SrasV1, Main, Merge, bibRecord, 005237

A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARs-CoV-neutralizing antibodies

Identifieur interne : 005237 ( Main/Merge ); précédent : 005236; suivant : 005238

A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARs-CoV-neutralizing antibodies

Auteurs : Milosz Faber [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Anjeanette Roberts [États-Unis] ; Amy B. Rice [États-Unis] ; Hilary Koprowski [États-Unis] ; Bernhard Dietzschold [États-Unis] ; Matthias J. Schnell [États-Unis]

Source :

Journal of general virology [ 0022-1317 ] ; 2005.

RBID : Pascal:05-0229124

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Immunisation, Vaccin, Vecteur, Protéine, Anticorps neutralisant, Microbiologie, Virologie, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Immunization, Microbiology, Neutralizing antibody, Protein, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vaccine, Vector, Virology.

Abstract

Foreign viral proteins expressed by rabies virus (RV) have been shown to induce potent humoral and cellular immune responses in immunized animals. In addition, highly attenuated and, therefore, very safe RV-based vectors have been constructed. Here, an RV-based vaccine vehicle was utilized as a novel vaccine against severe acute respiratory syndrome coronavirus (SARS-CoV). For this approach, the SARS-CoV nucleocapsid protein (N) or envelope spike protein (S) genes were cloned between the RV glycoprotein G and polymerase L genes. Recombinant vectors expressing SARS-CoV N or S protein were recovered and their immunogenicity was studied in mice. A single inoculation with the RV-based vaccine expressing SARS-CoV S protein induced a strong SARS-CoV-neutralizing antibody response. The ability of the RV-SARS-CoV S vector to confer immunity after a single inoculation makes this live vaccine a promising candidate for eradication of SARS-CoV in animal reservoirs, thereby reducing the risk of transmitting the infection to humans.

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Pascal:05-0229124

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Immunization</term>
<term>Microbiology</term>
<term>Neutralizing antibody</term>
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<term>Severe acute respiratory syndrome virus</term>
<term>Vaccine</term>
<term>Vector</term>
<term>Virology</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term>
<term>Immunisation</term>
<term>Vaccin</term>
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<term>Protéine</term>
<term>Anticorps neutralisant</term>
<term>Microbiologie</term>
<term>Virologie</term>
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<front><div type="abstract" xml:lang="en">Foreign viral proteins expressed by rabies virus (RV) have been shown to induce potent humoral and cellular immune responses in immunized animals. In addition, highly attenuated and, therefore, very safe RV-based vectors have been constructed. Here, an RV-based vaccine vehicle was utilized as a novel vaccine against severe acute respiratory syndrome coronavirus (SARS-CoV). For this approach, the SARS-CoV nucleocapsid protein (N) or envelope spike protein (S) genes were cloned between the RV glycoprotein G and polymerase L genes. Recombinant vectors expressing SARS-CoV N or S protein were recovered and their immunogenicity was studied in mice. A single inoculation with the RV-based vaccine expressing SARS-CoV S protein induced a strong SARS-CoV-neutralizing antibody response. The ability of the RV-SARS-CoV S vector to confer immunity after a single inoculation makes this live vaccine a promising candidate for eradication of SARS-CoV in animal reservoirs, thereby reducing the risk of transmitting the infection to humans.</div>
</front>
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<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Faber, Milosz" sort="Faber, Milosz" uniqKey="Faber M" first="Milosz" last="Faber">Milosz Faber</name>
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<name sortKey="Schnell, Matthias J" sort="Schnell, Matthias J" uniqKey="Schnell M" first="Matthias J." last="Schnell">Matthias J. Schnell</name>
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A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARs-CoV-neutralizing antibodies

A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARs-CoV-neutralizing antibodies

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri