Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.
Identifieur interne : 000187 ( Ncbi/Checkpoint ); précédent : 000186; suivant : 000188Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat.
Auteurs : Eva Fries [Allemagne] ; Nathalie Moragues ; Christian Caldji ; Dirk H. Hellhammer ; Michael J. MeaneySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Appetitive Behavior (drug effects), Benzodiazepines (pharmacology), Diazepam (pharmacology), GABA Modulators (pharmacology), Grooming, Male, Maternal Behavior (physiology), Rats, Rats, Long-Evans, Receptors, GABA-A (biosynthesis), Receptors, GABA-A (drug effects), Receptors, GABA-A (genetics).
- MESH :
- chemical , biosynthesis : Receptors, GABA-A.
- chemical , drug effects : Receptors, GABA-A.
- chemical , genetics : Receptors, GABA-A.
- chemical , pharmacology : Benzodiazepines, Diazepam, GABA Modulators.
- drug effects : Appetitive Behavior.
- physiology : Maternal Behavior.
- Animals, Grooming, Male, Rats, Rats, Long-Evans.
Abstract
Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABA(A)/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched-back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming-arched-back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.
DOI: 10.1196/annals.1314.051
PubMed: 15677441
Affiliations:
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pubmed:15677441Le document en format XML
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Hellhammer</name></author><author><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. 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Hellhammer</name></author><author><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Appetitive Behavior (drug effects)</term><term>Benzodiazepines (pharmacology)</term><term>Diazepam (pharmacology)</term><term>GABA Modulators (pharmacology)</term><term>Grooming</term><term>Male</term><term>Maternal Behavior (physiology)</term><term>Rats</term><term>Rats, Long-Evans</term><term>Receptors, GABA-A (biosynthesis)</term><term>Receptors, GABA-A (drug effects)</term><term>Receptors, GABA-A (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, GABA-A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, GABA-A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, GABA-A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzodiazepines</term><term>Diazepam</term><term>GABA Modulators</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Appetitive Behavior</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Maternal Behavior</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Grooming</term><term>Male</term><term>Rats</term><term>Rats, Long-Evans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABA(A)/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched-back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming-arched-back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Caldji, Christian" sort="Caldji, Christian" uniqKey="Caldji C" first="Christian" last="Caldji">Christian Caldji</name><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name><name sortKey="Moragues, Nathalie" sort="Moragues, Nathalie" uniqKey="Moragues N" first="Nathalie" last="Moragues">Nathalie Moragues</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Fries, Eva" sort="Fries, Eva" uniqKey="Fries E" first="Eva" last="Fries">Eva Fries</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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