Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.
Identifieur interne : 000187 ( Ncbi/Merge ); précédent : 000186; suivant : 000188Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.
Auteurs : Eva Fries [Allemagne] ; Nathalie Moragues ; Christian Caldji ; Dirk H. Hellhammer ; Michael J. MeaneySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Appetitive Behavior (drug effects), Benzodiazepines (pharmacology), Diazepam (pharmacology), GABA Modulators (pharmacology), Grooming, Male, Maternal Behavior (physiology), Rats, Rats, Long-Evans, Receptors, GABA-A (biosynthesis), Receptors, GABA-A (drug effects), Receptors, GABA-A (genetics).
- MESH :
- chemical , biosynthesis : Receptors, GABA-A.
- chemical , drug effects : Receptors, GABA-A.
- chemical , genetics : Receptors, GABA-A.
- chemical , pharmacology : Benzodiazepines, Diazepam, GABA Modulators.
- drug effects : Appetitive Behavior.
- physiology : Maternal Behavior.
- Animals, Grooming, Male, Rats, Rats, Long-Evans.
Abstract
Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABA(A)/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched-back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming-arched-back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.
DOI: 10.1196/annals.1314.051
PubMed: 15677441
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000724
- to stream PubMed, to step Curation: 000724
- to stream PubMed, to step Checkpoint: 000724
Links to Exploration step
pubmed:15677441Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.</title>
<author><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Clinical and Theoretical Psychobiology, University of Trier, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Clinical and Theoretical Psychobiology, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Moragues, Nathalie" sort="Moragues, Nathalie" uniqKey="Moragues N" first="Nathalie" last="Moragues">Nathalie Moragues</name>
</author>
<author><name sortKey="Caldji, Christian" sort="Caldji, Christian" uniqKey="Caldji C" first="Christian" last="Caldji">Christian Caldji</name>
</author>
<author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name>
</author>
<author><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2004">2004</date>
<idno type="RBID">pubmed:15677441</idno>
<idno type="pmid">15677441</idno>
<idno type="doi">10.1196/annals.1314.051</idno>
<idno type="wicri:Area/PubMed/Corpus">000724</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000724</idno>
<idno type="wicri:Area/PubMed/Curation">000724</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000724</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000724</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000724</idno>
<idno type="wicri:Area/Ncbi/Merge">000187</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.</title>
<author><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Clinical and Theoretical Psychobiology, University of Trier, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Clinical and Theoretical Psychobiology, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Moragues, Nathalie" sort="Moragues, Nathalie" uniqKey="Moragues N" first="Nathalie" last="Moragues">Nathalie Moragues</name>
</author>
<author><name sortKey="Caldji, Christian" sort="Caldji, Christian" uniqKey="Caldji C" first="Christian" last="Caldji">Christian Caldji</name>
</author>
<author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name>
</author>
<author><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name>
</author>
</analytic>
<series><title level="j">Annals of the New York Academy of Sciences</title>
<idno type="ISSN">0077-8923</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Appetitive Behavior (drug effects)</term>
<term>Benzodiazepines (pharmacology)</term>
<term>Diazepam (pharmacology)</term>
<term>GABA Modulators (pharmacology)</term>
<term>Grooming</term>
<term>Male</term>
<term>Maternal Behavior (physiology)</term>
<term>Rats</term>
<term>Rats, Long-Evans</term>
<term>Receptors, GABA-A (biosynthesis)</term>
<term>Receptors, GABA-A (drug effects)</term>
<term>Receptors, GABA-A (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, GABA-A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, GABA-A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, GABA-A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzodiazepines</term>
<term>Diazepam</term>
<term>GABA Modulators</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Appetitive Behavior</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Maternal Behavior</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Grooming</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Long-Evans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABA(A)/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched-back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming-arched-back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15677441</PMID>
<DateCreated><Year>2005</Year>
<Month>01</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2005</Year>
<Month>04</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0077-8923</ISSN>
<JournalIssue CitedMedium="Print"><Volume>1032</Volume>
<PubDate><Year>2004</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Annals of the New York Academy of Sciences</Title>
<ISOAbbreviation>Ann. N. Y. Acad. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.</ArticleTitle>
<Pagination><MedlinePgn>320-3</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABA(A)/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched-back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming-arched-back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fries</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Clinical and Theoretical Psychobiology, University of Trier, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moragues</LastName>
<ForeName>Nathalie</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Caldji</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hellhammer</LastName>
<ForeName>Dirk H</ForeName>
<Initials>DH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Meaney</LastName>
<ForeName>Michael J</ForeName>
<Initials>MJ</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Ann N Y Acad Sci</MedlineTA>
<NlmUniqueID>7506858</NlmUniqueID>
<ISSNLinking>0077-8923</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018757">GABA Modulators</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011963">Receptors, GABA-A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>12794-10-4</RegistryNumber>
<NameOfSubstance UI="D001569">Benzodiazepines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>Q3JTX2Q7TU</RegistryNumber>
<NameOfSubstance UI="D003975">Diazepam</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001070" MajorTopicYN="N">Appetitive Behavior</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001569" MajorTopicYN="N">Benzodiazepines</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003975" MajorTopicYN="N">Diazepam</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018757" MajorTopicYN="N">GABA Modulators</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006120" MajorTopicYN="N">Grooming</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008425" MajorTopicYN="N">Maternal Behavior</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020318" MajorTopicYN="N">Rats, Long-Evans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011963" MajorTopicYN="N">Receptors, GABA-A</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>1</Month>
<Day>29</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>4</Month>
<Day>20</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>1</Month>
<Day>29</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15677441</ArticleId>
<ArticleId IdType="pii">1032/1/320</ArticleId>
<ArticleId IdType="doi">10.1196/annals.1314.051</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Rhénanie-Palatinat</li>
</region>
<settlement><li>Trèves (Allemagne)</li>
</settlement>
<orgName><li>Université de Trèves</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Caldji, Christian" sort="Caldji, Christian" uniqKey="Caldji C" first="Christian" last="Caldji">Christian Caldji</name>
<name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name>
<name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name>
<name sortKey="Moragues, Nathalie" sort="Moragues, Nathalie" uniqKey="Moragues N" first="Nathalie" last="Moragues">Nathalie Moragues</name>
</noCountry>
<country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000187 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000187 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Rhénanie |area= UnivTrevesV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:15677441 |texte= Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:15677441" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a UnivTrevesV1
This area was generated with Dilib version V0.6.31. |