Effect of fenfluramine on episodic ACTH and cortisol secretion.
Identifieur interne : 000B17 ( Ncbi/Curation ); précédent : 000B16; suivant : 000B18Effect of fenfluramine on episodic ACTH and cortisol secretion.
Auteurs : T H Schürmeyer [Allemagne] ; G. Brademann ; A. Von Zur MühlenSource :
- Clinical endocrinology [ 0300-0664 ] ; 1996.
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Adrenocorticotropic Hormone (secretion), Adult, Corticotropin-Releasing Hormone, Data Interpretation, Statistical, Fenfluramine (blood), Fenfluramine (pharmacology), Humans, Hydrocortisone (blood), Hydrocortisone (secretion), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (secretion), Male, Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (secretion), Serotonin Uptake Inhibitors (blood), Serotonin Uptake Inhibitors (pharmacology).
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Fenfluramine, Hydrocortisone, Serotonin Uptake Inhibitors.
- chemical , pharmacology : Fenfluramine, Serotonin Uptake Inhibitors.
- chemical , secretion : Adrenocorticotropic Hormone, Hydrocortisone.
- drug effects : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- secretion : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Adult, Corticotropin-Releasing Hormone, Data Interpretation, Statistical, Humans, Male.
Abstract
The central serotoninergic system is known to modulate the activity of the hypothalamic-pituitary-adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic-pituitary-adrenal axis in healthy controls.
PubMed: 8796137
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pubmed:8796137Le document en format XML
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<series><title level="j">Clinical endocrinology</title>
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<term>Corticotropin-Releasing Hormone</term>
<term>Data Interpretation, Statistical</term>
<term>Fenfluramine (blood)</term>
<term>Fenfluramine (pharmacology)</term>
<term>Humans</term>
<term>Hydrocortisone (blood)</term>
<term>Hydrocortisone (secretion)</term>
<term>Hypothalamo-Hypophyseal System (drug effects)</term>
<term>Hypothalamo-Hypophyseal System (secretion)</term>
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<term>Serotonin Uptake Inhibitors (blood)</term>
<term>Serotonin Uptake Inhibitors (pharmacology)</term>
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<term>Hydrocortisone</term>
<term>Serotonin Uptake Inhibitors</term>
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<front><div type="abstract" xml:lang="en">The central serotoninergic system is known to modulate the activity of the hypothalamic-pituitary-adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic-pituitary-adrenal axis in healthy controls.</div>
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