Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Identifieur interne : 001894 ( Main/Exploration ); précédent : 001893; suivant : 001895Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Auteurs : Eva Fries [Allemagne, Canada] ; Nathalie Moragues [Canada] ; Christian Caldji [Canada] ; Dirk H. Hellhammer [Allemagne] ; Michael J. Meaney [Canada]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
English descriptors
- KwdEn :
- Animals, Appetitive Behavior (drug effects), Benzodiazepines (pharmacology), Diazepam (pharmacology), GABA Modulators (pharmacology), GABAA receptor, Grooming, Male, Maternal Behavior (physiology), Rats, Rats, Long-Evans, Receptors, GABA-A (biosynthesis), Receptors, GABA-A (drug effects), Receptors, GABA-A (genetics), benzodiazepine receptor, benzodiazepine sensitivity, fear/anxiety, maternal care, novelty‐induced suppression of appetitive behavior, rat.
- MESH :
- chemical , biosynthesis : Receptors, GABA-A.
- chemical , drug effects : Receptors, GABA-A.
- chemical , genetics : Receptors, GABA-A.
- chemical , pharmacology : Benzodiazepines, Diazepam, GABA Modulators.
- drug effects : Appetitive Behavior.
- physiology : Maternal Behavior.
- Animals, Grooming, Male, Rats, Rats, Long-Evans.
Abstract
Abstract: Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABAA/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.
Url:
DOI: 10.1196/annals.1314.051
Affiliations:
- Allemagne, Canada
- Québec, Rhénanie-Palatinat
- Montréal, Trèves (Allemagne)
- Université McGill, Université de Trèves
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Le document en format XML
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Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>Québec</li><li>Rhénanie-Palatinat</li></region><settlement><li>Montréal</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université McGill</li><li>Université de Trèves</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name></region><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name></country><country name="Canada"><noRegion><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name></noRegion><name sortKey="Caldji, Christian" sort="Caldji, Christian" uniqKey="Caldji C" first="Christian" last="Caldji">Christian Caldji</name><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J." last="Meaney">Michael J. Meaney</name><name sortKey="Moragues, Nathalie" sort="Moragues, Nathalie" uniqKey="Moragues N" first="Nathalie" last="Moragues">Nathalie Moragues</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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