Effect of fenfluramine on episodic ACTH and cortisol secretion.
Identifieur interne : 000B17 ( Ncbi/Merge ); précédent : 000B16; suivant : 000B18Effect of fenfluramine on episodic ACTH and cortisol secretion.
Auteurs : T H Schürmeyer [Allemagne] ; G. Brademann ; A. Von Zur MühlenSource :
- Clinical endocrinology [ 0300-0664 ] ; 1996.
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Adrenocorticotropic Hormone (secretion), Adult, Corticotropin-Releasing Hormone, Data Interpretation, Statistical, Fenfluramine (blood), Fenfluramine (pharmacology), Humans, Hydrocortisone (blood), Hydrocortisone (secretion), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (secretion), Male, Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (secretion), Serotonin Uptake Inhibitors (blood), Serotonin Uptake Inhibitors (pharmacology).
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Fenfluramine, Hydrocortisone, Serotonin Uptake Inhibitors.
- chemical , pharmacology : Fenfluramine, Serotonin Uptake Inhibitors.
- chemical , secretion : Adrenocorticotropic Hormone, Hydrocortisone.
- drug effects : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- secretion : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Adult, Corticotropin-Releasing Hormone, Data Interpretation, Statistical, Humans, Male.
Abstract
The central serotoninergic system is known to modulate the activity of the hypothalamic-pituitary-adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic-pituitary-adrenal axis in healthy controls.
PubMed: 8796137
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of fenfluramine on episodic ACTH and cortisol secretion.</title><author><name sortKey="Schurmeyer, T H" sort="Schurmeyer, T H" uniqKey="Schurmeyer T" first="T H" last="Schürmeyer">T H Schürmeyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology and Metabolism, The University, Trier, FR Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Endocrinology and Metabolism, The University, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Brademann, G" sort="Brademann, G" uniqKey="Brademann G" first="G" last="Brademann">G. Brademann</name></author><author><name sortKey="Von Zur Muhlen, A" sort="Von Zur Muhlen, A" uniqKey="Von Zur Muhlen A" first="A" last="Von Zur Mühlen">A. Von Zur Mühlen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8796137</idno><idno type="pmid">8796137</idno><idno type="wicri:Area/PubMed/Corpus">000958</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000958</idno><idno type="wicri:Area/PubMed/Curation">000958</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000958</idno><idno type="wicri:Area/PubMed/Checkpoint">000958</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000958</idno><idno type="wicri:Area/Ncbi/Merge">000B17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of fenfluramine on episodic ACTH and cortisol secretion.</title><author><name sortKey="Schurmeyer, T H" sort="Schurmeyer, T H" uniqKey="Schurmeyer T" first="T H" last="Schürmeyer">T H Schürmeyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Endocrinology and Metabolism, The University, Trier, FR Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Endocrinology and Metabolism, The University, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Brademann, G" sort="Brademann, G" uniqKey="Brademann G" first="G" last="Brademann">G. Brademann</name></author><author><name sortKey="Von Zur Muhlen, A" sort="Von Zur Muhlen, A" uniqKey="Von Zur Muhlen A" first="A" last="Von Zur Mühlen">A. Von Zur Mühlen</name></author></analytic><series><title level="j">Clinical endocrinology</title><idno type="ISSN">0300-0664</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term><term>Adrenocorticotropic Hormone (secretion)</term><term>Adult</term><term>Corticotropin-Releasing Hormone</term><term>Data Interpretation, Statistical</term><term>Fenfluramine (blood)</term><term>Fenfluramine (pharmacology)</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Hydrocortisone (secretion)</term><term>Hypothalamo-Hypophyseal System (drug effects)</term><term>Hypothalamo-Hypophyseal System (secretion)</term><term>Male</term><term>Pituitary-Adrenal System (drug effects)</term><term>Pituitary-Adrenal System (secretion)</term><term>Serotonin Uptake Inhibitors (blood)</term><term>Serotonin Uptake Inhibitors (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Fenfluramine</term><term>Hydrocortisone</term><term>Serotonin Uptake Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fenfluramine</term><term>Serotonin Uptake Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Corticotropin-Releasing Hormone</term><term>Data Interpretation, Statistical</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The central serotoninergic system is known to modulate the activity of the hypothalamic-pituitary-adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic-pituitary-adrenal axis in healthy controls.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8796137</PMID><DateCreated><Year>1996</Year><Month>10</Month><Day>24</Day></DateCreated><DateCompleted><Year>1996</Year><Month>10</Month><Day>24</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0300-0664</ISSN><JournalIssue CitedMedium="Print"><Volume>45</Volume><Issue>1</Issue><PubDate><Year>1996</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Clinical endocrinology</Title><ISOAbbreviation>Clin. Endocrinol. (Oxf)</ISOAbbreviation></Journal><ArticleTitle>Effect of fenfluramine on episodic ACTH and cortisol secretion.</ArticleTitle><Pagination><MedlinePgn>39-45</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The central serotoninergic system is known to modulate the activity of the hypothalamic-pituitary-adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic-pituitary-adrenal axis in healthy controls.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Episodic secretion of ACTH and cortisol was investigated in 6 healthy volunteers under basal conditions and again during treatment with 20 and 60 mg fenfluramine given orally every 8 hours. On all occasions blood samples were obtained at 10-minute intervals for 24 hours and the mode of hormone secretion was analysed by three different methods (PULSAR, CLUSTER, DESADE). In addition ACTH and cortisol responses to CRH were tested at the end of the sampling period.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At the lower dose fenfluramine had no effect on ACTH and cortisol secretion. At the higher dose a significant increase of mean plasma ACTH (+85%) and cortisol (+129%) levels as well as of urinary free cortisol secretion (+44%) was observed. Fenfluramine did not modulate the frequency, but increased the amplitudes of ACTH and cortisol secretory episodes. ACTH and cortisol responses to CRH injection remained unchanged. Maximum plasma levels of d-fenfluramine and d-norfenfluramine were documented 2-4 hours after the ingestion of the drug.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Fenfluramine stimulates the activity of the hypothalamic-pituitary-adrenal axis at a suprapituitary level by modulating the amplitude of ACTH and cortisol secretory bursts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schürmeyer</LastName><ForeName>T H</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>Department of Endocrinology and Metabolism, The University, Trier, FR Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brademann</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>von zur Mühlen</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D018848">Controlled Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Clin Endocrinol (Oxf)</MedlineTA><NlmUniqueID>0346653</NlmUniqueID><ISSNLinking>0300-0664</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017367">Serotonin Uptake Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>2DS058H2CF</RegistryNumber><NameOfSubstance UI="D005277">Fenfluramine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-60-2</RegistryNumber><NameOfSubstance UI="D000324">Adrenocorticotropic Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>9015-71-8</RegistryNumber><NameOfSubstance UI="D003346">Corticotropin-Releasing Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000324" MajorTopicYN="N">Adrenocorticotropic Hormone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000557" MajorTopicYN="Y">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003346" MajorTopicYN="N">Corticotropin-Releasing Hormone</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003627" MajorTopicYN="N">Data Interpretation, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005277" MajorTopicYN="N">Fenfluramine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000557" MajorTopicYN="Y">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017367" MajorTopicYN="N">Serotonin Uptake Inhibitors</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8796137</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Brademann, G" sort="Brademann, G" uniqKey="Brademann G" first="G" last="Brademann">G. Brademann</name><name sortKey="Von Zur Muhlen, A" sort="Von Zur Muhlen, A" uniqKey="Von Zur Muhlen A" first="A" last="Von Zur Mühlen">A. Von Zur Mühlen</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Schurmeyer, T H" sort="Schurmeyer, T H" uniqKey="Schurmeyer T" first="T H" last="Schürmeyer">T H Schürmeyer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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