Effect of fenfluramine on episodic ACTH and cortisol secretion
Identifieur interne : 002785 ( Main/Exploration ); précédent : 002784; suivant : 002786Effect of fenfluramine on episodic ACTH and cortisol secretion
Auteurs : Thomas H. Schürmeyer [Allemagne] ; Götz Brademann [Allemagne] ; Alexander Von Zur Mühlen [Allemagne]Source :
- Clinical Endocrinology [ 0300-0664 ] ; 1996-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- ACTH, Adrenocorticotropic Hormone (blood), Adrenocorticotropic Hormone (secretion), Adult, Amphetamine derivatives, Assay, Corticotropin-Releasing Hormone, Cortisol, Data Interpretation, Statistical, Fenfluramine (blood), Fenfluramine (pharmacology), Human, Humans, Hydrocortisone (blood), Hydrocortisone (secretion), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (secretion), Hypothalamohypophysoadrenal axis, Male, Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (secretion), Secretion, Serotonin, Serotonin Uptake Inhibitors (blood), Serotonin Uptake Inhibitors (pharmacology), Urine.
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Fenfluramine, Hydrocortisone, Serotonin Uptake Inhibitors.
- chemical , pharmacology : Fenfluramine, Serotonin Uptake Inhibitors.
- chemical , secretion : Adrenocorticotropic Hormone, Hydrocortisone.
- drug effects : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- secretion : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Adult, Corticotropin-Releasing Hormone, Data Interpretation, Statistical, Humans, Male.
Abstract
OBJECTIVE The central serotoninergic system is known to modulate the activity of the hypothalamic‐pituitary‐adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic‐pituitary‐adrenal axis in healthy controls.
Url:
DOI: 10.1111/j.1365-2265.1996.tb02058.x
Affiliations:
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Le document en format XML
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<term>Adult</term>
<term>Amphetamine derivatives</term>
<term>Assay</term>
<term>Corticotropin-Releasing Hormone</term>
<term>Cortisol</term>
<term>Data Interpretation, Statistical</term>
<term>Fenfluramine (blood)</term>
<term>Fenfluramine (pharmacology)</term>
<term>Human</term>
<term>Humans</term>
<term>Hydrocortisone (blood)</term>
<term>Hydrocortisone (secretion)</term>
<term>Hypothalamo-Hypophyseal System (drug effects)</term>
<term>Hypothalamo-Hypophyseal System (secretion)</term>
<term>Hypothalamohypophysoadrenal axis</term>
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<term>Pituitary-Adrenal System (drug effects)</term>
<term>Pituitary-Adrenal System (secretion)</term>
<term>Secretion</term>
<term>Serotonin</term>
<term>Serotonin Uptake Inhibitors (blood)</term>
<term>Serotonin Uptake Inhibitors (pharmacology)</term>
<term>Urine</term>
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<term>Serotonin Uptake Inhibitors</term>
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<term>Hydrocortisone</term>
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<term>Pituitary-Adrenal System</term>
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<term>Système hypothalamohypophysosurrénalien</term>
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<front><div type="abstract">OBJECTIVE The central serotoninergic system is known to modulate the activity of the hypothalamic‐pituitary‐adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic‐pituitary‐adrenal axis in healthy controls.</div>
</front>
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