Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Identifieur interne : 000518 ( Istex/Corpus ); précédent : 000517; suivant : 000519Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Auteurs : Eva Fries ; Nathalie Moragues ; Christian Caldji ; Dirk H. Hellhammer ; Michael J. MeaneySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
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Abstract
Abstract: Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABAA/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.
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DOI: 10.1196/annals.1314.051
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Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. 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Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. 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Effects of Stress and Stress Hormones: Animal Studies</title></titleGroup><eventGroup><event type="firstOnline" date="2006-01-12"></event><event type="publishedOnlineFinalForm" date="2009-07-08"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-02-27"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="320">320</numbering><numbering type="pageLast" number="323">323</numbering></numberingGroup><correspondenceTo>Address for correspondence: Michael J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, 6875 boulevard La Salle Montreal, Quebec H4H‐1R3, Canada. Voice: +1‐514‐761‐6131; fax: +1‐515‐762‐3034. <email>Michael.meaney@mcgill.ca</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS320.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="7"></count><count type="linksCrossRef" number="15"></count></countGroup><titleGroup><title type="main">Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>EVA</givenNames><familyName>FRIES</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>NATHALIE</givenNames><familyName>MORAGUES</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>CHRISTIAN</givenNames><familyName>CALDJI</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>DIRK H.</givenNames><familyName>HELLHAMMER</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>MICHAEL J.</givenNames><familyName>MEANEY</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Clinical and Theoretical Psychobiology, University of Trier, Trier, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="CA"><unparsedAffiliation>Douglas Hospital Research Center, Departments of Psychiatry and Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">GABA<sub>A</sub> receptor</keyword><keyword xml:id="k2">benzodiazepine receptor</keyword><keyword xml:id="k3">benzodiazepine sensitivity</keyword><keyword xml:id="k4">maternal care</keyword><keyword xml:id="k5">rat</keyword><keyword xml:id="k6">fear/anxiety</keyword><keyword xml:id="k7">novelty‐induced suppression of appetitive behavior</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>A<sc>bstract</sc>: </b> Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABA<sub>A</sub>/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat</title></titleInfo><name type="personal"><namePart type="given">EVA</namePart><namePart type="family">FRIES</namePart><affiliation>Department of Clinical and Theoretical Psychobiology, University of Trier, Trier, Germany</affiliation><affiliation>E-mail: Michael.meaney@mcgill.ca</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NATHALIE</namePart><namePart type="family">MORAGUES</namePart><affiliation>Douglas Hospital Research Center, Departments of Psychiatry and Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CHRISTIAN</namePart><namePart type="family">CALDJI</namePart><affiliation>Douglas Hospital Research Center, Departments of Psychiatry and Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DIRK H.</namePart><namePart type="family">HELLHAMMER</namePart><affiliation>Department of Clinical and Theoretical Psychobiology, University of Trier, Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MICHAEL J.</namePart><namePart type="family">MEANEY</namePart><affiliation>Douglas Hospital Research Center, Departments of Psychiatry and Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2004-12</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="references">7</extent></physicalDescription><abstract>Abstract: Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABAA/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</abstract><subject lang="en"><genre>keywords</genre><topic>GABAA receptor</topic><topic>benzodiazepine receptor</topic><topic>benzodiazepine sensitivity</topic><topic>maternal care</topic><topic>rat</topic><topic>fear/anxiety</topic><topic>novelty‐induced suppression of appetitive behavior</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2004</date><detail type="title"><title>Biobehavioral Stress Response: Protective and Damaging Effects</title></detail><detail type="volume"><caption>vol.</caption><number>1032</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>320</start><end>323</end><total>4</total></extent></part></relatedItem><identifier type="istex">728742271B2FEBA248226EF8F3EE7DBD0DD1C521</identifier><identifier type="DOI">10.1196/annals.1314.051</identifier><identifier type="ArticleID">NYAS320</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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