Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Identifieur interne : 000964 ( Istex/Checkpoint ); précédent : 000963; suivant : 000965Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Auteurs : Eva Fries [Allemagne, Canada] ; Nathalie Moragues [Canada] ; Christian Caldji [Canada] ; Dirk H. Hellhammer [Allemagne] ; Michael J. Meaney [Canada]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
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Abstract
Abstract: Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABAA/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.
Url:
DOI: 10.1196/annals.1314.051
Affiliations:
- Allemagne, Canada
- Québec, Rhénanie-Palatinat
- Montréal, Trèves (Allemagne)
- Université McGill, Université de Trèves
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ISTEX:728742271B2FEBA248226EF8F3EE7DBD0DD1C521Le document en format XML
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