieur interne : 000269 ( Ncbi/Curation ); précédent : 000268; suivant : 000270Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery.
Auteurs : E B Montgomery [États-Unis] ; W C Koller ; T J Lamantia ; M C Newman ; E. Swanson-Hyland ; A W Kaszniak ; K. LyonsSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Adult, Affect, Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Neurologic Examination (statistics & numerical data), Parkinson Disease (diagnosis), Parkinson Disease (psychology), Personality Inventory (statistics & numerical data), Prospective Studies, Psychometrics, Reproducibility of Results.
- MESH :
- diagnosis : Parkinson Disease.
- psychology : Parkinson Disease.
- statistics & numerical data : Neurologic Examination, Personality Inventory.
- Adult, Affect, Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Prospective Studies, Psychometrics, Reproducibility of Results.
Abstract
We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.
PubMed: 10830410
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Development of a diagnostic test battery.</title><author><name sortKey="Montgomery, E B" sort="Montgomery, E B" uniqKey="Montgomery E" first="E B" last="Montgomery">E B Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W C" last="Koller">W C Koller</name></author><author><name sortKey="Lamantia, T J" sort="Lamantia, T J" uniqKey="Lamantia T" first="T J" last="Lamantia">T J Lamantia</name></author><author><name sortKey="Newman, M C" sort="Newman, M C" uniqKey="Newman M" first="M C" last="Newman">M C Newman</name></author><author><name sortKey="Swanson Hyland, E" sort="Swanson Hyland, E" uniqKey="Swanson Hyland E" first="E" last="Swanson-Hyland">E. Swanson-Hyland</name></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A W" last="Kaszniak">A W Kaszniak</name></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10830410</idno><idno type="pmid">10830410</idno><idno type="wicri:Area/PubMed/Corpus">003F82</idno><idno type="wicri:Area/PubMed/Curation">003F82</idno><idno type="wicri:Area/PubMed/Checkpoint">003F93</idno><idno type="wicri:Area/Ncbi/Merge">000269</idno><idno type="wicri:Area/Ncbi/Curation">000269</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery.</title><author><name sortKey="Montgomery, E B" sort="Montgomery, E B" uniqKey="Montgomery E" first="E B" last="Montgomery">E B Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195</wicri:regionArea><wicri:noRegion>Ohio 44195</wicri:noRegion></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W C" last="Koller">W C Koller</name></author><author><name sortKey="Lamantia, T J" sort="Lamantia, T J" uniqKey="Lamantia T" first="T J" last="Lamantia">T J Lamantia</name></author><author><name sortKey="Newman, M C" sort="Newman, M C" uniqKey="Newman M" first="M C" last="Newman">M C Newman</name></author><author><name sortKey="Swanson Hyland, E" sort="Swanson Hyland, E" uniqKey="Swanson Hyland E" first="E" last="Swanson-Hyland">E. Swanson-Hyland</name></author><author><name sortKey="Kaszniak, A W" sort="Kaszniak, A W" uniqKey="Kaszniak A" first="A W" last="Kaszniak">A W Kaszniak</name></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K" last="Lyons">K. Lyons</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Affect</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (statistics & numerical data)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (psychology)</term><term>Personality Inventory (statistics & numerical data)</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neurologic Examination</term><term>Personality Inventory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Affect</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Psychometrics</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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