Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Identifieur interne : 001894 ( Main/Curation ); précédent : 001893; suivant : 001895Preliminary Evidence of Altered Sensitivity to Benzodiazepines as a Function of Maternal Care in the Rat
Auteurs : Eva Fries [Allemagne, Canada] ; Nathalie Moragues [Canada] ; Christian Caldji [Canada] ; Dirk H. Hellhammer [Allemagne] ; Michael J. Meaney [Canada]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
English descriptors
- KwdEn :
- Animals, Appetitive Behavior (drug effects), Benzodiazepines (pharmacology), Diazepam (pharmacology), GABA Modulators (pharmacology), GABAA receptor, Grooming, Male, Maternal Behavior (physiology), Rats, Rats, Long-Evans, Receptors, GABA-A (biosynthesis), Receptors, GABA-A (drug effects), Receptors, GABA-A (genetics), benzodiazepine receptor, benzodiazepine sensitivity, fear/anxiety, maternal care, novelty‐induced suppression of appetitive behavior, rat.
- MESH :
- chemical , biosynthesis : Receptors, GABA-A.
- chemical , drug effects : Receptors, GABA-A.
- chemical , genetics : Receptors, GABA-A.
- chemical , pharmacology : Benzodiazepines, Diazepam, GABA Modulators.
- drug effects : Appetitive Behavior.
- physiology : Maternal Behavior.
- Animals, Grooming, Male, Rats, Rats, Long-Evans.
Abstract
Abstract: Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABAA/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.
Url:
DOI: 10.1196/annals.1314.051
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<front><div type="abstract">Abstract: Variations in maternal care over the first week of life alter the expression of genes encoding for various subunits of the GABAA/benzodiazepine (BZ) receptor in the amygdala, a brain region associated with fear behavior. Increased maternal licking/grooming and arched‐back nursing are associated with decreased fearfulness and enhanced expression of the subunits that confer BZ sensitivity. In these studies we found that the offspring of high licking/grooming‐arched‐back nursing mothers also showed increased behavioral sensitivity to acute BZ treatment, suggesting a functional relation between the effect on gene expression and fear behavior.</div>
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