UnivTrevesV1, Istex, Corpus, bibRecord, 000A71

Effect of fenfluramine on episodic ACTH and cortisol secretion

Identifieur interne : 000A71 ( Istex/Corpus ); précédent : 000A70; suivant : 000A72

Effect of fenfluramine on episodic ACTH and cortisol secretion

Auteurs : Thomas H. Schürmeyer ; Götz Brademann ; Alexander Von Zur Mühlen

Source :

Clinical Endocrinology [ 0300-0664 ] ; 1996-07.

RBID : ISTEX:81AC0B22444DABEF801A60ED574537C634D6792C

Abstract

OBJECTIVE The central serotoninergic system is known to modulate the activity of the hypothalamic‐pituitary‐adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic‐pituitary‐adrenal axis in healthy controls.

Url:

https://api.istex.fr/document/81AC0B22444DABEF801A60ED574537C634D6792C/fulltext/pdf

DOI: 10.1111/j.1365-2265.1996.tb02058.x

Links to Exploration step

ISTEX:81AC0B22444DABEF801A60ED574537C634D6792C

Le document en format XML

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<refBibs><json:item><author><json:item><name>G.M. Asnis</name>
</json:item>
<json:item><name>J. Eisenberg</name>
</json:item>
<json:item><name>H.M. van Praag</name>
</json:item>
<json:item><name>C.Z. Lemus</name>
</json:item>
<json:item><name>J.M. Harkavy Friedman</name>
</json:item>
<json:item><name>A.H. Miller</name>
</json:item>
</author>
<host><volume>24</volume>
<pages><last>120</last>
<first>117</first>
</pages>
<author></author>
<title>Biological Psychiatry</title>
</host>
<title>The neuroendocrine response to funfluramine in depressives and normal controls</title>
</json:item>
<json:item><author><json:item><name>A.H. Beckett</name>
</json:item>
<json:item><name>J.A. Salmon</name>
</json:item>
</author>
<host><volume>24</volume>
<pages><last>114</last>
<first>108</first>
</pages>
<author></author>
<title>Journal of Pharmacy and Pharmacology</title>
</host>
<title>Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man</title>
</json:item>
<json:item><author><json:item><name>G.P.F. Bernini</name>
</json:item>
<json:item><name>G.F. Argenio</name>
</json:item>
<json:item><name>M.S. Vivaldi</name>
</json:item>
<json:item><name>R. Birindelli</name>
</json:item>
<json:item><name>F. Franchi</name>
</json:item>
</author>
<host><volume>41</volume>
<pages><last>21</last>
<first>17</first>
</pages>
<author></author>
<title>Metabolism</title>
</host>
<title>Serotoninergic receptor activation by dextrofenfluramine enhances the blunted pituitary‐adrenal responsiveness to corticotropin‐releasing hormone in obese subjects</title>
</json:item>
<json:item><author><json:item><name>R.B. Bruce</name>
</json:item>
<json:item><name>W.R. Maynard</name>
</json:item>
</author>
<host><volume>57</volume>
<pages><last>1176</last>
<first>1173</first>
</pages>
<author></author>
<title>Journal of Pharmaceutical Sciences</title>
</host>
<title>Fenfluramine metabolism</title>
</json:item>
<json:item><author><json:item><name>J.C. Buckingham</name>
</json:item>
<json:item><name>J.R. Hodges</name>
</json:item>
</author>
<host><volume>290</volume>
<pages><last>431</last>
<first>421</first>
</pages>
<author></author>
<title>Journal of Physiology (London)</title>
</host>
<title>Hypothalamic receptors involved in the secretion of corticotrophin releasing factor</title>
</json:item>
<json:item><author><json:item><name>S. Caccia</name>
</json:item>
<json:item><name>I. Conforti</name>
</json:item>
<json:item><name>J. Duchier</name>
</json:item>
<json:item><name>S. Garattini</name>
</json:item>
</author>
<host><volume>29</volume>
<pages><last>224</last>
<first>221</first>
</pages>
<author></author>
<title>European Journal of Clinical Pharmacology</title>
</host>
<title>Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d‐ and d, l‐fenfluramine for 15 days</title>
</json:item>
<json:item><author><json:item><name>T.N. Chase</name>
</json:item>
<json:item><name>I. Shoulson</name>
</json:item>
</author>
<host><volume>51</volume>
<pages><last>109</last>
<first>105</first>
</pages>
<issue>Suppl. 1</issue>
<author></author>
<title>Postgraduate Medical Journal</title>
</host>
<title>Behavioral and biochemical effects of fenfluramine in patients with neurologic disease</title>
</json:item>
<json:item><author><json:item><name>E. Davies</name>
</json:item>
<json:item><name>S. Rossiter</name>
</json:item>
</author>
<host><volume>42</volume>
<pages><last>36</last>
<first>29</first>
</pages>
<author></author>
<title>Journal of Steroid Biochemistry and Molecular Biology</title>
</host>
<title>Serotoninergic stimulation of aldosterone secretion in vivo: role of the hypothalamopituitary adrenal axis</title>
</json:item>
<json:item><author><json:item><name>C. Fornal</name>
</json:item>
<json:item><name>M. Radulovacki</name>
</json:item>
</author>
<host><volume>225</volume>
<pages><last>681</last>
<first>675</first>
</pages>
<author></author>
<title>Journal of Pharmacology and Experimental Therapeutics</title>
</host>
<title>Sleep suppressant action of fenfluramine in rats. Evidence against the involvement of a presynaptic serotonergic mechanism</title>
</json:item>
<json:item><author><json:item><name>R.W. Fuller</name>
</json:item>
</author>
<host><volume>13</volume>
<pages><last>270</last>
<first>250</first>
</pages>
<author></author>
<title>Frontiers in Neuroendocrinology</title>
</host>
<title>The involvement of serotonin in regulation of pituitary‐adrenocortical function</title>
</json:item>
<json:item><author><json:item><name>S. Garatti</name>
</json:item>
<json:item><name>T. Mennini</name>
</json:item>
<json:item><name>R. Samanin</name>
</json:item>
</author>
<host><volume>499</volume>
<pages><last>166</last>
<first>156</first>
</pages>
<author></author>
<title>Annals of the New York Academy of Sciences</title>
</host>
<title>From fenfluramine racemate to d‐fenfluramine. Specificity and potency of the effects on the serotoninergic system and food intake</title>
</json:item>
<json:item><author><json:item><name>C.R. Gardner</name>
</json:item>
</author>
<host><pages><last>325</last>
<first>281</first>
</pages>
<author></author>
<title>Neuropharmacology of Serotonin</title>
</host>
<title>Pharmacological studies of the role of serotonin in animal models of anxiety</title>
</json:item>
<json:item><author><json:item><name>S.E. Gartside</name>
</json:item>
<json:item><name>P.M. Ellis</name>
</json:item>
<json:item><name>T. Sharp</name>
</json:item>
<json:item><name>P.J. Cowen</name>
</json:item>
</author>
<host><volume>221</volume>
<pages><last>33</last>
<first>27</first>
</pages>
<author></author>
<title>European Journal of Pharmacology</title>
</host>
<title>Selective 5‐HT1 A and 5‐HT2 receptor‐mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments</title>
</json:item>
<json:item><author><json:item><name>P.W. Gold</name>
</json:item>
<json:item><name>F.K. Goodwin</name>
</json:item>
<json:item><name>G.P. Chrousos</name>
</json:item>
</author>
<host><volume>319</volume>
<pages><last>354</last>
<first>348</first>
</pages>
<author></author>
<title>New England Journal of Medicine</title>
</host>
<title>Clinical and biochemical manifestation of depression‐Relation to the neurobiology of stress</title>
</json:item>
<json:item><author><json:item><name>A. Grossman</name>
</json:item>
<json:item><name>A. Costa</name>
</json:item>
</author>
<host><volume>8</volume>
<pages><last>334</last>
<first>325</first>
</pages>
<author></author>
<title>Functional Neurology</title>
</host>
<title>The regulation of hypothalamic CRH: impact of in vitro studies on the central control of the stress response</title>
</json:item>
<json:item><author><json:item><name>V. Guillaume</name>
</json:item>
<json:item><name>M. Grino</name>
</json:item>
<json:item><name>D. Jevoza</name>
</json:item>
<json:item><name>F. Bondouresque</name>
</json:item>
<json:item><name>C. Oliver</name>
</json:item>
<json:item><name>B. Guardiola‐Lemaitre</name>
</json:item>
<json:item><name>C. Nathan</name>
</json:item>
</author>
<host><volume>13</volume>
<pages><last>89</last>
<first>87</first>
</pages>
<author></author>
<title>International Journal of Obesity</title>
</host>
<title>Effect of acute or chronic administration of d‐fenfluramine on the hypothalamo‐hypophysoadrenal axis in the rat</title>
</json:item>
<json:item><author><json:item><name>H. Hauser</name>
</json:item>
<json:item><name>T.H. Schürmeyer</name>
</json:item>
<json:item><name>G. Brabant</name>
</json:item>
<json:item><name>B. Rathke</name>
</json:item>
<json:item><name>A. VON zur Mühlen</name>
</json:item>
</author>
<host><volume>120</volume>
<pages><last>101</last>
<first>100</first>
</pages>
<issue>Suppl. 1</issue>
<author></author>
<title>Acta Endocrinologica</title>
</host>
<title>Effect of sleep and sleep deprivation on ACTH‐ and cortisol secretion patterns</title>
</json:item>
<json:item><author><json:item><name>J.P. Heybach</name>
</json:item>
<json:item><name>J. Vernikos‐Danellis</name>
</json:item>
</author>
<host><volume>21</volume>
<pages><last>25</last>
<first>19</first>
</pages>
<author></author>
<title>Proceedings of the Western Pharmacological Society</title>
</host>
<title>Effect of fenfluramine administration on activity of the pituitary‐adrenal system in the rat</title>
</json:item>
<json:item><author><json:item><name>M.C. Holmes</name>
</json:item>
<json:item><name>G. Di Renzo</name>
</json:item>
<json:item><name>U. Beckford</name>
</json:item>
<json:item><name>B. Gillham</name>
</json:item>
<json:item><name>M.T. Jones</name>
</json:item>
</author>
<host><volume>93</volume>
<pages><last>160</last>
<first>151</first>
</pages>
<author></author>
<title>Journal of Endocrinology</title>
</host>
<title>Role of serotonin in the control of secretion of corticotropin releasing factor</title>
</json:item>
<json:item><author><json:item><name>H. Imura</name>
</json:item>
<json:item><name>Y. Nakay</name>
</json:item>
<json:item><name>T. Yoshimi</name>
</json:item>
</author>
<host><volume>36</volume>
<pages><last>209</last>
<first>204</first>
</pages>
<author></author>
<title>Journal of Clinical Endocrinology and Metabolism</title>
</host>
<title>Effect of 5‐hydroxy‐tryptophan on growth hormone and ACTH release in man</title>
</json:item>
<json:item><author><json:item><name>J.A. Innes</name>
</json:item>
<json:item><name>M.L. Watson</name>
</json:item>
<json:item><name>M.J. Ford</name>
</json:item>
<json:item><name>J.F. Monro</name>
</json:item>
<json:item><name>M.E. Stoddart</name>
</json:item>
<json:item><name>D.B. Campbell</name>
</json:item>
</author>
<host><volume>2</volume>
<pages><last>1325</last>
<first>1311</first>
</pages>
<author></author>
<title>British Medical Journal</title>
</host>
<title>Plasma fenfluramine levels, weight loss, and side effects</title>
</json:item>
<json:item><author><json:item><name>A. Iranmanesh</name>
</json:item>
<json:item><name>G. Lizarralde</name>
</json:item>
<json:item><name>ML. Johnson</name>
</json:item>
<json:item><name>J.D. Veldhuis</name>
</json:item>
</author>
<host><volume>68</volume>
<pages><last>1026</last>
<first>1019</first>
</pages>
<author></author>
<title>Journal of Clinical Endocrinology & Metabolism</title>
</host>
<title>Circadian, ultradian, and episodic release of beta‐endorphin in men, and its temporal coupling with cortisol</title>
</json:item>
<json:item><author><json:item><name>G. Ixart</name>
</json:item>
<json:item><name>A. Szafarczyk</name>
</json:item>
<json:item><name>L. Belugou</name>
</json:item>
<json:item><name>I. Assenmacher</name>
</json:item>
</author>
<host><volume>72</volume>
<pages><last>120</last>
<first>113</first>
</pages>
<author></author>
<title>Journal of Endocrinology</title>
</host>
<title>Temporal relationships between the diurnal rhythm of hypothalamic corticotrophin releasing factor, pituitary corticotrophin, and plasma corticosterone in the rat</title>
</json:item>
<json:item><author><json:item><name>D.T. Krieger</name>
</json:item>
</author>
<host><volume>6</volume>
<pages><last>791</last>
<first>785</first>
</pages>
<author></author>
<title>Journal of Steroid Biochemistry</title>
</host>
<title>Rhythm of ACTH and corticosteroid secretion in health and disease, and their experimental modification</title>
</json:item>
<json:item><author><json:item><name>D.T. Krieger</name>
</json:item>
<json:item><name>F. Rizzo</name>
</json:item>
</author>
<host><pages><last>1707</last>
<first>1703</first>
</pages>
<author></author>
<title>Journal of Physiology (London)</title>
</host>
<title>Serotonin mediation of circadian periodicity of plasma 17‐hydroxycorticosteroids</title>
</json:item>
<json:item><author><json:item><name>M.A. Lee</name>
</json:item>
<json:item><name>H.Y. Meltzer</name>
</json:item>
</author>
<host><volume>30</volume>
<pages><last>1030</last>
<first>1017</first>
</pages>
<author></author>
<title>Biological Psychiatry</title>
</host>
<title>Neuroendocrine responses to serotonergic agents in alcoholics</title>
</json:item>
<json:item><author><json:item><name>M.A. Lee</name>
</json:item>
<json:item><name>J.F. Nash</name>
</json:item>
<json:item><name>M. Barnes</name>
</json:item>
<json:item><name>H.Y. Meltzer</name>
</json:item>
</author>
<host><volume>103</volume>
<pages><last>264</last>
<first>258</first>
</pages>
<author></author>
<title>Psychopharmacology</title>
</host>
<title>Inhibitory effect of ritanserin on the 5‐hydroxytryptophan‐mediated cortisol, ACTH and prolactin secretion in humans</title>
</json:item>
<json:item><author><json:item><name>K.P.O. Lesch</name>
</json:item>
<json:item><name>M. Wiesmann</name>
</json:item>
<json:item><name>A. Hoh</name>
</json:item>
<json:item><name>T. Müller</name>
</json:item>
<json:item><name>J. Disselkamp‐Tietze</name>
</json:item>
<json:item><name>M. Osterheider</name>
</json:item>
<json:item><name>HM. Schulte</name>
</json:item>
</author>
<host><volume>106</volume>
<pages><last>117</last>
<first>111</first>
</pages>
<author></author>
<title>Psychopharmacology (Berlin)</title>
</host>
<title>5‐HT1 A receptor‐effector system responsivity in panic disorder</title>
</json:item>
<json:item><author><json:item><name>A.D. Levy</name>
</json:item>
<json:item><name>Q. Li</name>
</json:item>
<json:item><name>P.A. Rittenhouse</name>
</json:item>
<json:item><name>L.D. Van de Kar</name>
</json:item>
</author>
<host><volume>58</volume>
<pages><last>70</last>
<first>65</first>
</pages>
<author></author>
<title>Neuroendocrinology</title>
</host>
<title>Investigation of the role of 5‐HT3 receptors in the secretion of prolactin, ACTH and renin</title>
</json:item>
<json:item><author><json:item><name>S.A. Lewis</name>
</json:item>
<json:item><name>I. Oswald</name>
</json:item>
<json:item><name>D.L.F. Dunleavy</name>
</json:item>
</author>
<host><volume>3</volume>
<pages><last>70</last>
<first>67</first>
</pages>
<author></author>
<title>British Medical Journal</title>
</host>
<title>Chronic fenfluramine administration: some cerebral effects</title>
</json:item>
<json:item><author><json:item><name>J.F. McElroy</name>
</json:item>
<json:item><name>J.M. Miller</name>
</json:item>
<json:item><name>J.S. Meyer</name>
</json:item>
</author>
<host><volume>228</volume>
<pages><last>599</last>
<first>593</first>
</pages>
<author></author>
<title>Journal of Pharmacology and Experimental Therapeutics</title>
</host>
<title>Fenfluramine, p‐chloroamphetamine and p‐flouroamphetamine stimulation of pituitary‐ adrenocortical activity in rat: evidence of differences in site and mechanism of action</title>
</json:item>
<json:item><author><json:item><name>G.R. Merriam</name>
</json:item>
<json:item><name>K.W. Wachter</name>
</json:item>
</author>
<host><volume>243</volume>
<pages><last>318</last>
<first>310</first>
</pages>
<author></author>
<title>American Journal of Physiology</title>
</host>
<title>Algorithms for the study of episodic hormone secretion</title>
</json:item>
<json:item><author><json:item><name>D.L. Murphy</name>
</json:item>
<json:item><name>I.C. Campbell</name>
</json:item>
<json:item><name>J.L. Costa</name>
</json:item>
</author>
<host><volume>2</volume>
<pages><last>31</last>
<first>5</first>
</pages>
<author></author>
<title>Progress in Neuropsychopharmacology</title>
</host>
<title>The brain serotonergic system in the affective disorders</title>
</json:item>
<json:item><author><json:item><name>D.L. Murphy</name>
</json:item>
<json:item><name>E.A. Mueller</name>
</json:item>
<json:item><name>N.A. Garrick</name>
</json:item>
<json:item><name>C.S. Aulakh</name>
</json:item>
</author>
<host><volume>47</volume>
<pages><last>13</last>
<first>9</first>
</pages>
<author></author>
<title>Journal of Clinical Psychiatry</title>
</host>
<title>Use of serotonergic agents in the clinical assessment of central serotonin function</title>
</json:item>
<json:item><author><json:item><name>E.V. Naumenko</name>
</json:item>
</author>
<host><volume>5</volume>
<pages><last>88</last>
<first>81</first>
</pages>
<author></author>
<title>Neuroendocrinology</title>
</host>
<title>Effect of local injection of 5‐hydroxytryptamine into rhinencephalic and mesencephalic structures on pituitary‐adrenal function in guinea pigs</title>
</json:item>
<json:item><author><json:item><name>W.E. Nicholson</name>
</json:item>
<json:item><name>D.R. Davis</name>
</json:item>
<json:item><name>B.J. Sherrell</name>
</json:item>
<json:item><name>D.N. Orth</name>
</json:item>
</author>
<host><volume>30</volume>
<pages><last>265</last>
<first>259</first>
</pages>
<author></author>
<title>Clinical Chemistry</title>
</host>
<title>Rapid radioimmunoassay for corticotropin in unextracted human plasma</title>
</json:item>
<json:item><author><json:item><name>K.E. Oerter</name>
</json:item>
<json:item><name>V. Guardabasso</name>
</json:item>
<json:item><name>D. Rodbard</name>
</json:item>
</author>
<host><volume>19</volume>
<pages><last>191</last>
<first>170</first>
</pages>
<author></author>
<title>Computers and Biomededical Research</title>
</host>
<title>Detection and characterization of peaks and estimation of instantaneous secretory rates for episodic pulsatile hormone secretion</title>
</json:item>
<json:item><author><json:item><name>M.J. Owens</name>
</json:item>
<json:item><name>D.L. Knight</name>
</json:item>
<json:item><name>J.C. Ritchie</name>
</json:item>
<json:item><name>C.B. Nemeroff</name>
</json:item>
</author>
<host><volume>256</volume>
<pages><last>800</last>
<first>795</first>
</pages>
<author></author>
<title>Journal of Pharmacology and Experimental Therapeutics</title>
</host>
<title>The 5‐hydroxytryptamine2 agonist, 1‐(2,5‐dimethoxy‐4‐bromophenyl)‐2‐aminopropane stimulates the hypothalamic‐pituitary‐adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration</title>
</json:item>
<json:item><author><json:item><name>H. Pijl</name>
</json:item>
<json:item><name>H.P. Koppeschaar</name>
</json:item>
<json:item><name>F.L. Willekens</name>
</json:item>
<json:item><name>M. Frolich</name>
</json:item>
<json:item><name>A.E. Meinders</name>
</json:item>
</author>
<host><volume>128</volume>
<pages><last>324</last>
<first>319</first>
</pages>
<author></author>
<title>Acta Endocrinologica</title>
</host>
<title>The influence of serotonergic neurotransmission on pituitary hormone release in obese and non‐obese females</title>
</json:item>
<json:item><author><json:item><name>M.J. Raleigh</name>
</json:item>
<json:item><name>G.L. Brammer</name>
</json:item>
<json:item><name>E.R. Ritvo</name>
</json:item>
<json:item><name>E. Geller</name>
</json:item>
<json:item><name>M.T. McGuire</name>
</json:item>
<json:item><name>A. Yuwiler</name>
</json:item>
</author>
<host><volume>90</volume>
<pages><last>508</last>
<first>503</first>
</pages>
<author></author>
<title>Psychopharmacology</title>
</host>
<title>Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys</title>
</json:item>
<json:item><author><json:item><name>U. Ranft</name>
</json:item>
<json:item><name>K. Prank</name>
</json:item>
<json:item><name>G. Brabant</name>
</json:item>
</author>
<host><volume>177</volume>
<pages><last>80</last>
<first>79</first>
</pages>
<issue>Suppl. 287</issue>
<author></author>
<title>Acta Endocrinologica</title>
</host>
<title>Detection of episodic secretion activity by discrete deconvolution (DESADE) ‐ a new method for the analysis of episodic hormone secretion</title>
</json:item>
<json:item><author><json:item><name>R.P. Richards</name>
</json:item>
<json:item><name>B.H. Gordon</name>
</json:item>
<json:item><name>R.M.J. Ings</name>
</json:item>
<json:item><name>D.B. Campbell</name>
</json:item>
<json:item><name>L.J. King</name>
</json:item>
</author>
<host><volume>19</volume>
<pages><last>553</last>
<first>547</first>
</pages>
<author></author>
<title>Xenobiotica</title>
</host>
<title>The measurement of d‐fenfluramine and its metabolite, d‐norfenfluramine in plasma and urine with an application of the method to pharmacokinetic studies</title>
</json:item>
<json:item><author><json:item><name>M.H.T. Roberts</name>
</json:item>
</author>
<host><volume>23</volume>
<pages><last>1536</last>
<first>1529</first>
</pages>
<author></author>
<title>Neuropharmacology</title>
</host>
<title>Hydroxytryptamine and antinociception</title>
</json:item>
<json:item><author><json:item><name>N.E. Rowland</name>
</json:item>
<json:item><name>J. Carlton</name>
</json:item>
</author>
<host><volume>27</volume>
<pages><last>62</last>
<first>13</first>
</pages>
<author></author>
<title>Progress in Neurobiology</title>
</host>
<title>Neurobiology of an anorectic drug: fenfluramine</title>
</json:item>
<json:item><author><json:item><name>U. Scapagnini</name>
</json:item>
<json:item><name>G.P. Moberg</name>
</json:item>
<json:item><name>G.R. Van Loon</name>
</json:item>
<json:item><name>J. de Groot</name>
</json:item>
<json:item><name>W.F. Ganong</name>
</json:item>
</author>
<host><volume>7</volume>
<pages><last>96</last>
<first>90</first>
</pages>
<author></author>
<title>Neuroendocrinology</title>
</host>
<title>Relation of brain 5‐hydroxytryptamine content to the diurnal variation in plasma corticosterone in the rat</title>
</json:item>
<json:item><author><json:item><name>T.H. Schürmeyer</name>
</json:item>
<json:item><name>G. Brabant</name>
</json:item>
<json:item><name>A. VON zur Muhlen</name>
</json:item>
</author>
<host><pages><last>113</last>
<first>105</first>
</pages>
<author></author>
<title>ACTH, Cushing's Syndrome and other Hypercortisolemic States</title>
</host>
<title>Evidence, that the hypothesis on a hypothalamic origin of Cushings disease is not an outdated concept</title>
</json:item>
<json:item><author><json:item><name>T.H. Schürmeyer</name>
</json:item>
<json:item><name>G. Brademann</name>
</json:item>
<json:item><name>A. VON zur Muhlen</name>
</json:item>
</author>
<host><volume>26</volume>
<pages><last>403</last>
<first>397</first>
</pages>
<author></author>
<title>European Journal of Clinical Investigation</title>
</host>
<title>Effect of cyproheptadine on episodic ACTH and cortisol secretion</title>
</json:item>
<json:item><author><json:item><name>O. Serri</name>
</json:item>
<json:item><name>E. Rasio</name>
</json:item>
</author>
<host><volume>6b5</volume>
<pages><last>2453</last>
<first>2449</first>
</pages>
<author></author>
<title>Canadian Journal of Physiology and Pharmacology</title>
</host>
<title>The effect of d‐fenfluramine on anterior pituitary hormone release in the rat: in vivo and in vitro studies</title>
</json:item>
<json:item><author><json:item><name>J.A. Steiner</name>
</json:item>
<json:item><name>D.G. Grahame‐Smith</name>
</json:item>
</author>
<host><volume>71</volume>
<pages><last>217</last>
<first>213</first>
</pages>
<author></author>
<title>Psychopharmacology</title>
</host>
<title>Central pharmacological control of corticosterone metion in the intact rat. Demonstration of cholinergic and serotoninergic facilitory and α‐adrenergic inhibitory mechanisms</title>
</json:item>
<json:item><author><json:item><name>W.R. Sulaiman</name>
</json:item>
<json:item><name>R.H. Johnson</name>
</json:item>
<json:item><name>M.J. Rennie</name>
</json:item>
</author>
<host><volume>51</volume>
<pages><last>131</last>
<first>125</first>
</pages>
<author></author>
<title>Postgraduate Medical Journal</title>
</host>
<title>Hormonal and metabolic studies of the action of fenfluramine in normal man, obesity, acromegaly and diabetes mellitus</title>
</json:item>
<json:item><author><json:item><name>A. Szafarczyk</name>
</json:item>
<json:item><name>G. Alonso</name>
</json:item>
<json:item><name>G. Ixart</name>
</json:item>
<json:item><name>F. Malaval</name>
</json:item>
<json:item><name>J. Nouguier‐Soule</name>
</json:item>
<json:item><name>I. Assenmacher</name>
</json:item>
</author>
<host><volume>239</volume>
<pages><last>489</last>
<first>482</first>
</pages>
<author></author>
<title>American Journal of Physiology</title>
</host>
<title>Serotonergic system and circadian rhythms of ACTH and corticosterone in rats</title>
</json:item>
<json:item><author><json:item><name>A. Tagliamonte</name>
</json:item>
<json:item><name>G. Biggio</name>
</json:item>
<json:item><name>L. Targiu</name>
</json:item>
<json:item><name>G.L. Gessa</name>
</json:item>
</author>
<host><volume>12</volume>
<pages><last>287</last>
<first>277</first>
</pages>
<author></author>
<title>Life Sciences</title>
</host>
<title>Free tryptophan in serum controls brain tryptophan level and serotonin synthesis</title>
</json:item>
<json:item><author><json:item><name>C.J. Thompson</name>
</json:item>
<json:item><name>I.R. Jones</name>
</json:item>
<json:item><name>M. Walker</name>
</json:item>
<json:item><name>P.H. Baylis</name>
</json:item>
<json:item><name>P. Kendall‐Taylor</name>
</json:item>
</author>
<host><volume>36</volume>
<pages><last>240</last>
<first>235</first>
</pages>
<author></author>
<title>ClinicaI Endocrinology</title>
</host>
<title>The effects of the specific serotonin antagonist ICI, 169, 369 on the pituitary hormone response to insulin‐induced hypoglycaemia in humans</title>
</json:item>
<json:item><author><json:item><name>J.D. Veldhuis</name>
</json:item>
<json:item><name>A. Iranmanesh</name>
</json:item>
<json:item><name>M.L. Johnson</name>
</json:item>
<json:item><name>G. Lizarralde</name>
</json:item>
</author>
<host><volume>71</volume>
<pages><last>463</last>
<first>452</first>
</pages>
<author></author>
<title>Journal of Clinical Endocrinology and Metabolism</title>
</host>
<title>Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man</title>
</json:item>
<json:item><author><json:item><name>J.D. Veldhuis</name>
</json:item>
<json:item><name>M.L. Johnson</name>
</json:item>
</author>
<host><volume>13</volume>
<pages><last>493</last>
<first>486</first>
</pages>
<author></author>
<title>American Journal of Physiology</title>
</host>
<title>Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection</title>
</json:item>
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<affiliation>Department of Endocrinology and Metabolism at the University, FPP, D‐54286 Trier</affiliation>
<affiliation>Thomas H. Schürmeyer, Department of Endocrinology and Metabolism at the University, FPP, D‐54286 Trier, FR Germany.</affiliation>
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<author xml:id="author-2"><persName><forename type="first">Götz</forename>
<surname>Brademann</surname>
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<affiliation>Department of Clinical Endocrinology, Medizinische Hochschule, D‐30625 Hannover, FR Germany</affiliation>
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<author xml:id="author-3"><persName><forename type="first">Alexander</forename>
<surname>von zur Mühlen</surname>
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<affiliation>Department of Clinical Endocrinology, Medizinische Hochschule, D‐30625 Hannover, FR Germany</affiliation>
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<abstract><p>OBJECTIVE The central serotoninergic system is known to modulate the activity of the hypothalamic‐pituitary‐adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic‐pituitary‐adrenal axis in healthy controls.</p>
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<abstract><p>DESIGN Episodic secretion of ACTH and cortisol was Investigated in 6 healthy volunteers under basal conditions and again during treatment with 20 and 60 mg fenfluramine given orally every 8 hours. On all occasions blood samples were obtained at 10‐minute Intervals for 24 hours and the mode of hormone secretion was analysed by three different methods (PULSAR, CLUSTER, DESADE). In addition ACTH and cortisol responses to CRH were tested at the end of the sampling period.</p>
</abstract>
<abstract><p>RESULTS At the lower dose fenfluramine had no effect on ACTH and cortisol secretion. At the higher dose a significant increase of mean plasma ACTH (+ 85%) and cortisol (+129%) levels as well as of urinary free cortisol secretion (+44%) was observed. Fenfluramine did not modulate the frequency, but increased the amplitudes of ACTH and cortisol secretory episodes. ACTH and cortisol responses to CRH injection remained unchanged. Maximum plasma levels of d‐fenfluramine and d‐nortenfluramine were documented 2–4 hours after the ingestlon of the drug.</p>
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<abstract><p>CONCLUSION Fenfluramine stimulates the activity of the hypothalamic‐pituitary‐adrenal axis at a suprapituitary level by modulating the amplitude of ACTH and cortisol secretory bursts.</p>
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<affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Clinical Endocrinology, Medizinische Hochschule, D‐30625 Hannover, FR Germany</unparsedAffiliation>
</affiliation>
<affiliation xml:id="a2"><unparsedAffiliation>Department of Endocrinology and Metabolism at the University, FPP, D‐54286 Trier</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title>
<p><b>OBJECTIVE</b>
 The central serotoninergic system is known to modulate the activity of the hypothalamic‐pituitary‐adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic‐pituitary‐adrenal axis in healthy controls.</p>
<p><b>DESIGN</b>
 Episodic secretion of ACTH and cortisol was Investigated in 6 healthy volunteers under basal conditions and again during treatment with 20 and 60 mg fenfluramine given orally every 8 hours. On all occasions blood samples were obtained at 10‐minute Intervals for 24 hours and the mode of hormone secretion was analysed by three different methods (PULSAR, CLUSTER, DESADE). In addition ACTH and cortisol responses to CRH were tested at the end of the sampling period.</p>
<p><b>RESULTS</b>
 At the lower dose fenfluramine had no effect on ACTH and cortisol secretion. At the higher dose a significant increase of mean plasma ACTH (+ 85%) and cortisol (+129%) levels as well as of urinary free cortisol secretion (+44%) was observed. Fenfluramine did not modulate the frequency, but increased the amplitudes of ACTH and cortisol secretory episodes. ACTH and cortisol responses to CRH injection remained unchanged. Maximum plasma levels of <i>d</i>
‐fenfluramine and <i>d</i>
‐nortenfluramine were documented 2–4 hours after the ingestlon of the drug.</p>
<p><b>CONCLUSION</b>
 Fenfluramine stimulates the activity of the hypothalamic‐pituitary‐adrenal axis at a suprapituitary level by modulating the amplitude of ACTH and cortisol secretory bursts.</p>
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<mods version="3.6"><titleInfo lang="en"><title>Effect of fenfluramine on episodic ACTH and cortisol secretion</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of fenfluramine on episodic ACTH and cortisol secretion</title>
</titleInfo>
<name type="personal"><namePart type="given">Thomas H.</namePart>
<namePart type="family">Schürmeyer</namePart>
<affiliation>Department of Endocrinology and Metabolism at the University, FPP, D‐54286 Trier</affiliation>
<affiliation>Thomas H. Schürmeyer, Department of Endocrinology and Metabolism at the University, FPP, D‐54286 Trier, FR Germany.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Götz</namePart>
<namePart type="family">Brademann</namePart>
<affiliation>Department of Clinical Endocrinology, Medizinische Hochschule, D‐30625 Hannover, FR Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Alexander</namePart>
<namePart type="family">von zur Mühlen</namePart>
<affiliation>Department of Clinical Endocrinology, Medizinische Hochschule, D‐30625 Hannover, FR Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<originInfo><publisher>Blackwell Publishing Ltd</publisher>
<place><placeTerm type="text">Oxford, UK</placeTerm>
</place>
<dateIssued encoding="w3cdtf">1996-07</dateIssued>
<edition>Received 16 November 1995; returned for revision 31 January 1996; finally revised 13 March 1996; accepted 11 April 1996</edition>
<copyrightDate encoding="w3cdtf">1996</copyrightDate>
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<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<extent unit="references">55</extent>
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<abstract>OBJECTIVE The central serotoninergic system is known to modulate the activity of the hypothalamic‐pituitary‐adrenal axis, but the effect of fenfluramine, a serotonin reuptake inhibitor, on ACTH and cortisol secretion is not well understood. We have therefore evaluated its effects on the hypothalamic‐pituitary‐adrenal axis in healthy controls.</abstract>
<abstract>DESIGN Episodic secretion of ACTH and cortisol was Investigated in 6 healthy volunteers under basal conditions and again during treatment with 20 and 60 mg fenfluramine given orally every 8 hours. On all occasions blood samples were obtained at 10‐minute Intervals for 24 hours and the mode of hormone secretion was analysed by three different methods (PULSAR, CLUSTER, DESADE). In addition ACTH and cortisol responses to CRH were tested at the end of the sampling period.</abstract>
<abstract>RESULTS At the lower dose fenfluramine had no effect on ACTH and cortisol secretion. At the higher dose a significant increase of mean plasma ACTH (+ 85%) and cortisol (+129%) levels as well as of urinary free cortisol secretion (+44%) was observed. Fenfluramine did not modulate the frequency, but increased the amplitudes of ACTH and cortisol secretory episodes. ACTH and cortisol responses to CRH injection remained unchanged. Maximum plasma levels of d‐fenfluramine and d‐nortenfluramine were documented 2–4 hours after the ingestlon of the drug.</abstract>
<abstract>CONCLUSION Fenfluramine stimulates the activity of the hypothalamic‐pituitary‐adrenal axis at a suprapituitary level by modulating the amplitude of ACTH and cortisol secretory bursts.</abstract>
<relatedItem type="host"><titleInfo><title>Clinical Endocrinology</title>
</titleInfo>
<genre type="journal">journal</genre>
<identifier type="ISSN">0300-0664</identifier>
<identifier type="eISSN">1365-2265</identifier>
<identifier type="DOI">10.1111/(ISSN)1365-2265</identifier>
<identifier type="PublisherID">CEN</identifier>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>45</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>1</number>
</detail>
<extent unit="pages"><start>39</start>
<end>45</end>
<total>7</total>
</extent>
</part>
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<identifier type="istex">81AC0B22444DABEF801A60ED574537C634D6792C</identifier>
<identifier type="DOI">10.1111/j.1365-2265.1996.tb02058.x</identifier>
<identifier type="ArticleID">CEN39</identifier>
<recordInfo><recordContentSource>WILEY</recordContentSource>
<recordOrigin>Blackwell Publishing Ltd</recordOrigin>
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Effect of fenfluramine on episodic ACTH and cortisol secretion

Effect of fenfluramine on episodic ACTH and cortisol secretion

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