SrasV1, PascalFrancis, Corpus, bibRecord, 000657

A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV

Identifieur interne : 000657 ( PascalFrancis/Corpus ); précédent : 000656; suivant : 000658

A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV

Auteurs : John S. Oxford ; Robert Lambkin ; Iain Gibb ; Shobana Balasingam ; Charlotte Chan ; Andrew Catchpole

Source :

Antiviral chemistry & chemotherapy [ 0956-3202 ] ; 2005.

RBID : Pascal:05-0281109

Descripteurs français

Pascal (Inist)
- Oropharynx, Alcool, Antiviral, Virus respiratoire syncytial humain, Voie respiratoire, Virus grippal A, Syndrome respiratoire aigu sévère, Grippe A, Rhinovirus, Forme pharmaceutique, Amylmétacrésol, Dichlorobenzyl Alcool.

English descriptors

KwdEn :
- Alcohol, Amylmetacresol, Antiviral, Dosage form, Human respiratory syncytial virus, Influenza A, Influenza A virus, Oropharynx, Respiratory tract, Rhinovirus, Severe acute respiratory syndrome.

Abstract

A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log₁₀ TCID₅₀ was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0956-3202`
A03		`1`		`@0 Antivir. chem. chemother.`
A05				`@2 16`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV`
A11	`01`	`1`		`@1 OXFORD (John S.)`
A11	`02`	`1`		`@1 LAMBKIN (Robert)`
A11	`03`	`1`		`@1 GIBB (Iain)`
A11	`04`	`1`		`@1 BALASINGAM (Shobana)`
A11	`05`	`1`		`@1 CHAN (Charlotte)`
A11	`06`	`1`		`@1 CATCHPOLE (Andrew)`
A14	`01`			`@1 Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry @2 London @3 GBR @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Boots Healthcare International Ltd, Product Development (Healthcare) @2 Nottingham @3 GBR @Z 3 aut.`
A20				`@1 129-134`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 22101 @5 354000125989760050`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 24 ref.`
A47	`01`	`1`		`@0 05-0281109`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral chemistry & chemotherapy`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log₁₀ TCID₅₀ was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Oropharynx @5 01`
C03	`01`	`X`	`ENG`	`@0 Oropharynx @5 01`
C03	`01`	`X`	`SPA`	`@0 Orofaringe @5 01`
C03	`02`	`X`	`FRE`	`@0 Alcool @5 02`
C03	`02`	`X`	`ENG`	`@0 Alcohol @5 02`
C03	`02`	`X`	`SPA`	`@0 Alcohol @5 02`
C03	`03`	`X`	`FRE`	`@0 Antiviral @5 03`
C03	`03`	`X`	`ENG`	`@0 Antiviral @5 03`
C03	`03`	`X`	`SPA`	`@0 Antiviral @5 03`
C03	`04`	`X`	`FRE`	`@0 Virus respiratoire syncytial humain @2 NW @5 04`
C03	`04`	`X`	`ENG`	`@0 Human respiratory syncytial virus @2 NW @5 04`
C03	`04`	`X`	`SPA`	`@0 Human respiratory syncytial virus @2 NW @5 04`
C03	`05`	`X`	`FRE`	`@0 Voie respiratoire @5 05`
C03	`05`	`X`	`ENG`	`@0 Respiratory tract @5 05`
C03	`05`	`X`	`SPA`	`@0 Vía respiratoria @5 05`
C03	`06`	`X`	`FRE`	`@0 Virus grippal A @2 NW @5 06`
C03	`06`	`X`	`ENG`	`@0 Influenza A virus @2 NW @5 06`
C03	`06`	`X`	`SPA`	`@0 Influenza A virus @2 NW @5 06`
C03	`07`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 08`
C03	`07`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 08`
C03	`07`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 08`
C03	`08`	`X`	`FRE`	`@0 Grippe A @5 09`
C03	`08`	`X`	`ENG`	`@0 Influenza A @5 09`
C03	`08`	`X`	`SPA`	`@0 Gripe A @5 09`
C03	`09`	`X`	`FRE`	`@0 Rhinovirus @2 NW @5 10`
C03	`09`	`X`	`ENG`	`@0 Rhinovirus @2 NW @5 10`
C03	`09`	`X`	`SPA`	`@0 Rhinovirus @2 NW @5 10`
C03	`10`	`X`	`FRE`	`@0 Forme pharmaceutique @5 11`
C03	`10`	`X`	`ENG`	`@0 Dosage form @5 11`
C03	`10`	`X`	`SPA`	`@0 Forma farmacéutica @5 11`
C03	`11`	`X`	`FRE`	`@0 Amylmétacrésol @2 NK @2 FR @5 12`
C03	`11`	`X`	`ENG`	`@0 Amylmetacresol @2 NK @2 FR @5 12`
C03	`11`	`X`	`SPA`	`@0 Amilmetacresol @2 NK @2 FR @5 12`
C03	`12`	`X`	`FRE`	`@0 Dichlorobenzyl Alcool @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Pneumovirus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Pneumovirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Pneumovirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Pneumovirinae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Pneumovirinae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Pneumovirinae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Paramyxoviridae @2 NW`
C07	`03`	`X`	`ENG`	`@0 Paramyxoviridae @2 NW`
C07	`03`	`X`	`SPA`	`@0 Paramyxoviridae @2 NW`
C07	`04`	`X`	`FRE`	`@0 Mononegavirales @2 NW`
C07	`04`	`X`	`ENG`	`@0 Mononegavirales @2 NW`
C07	`04`	`X`	`SPA`	`@0 Mononegavirales @2 NW`
C07	`05`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`05`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`05`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`06`	`X`	`FRE`	`@0 Influenzavirus A @2 NW`
C07	`06`	`X`	`ENG`	`@0 Influenzavirus A @2 NW`
C07	`06`	`X`	`SPA`	`@0 Influenzavirus A @2 NW`
C07	`07`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`07`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`07`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
C07	`08`	`X`	`FRE`	`@0 Virose`
C07	`08`	`X`	`ENG`	`@0 Viral disease`
C07	`08`	`X`	`SPA`	`@0 Virosis`
C07	`09`	`X`	`FRE`	`@0 Infection`
C07	`09`	`X`	`ENG`	`@0 Infection`
C07	`09`	`X`	`SPA`	`@0 Infección`
C07	`10`	`X`	`FRE`	`@0 Picornaviridae @2 NW`
C07	`10`	`X`	`ENG`	`@0 Picornaviridae @2 NW`
C07	`10`	`X`	`SPA`	`@0 Picornaviridae @2 NW`
C07	`11`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`11`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`11`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`12`	`X`	`FRE`	`@0 Poumon pathologie @5 38`
C07	`12`	`X`	`ENG`	`@0 Lung disease @5 38`
C07	`12`	`X`	`SPA`	`@0 Pulmón patología @5 38`
N21				`@1 192`

Format Inist (serveur)

NO :	PASCAL 05-0281109 INIST
ET :	A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
AU :	OXFORD (John S.); LAMBKIN (Robert); GIBB (Iain); BALASINGAM (Shobana); CHAN (Charlotte); CATCHPOLE (Andrew)
AF :	Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry/London/Royaume-Uni (1 aut., 2 aut., 4 aut., 5 aut., 6 aut.); Boots Healthcare International Ltd, Product Development (Healthcare)/Nottingham/Royaume-Uni (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Antiviral chemistry & chemotherapy; ISSN 0956-3202; Royaume-Uni; Da. 2005; Vol. 16; No. 2; Pp. 129-134; Bibl. 24 ref.
LA :	Anglais
EA :	A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log₁₀ TCID₅₀ was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.
CC :	002B02S05
FD :	Oropharynx; Alcool; Antiviral; Virus respiratoire syncytial humain; Voie respiratoire; Virus grippal A; Syndrome respiratoire aigu sévère; Grippe A; Rhinovirus; Forme pharmaceutique; Amylmétacrésol; Dichlorobenzyl Alcool
FG :	Pneumovirus; Pneumovirinae; Paramyxoviridae; Mononegavirales; Virus; Influenzavirus A; Orthomyxoviridae; Virose; Infection; Picornaviridae; Appareil respiratoire pathologie; Poumon pathologie
ED :	Oropharynx; Alcohol; Antiviral; Human respiratory syncytial virus; Respiratory tract; Influenza A virus; Severe acute respiratory syndrome; Influenza A; Rhinovirus; Dosage form; Amylmetacresol
EG :	Pneumovirus; Pneumovirinae; Paramyxoviridae; Mononegavirales; Virus; Influenzavirus A; Orthomyxoviridae; Viral disease; Infection; Picornaviridae; Respiratory disease; Lung disease
SD :	Orofaringe; Alcohol; Antiviral; Human respiratory syncytial virus; Vía respiratoria; Influenza A virus; Síndrome respiratorio agudo severo; Gripe A; Rhinovirus; Forma farmacéutica; Amilmetacresol
LO :	INIST-22101.354000125989760050
ID :	05-0281109

Links to Exploration step

Pascal:05-0281109

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol</term>
<term>Amylmetacresol</term>
<term>Antiviral</term>
<term>Dosage form</term>
<term>Human respiratory syncytial virus</term>
<term>Influenza A</term>
<term>Influenza A virus</term>
<term>Oropharynx</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Oropharynx</term>
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<front><div type="abstract" xml:lang="en">A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log<sub>10</sub>
 TCID<sub>50</sub>
 was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0956-3202</s0>
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<fA08 i1="01" i2="1" l="ENG"><s1>A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV</s1>
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<fA11 i1="01" i2="1"><s1>OXFORD (John S.)</s1>
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<fA11 i1="02" i2="1"><s1>LAMBKIN (Robert)</s1>
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<fA11 i1="03" i2="1"><s1>GIBB (Iain)</s1>
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<fA11 i1="04" i2="1"><s1>BALASINGAM (Shobana)</s1>
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<fA11 i1="05" i2="1"><s1>CHAN (Charlotte)</s1>
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<fA11 i1="06" i2="1"><s1>CATCHPOLE (Andrew)</s1>
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<fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Boots Healthcare International Ltd, Product Development (Healthcare)</s1>
<s2>Nottingham</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA20><s1>129-134</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>22101</s2>
<s5>354000125989760050</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0281109</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Antiviral chemistry & chemotherapy</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log<sub>10</sub>
 TCID<sub>50</sub>
 was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Oropharynx</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Oropharynx</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Orofaringe</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Alcool</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Alcohol</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Alcohol</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Virus respiratoire syncytial humain</s0>
<s2>NW</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Human respiratory syncytial virus</s0>
<s2>NW</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Human respiratory syncytial virus</s0>
<s2>NW</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Voie respiratoire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Respiratory tract</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Vía respiratoria</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Virus grippal A</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Grippe A</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Influenza A</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Gripe A</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Rhinovirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Rhinovirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Rhinovirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Forme pharmaceutique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Dosage form</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Forma farmacéutica</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Amylmétacrésol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Amylmetacresol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Amilmetacresol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Dichlorobenzyl Alcool</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pneumovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Pneumovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Pneumovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pneumovirinae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Pneumovirinae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Pneumovirinae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Paramyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Paramyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Paramyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mononegavirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Picornaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Picornaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Picornaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>192</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 05-0281109 INIST</NO>
<ET>A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV</ET>
<AU>OXFORD (John S.); LAMBKIN (Robert); GIBB (Iain); BALASINGAM (Shobana); CHAN (Charlotte); CATCHPOLE (Andrew)</AU>
<AF>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry/London/Royaume-Uni (1 aut., 2 aut., 4 aut., 5 aut., 6 aut.); Boots Healthcare International Ltd, Product Development (Healthcare)/Nottingham/Royaume-Uni (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Antiviral chemistry & chemotherapy; ISSN 0956-3202; Royaume-Uni; Da. 2005; Vol. 16; No. 2; Pp. 129-134; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log<sub>10</sub>
 TCID<sub>50</sub>
 was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.</EA>
<CC>002B02S05</CC>
<FD>Oropharynx; Alcool; Antiviral; Virus respiratoire syncytial humain; Voie respiratoire; Virus grippal A; Syndrome respiratoire aigu sévère; Grippe A; Rhinovirus; Forme pharmaceutique; Amylmétacrésol; Dichlorobenzyl Alcool</FD>
<FG>Pneumovirus; Pneumovirinae; Paramyxoviridae; Mononegavirales; Virus; Influenzavirus A; Orthomyxoviridae; Virose; Infection; Picornaviridae; Appareil respiratoire pathologie; Poumon pathologie</FG>
<ED>Oropharynx; Alcohol; Antiviral; Human respiratory syncytial virus; Respiratory tract; Influenza A virus; Severe acute respiratory syndrome; Influenza A; Rhinovirus; Dosage form; Amylmetacresol</ED>
<EG>Pneumovirus; Pneumovirinae; Paramyxoviridae; Mononegavirales; Virus; Influenzavirus A; Orthomyxoviridae; Viral disease; Infection; Picornaviridae; Respiratory disease; Lung disease</EG>
<SD>Orofaringe; Alcohol; Antiviral; Human respiratory syncytial virus; Vía respiratoria; Influenza A virus; Síndrome respiratorio agudo severo; Gripe A; Rhinovirus; Forma farmacéutica; Amilmetacresol</SD>
<LO>INIST-22101.354000125989760050</LO>
<ID>05-0281109</ID>
</server>
</inist>
</record>

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A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV

A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV

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