A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
Identifieur interne : 005236 ( Main/Merge ); précédent : 005235; suivant : 005237A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
Auteurs : John S. Oxford [Royaume-Uni] ; Robert Lambkin [Royaume-Uni] ; Iain Gibb [Royaume-Uni] ; Shobana Balasingam [Royaume-Uni] ; Charlotte Chan [Royaume-Uni] ; Andrew Catchpole [Royaume-Uni]Source :
- Antiviral chemistry & chemotherapy [ 0956-3202 ] ; 2005.
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- Pascal (Inist)
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- topic : Alcool.
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Abstract
A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log10 TCID50 was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.
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Oxford</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lambkin, Robert" sort="Lambkin, Robert" uniqKey="Lambkin R" first="Robert" last="Lambkin">Robert Lambkin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gibb, Iain" sort="Gibb, Iain" uniqKey="Gibb I" first="Iain" last="Gibb">Iain Gibb</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Boots Healthcare International Ltd, Product Development (Healthcare)</s1><s2>Nottingham</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Balasingam, Shobana" sort="Balasingam, Shobana" uniqKey="Balasingam S" first="Shobana" last="Balasingam">Shobana Balasingam</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chan, Charlotte" sort="Chan, Charlotte" uniqKey="Chan C" first="Charlotte" last="Chan">Charlotte Chan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Catchpole, Andrew" sort="Catchpole, Andrew" uniqKey="Catchpole A" first="Andrew" last="Catchpole">Andrew Catchpole</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Antiviral chemistry & chemotherapy</title><title level="j" type="abbreviated">Antivir. chem. chemother.</title><idno type="ISSN">0956-3202</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral chemistry & chemotherapy</title><title level="j" type="abbreviated">Antivir. chem. chemother.</title><idno type="ISSN">0956-3202</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol</term><term>Amylmetacresol</term><term>Antiviral</term><term>Dosage form</term><term>Human respiratory syncytial virus</term><term>Influenza A</term><term>Influenza A virus</term><term>Oropharynx</term><term>Respiratory tract</term><term>Rhinovirus</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Oropharynx</term><term>Alcool</term><term>Antiviral</term><term>Virus respiratoire syncytial humain</term><term>Voie respiratoire</term><term>Virus grippal A</term><term>Syndrome respiratoire aigu sévère</term><term>Grippe A</term><term>Rhinovirus</term><term>Forme pharmaceutique</term><term>Amylmétacrésol</term><term>Dichlorobenzyl Alcool</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Alcool</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log<sub>10</sub> TCID<sub>50</sub> was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Oxford, John S" sort="Oxford, John S" uniqKey="Oxford J" first="John S." last="Oxford">John S. Oxford</name></region><name sortKey="Balasingam, Shobana" sort="Balasingam, Shobana" uniqKey="Balasingam S" first="Shobana" last="Balasingam">Shobana Balasingam</name><name sortKey="Catchpole, Andrew" sort="Catchpole, Andrew" uniqKey="Catchpole A" first="Andrew" last="Catchpole">Andrew Catchpole</name><name sortKey="Chan, Charlotte" sort="Chan, Charlotte" uniqKey="Chan C" first="Charlotte" last="Chan">Charlotte Chan</name><name sortKey="Gibb, Iain" sort="Gibb, Iain" uniqKey="Gibb I" first="Iain" last="Gibb">Iain Gibb</name><name sortKey="Lambkin, Robert" sort="Lambkin, Robert" uniqKey="Lambkin R" first="Robert" last="Lambkin">Robert Lambkin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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