Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
Identifieur interne : 004336 ( Main/Merge ); précédent : 004335; suivant : 004337Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
Auteurs : Hongwei Shao [République populaire de Chine] ; Dongming Lan [République populaire de Chine] ; Zhaohui Duan [République populaire de Chine] ; Zehuan Liu [République populaire de Chine] ; Jun Min [République populaire de Chine] ; Lichun Zhang [République populaire de Chine] ; Jian Huang [République populaire de Chine] ; Jing Su [République populaire de Chine] ; Shangwu Chen [République populaire de Chine] ; Anlong Xu [République populaire de Chine]Source :
- Journal of Clinical Immunology [ 0271-9142 ] ; 2006-11-01.
Descripteurs français
- KwdFr :
- ADN mitochondrial (analyse), Adulte, Agranulocytes (métabolisme), Agranulocytes (virologie), Analyse de profil d'expression de gènes, Femelle, Gènes de mitochondrie, Humains, Hybridation d'acides nucléiques, Microscopie électronique, Microscopie électronique à transmission, RT-PCR, Régulation positive, Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Techniques in vitro, Virus du SRAS (métabolisme).
- MESH :
- analyse : ADN mitochondrial.
- métabolisme : Agranulocytes, Syndrome respiratoire aigu sévère, Virus du SRAS.
- virologie : Agranulocytes, Syndrome respiratoire aigu sévère.
- Adulte, Analyse de profil d'expression de gènes, Femelle, Gènes de mitochondrie, Humains, Hybridation d'acides nucléiques, Microscopie électronique, Microscopie électronique à transmission, RT-PCR, Régulation positive, Techniques in vitro.
English descriptors
- KwdEn :
- Adult, DNA, Mitochondrial (analysis), Female, Gene Expression Profiling, Genes, Mitochondrial, Humans, In Vitro Techniques, Leukocytes, Mononuclear (metabolism), Leukocytes, Mononuclear (virology), Microscopy, Electron, Microscopy, Electron, Transmission, Nucleic Acid Hybridization, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (metabolism), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Up-Regulation, mitochondria, peripheral blood mononuclear cell, suppression subtractive hybridization.
- MESH :
- chemical , analysis : DNA, Mitochondrial.
- metabolism : Leukocytes, Mononuclear, SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Leukocytes, Mononuclear, Severe Acute Respiratory Syndrome.
- Adult, Female, Gene Expression Profiling, Genes, Mitochondrial, Humans, In Vitro Techniques, Microscopy, Electron, Microscopy, Electron, Transmission, Nucleic Acid Hybridization, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation.
Abstract
The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.
Url:
- https://api.istex.fr/ark:/67375/VQC-WF136QD8-4/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086694
DOI: 10.1007/s10875-006-9046-y
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<term>Genes, Mitochondrial</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
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<term>Leukocytes, Mononuclear (virology)</term>
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<term>Microscopy, Electron, Transmission</term>
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<term>Analyse de profil d'expression de gènes</term>
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<term>Gènes de mitochondrie</term>
<term>Humains</term>
<term>Hybridation d'acides nucléiques</term>
<term>Microscopie électronique</term>
<term>Microscopie électronique à transmission</term>
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<front><div type="abstract" xml:lang="en">The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.</div>
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<wicri:regionArea>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University, 510120, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Zehuan" sort="Liu, Zehuan" uniqKey="Liu Z" first="Zehuan" last="Liu">Zehuan Liu</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biocontrol, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, 510275, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University, 510120, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Lichun" sort="Zhang, Lichun" uniqKey="Zhang L" first="Lichun" last="Zhang">Lichun Zhang</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biocontrol, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, 510275, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University, 510120, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Su, Jing" sort="Su, Jing" uniqKey="Su J" first="Jing" last="Su">Jing Su</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biocontrol, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, 510275, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biocontrol, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, 510275, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Biocontrol, Department of Biochemistry, College of Life Sciences, Sun Yat-sen (Zhongshan) University, 510275, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Clinical Immunology</title>
<title level="j" type="abbrev">J Clin Immunol</title>
<idno type="ISSN">0271-9142</idno>
<idno type="eISSN">1573-2592</idno>
<imprint><publisher>Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2006-11-01">2006-11-01</date>
<biblScope unit="volume">26</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="546">546</biblScope>
<biblScope unit="page" to="554">554</biblScope>
</imprint>
<idno type="ISSN">0271-9142</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0271-9142</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Severe acute respiratory syndrome</term>
<term>mitochondria</term>
<term>peripheral blood mononuclear cell</term>
<term>suppression subtractive hybridization</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.</div>
</front>
</TEI>
</ISTEX>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients</title>
<author><name sortKey="Shao, Hongwei" sort="Shao, Hongwei" uniqKey="Shao H" first="Hongwei" last="Shao">Hongwei Shao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lan, Dongming" sort="Lan, Dongming" uniqKey="Lan D" first="Dongming" last="Lan">Dongming Lan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duan, Zhaohui" sort="Duan, Zhaohui" uniqKey="Duan Z" first="Zhaohui" last="Duan">Zhaohui Duan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510120 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510120 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Zehuan" sort="Liu, Zehuan" uniqKey="Liu Z" first="Zehuan" last="Liu">Zehuan Liu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510120 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510120 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Lichun" sort="Zhang, Lichun" uniqKey="Zhang L" first="Lichun" last="Zhang">Lichun Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510120 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510120 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Su, Jing" sort="Su, Jing" uniqKey="Su J" first="Jing" last="Su">Jing Su</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17024565</idno>
<idno type="pmc">7086694</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086694</idno>
<idno type="RBID">PMC:7086694</idno>
<idno type="doi">10.1007/s10875-006-9046-y</idno>
<date when="2006">2006</date>
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<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001018</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:17024565</idno>
<idno type="wicri:Area/PubMed/Corpus">002069</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002069</idno>
<idno type="wicri:Area/PubMed/Curation">002069</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002069</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F34</idno>
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<idno type="wicri:Area/Ncbi/Merge">001681</idno>
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<idno type="wicri:doubleKey">0271-9142:2006:Shao H:upregulation:of:mitochondrial</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients</title>
<author><name sortKey="Shao, Hongwei" sort="Shao, Hongwei" uniqKey="Shao H" first="Hongwei" last="Shao">Hongwei Shao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lan, Dongming" sort="Lan, Dongming" uniqKey="Lan D" first="Dongming" last="Lan">Dongming Lan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duan, Zhaohui" sort="Duan, Zhaohui" uniqKey="Duan Z" first="Zhaohui" last="Duan">Zhaohui Duan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510120 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510120 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Zehuan" sort="Liu, Zehuan" uniqKey="Liu Z" first="Zehuan" last="Liu">Zehuan Liu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510120 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510120 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Lichun" sort="Zhang, Lichun" uniqKey="Zhang L" first="Lichun" last="Zhang">Lichun Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510120 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510120 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Su, Jing" sort="Su, Jing" uniqKey="Su J" first="Jing" last="Su">Jing Su</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution-id institution-id-type="ISNI">000000012360039X</institution-id>
<institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution>
<institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution>
</institution-wrap>
510275 Guangzhou, P. R. China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>510275 Guangzhou</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical Immunology</title>
<idno type="ISSN">0271-9142</idno>
<idno type="eISSN">1573-2592</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>DNA, Mitochondrial (analysis)</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Genes, Mitochondrial</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Leukocytes, Mononuclear (metabolism)</term>
<term>Leukocytes, Mononuclear (virology)</term>
<term>Microscopy, Electron</term>
<term>Microscopy, Electron, Transmission</term>
<term>Nucleic Acid Hybridization</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>SARS Virus (metabolism)</term>
<term>Severe Acute Respiratory Syndrome (metabolism)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Up-Regulation</term>
</keywords>
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<term>Adulte</term>
<term>Agranulocytes (métabolisme)</term>
<term>Agranulocytes (virologie)</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Femelle</term>
<term>Gènes de mitochondrie</term>
<term>Humains</term>
<term>Hybridation d'acides nucléiques</term>
<term>Microscopie électronique</term>
<term>Microscopie électronique à transmission</term>
<term>RT-PCR</term>
<term>Régulation positive</term>
<term>Syndrome respiratoire aigu sévère (métabolisme)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Techniques in vitro</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Mitochondrial</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ADN mitochondrial</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agranulocytes</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Agranulocytes</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Gene Expression Profiling</term>
<term>Genes, Mitochondrial</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Microscopy, Electron</term>
<term>Microscopy, Electron, Transmission</term>
<term>Nucleic Acid Hybridization</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Up-Regulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Femelle</term>
<term>Gènes de mitochondrie</term>
<term>Humains</term>
<term>Hybridation d'acides nucléiques</term>
<term>Microscopie électronique</term>
<term>Microscopie électronique à transmission</term>
<term>RT-PCR</term>
<term>Régulation positive</term>
<term>Techniques in vitro</term>
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<front><div type="abstract" xml:lang="en"><p>The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV <italic>in vivo</italic>
. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name>
</author>
<author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name>
</author>
<author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Yam, Lyc" uniqKey="Yam L">LYC Yam</name>
</author>
<author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name>
</author>
<author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name>
</author>
<author><name sortKey="Yee, Wks" uniqKey="Yee W">WKS Yee</name>
</author>
<author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name>
</author>
<author><name sortKey="Cheung, Mt" uniqKey="Cheung M">MT Cheung</name>
</author>
<author><name sortKey="Cheng, Vcc" uniqKey="Cheng V">VCC Cheng</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Tsang, Dnc" uniqKey="Tsang D">DNC Tsang</name>
</author>
<author><name sortKey="Yung, Rwh" uniqKey="Yung R">RWH Yung</name>
</author>
<author><name sortKey="Ng, Tk" uniqKey="Ng T">TK Ng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name>
</author>
<author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name>
</author>
<author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name>
</author>
<author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name>
</author>
<author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name>
</author>
<author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name>
</author>
<author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name>
</author>
<author><name sortKey="Corner, Ja" uniqKey="Corner J">JA Corner</name>
</author>
<author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name>
</author>
<author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name>
</author>
<author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
<author><name sortKey="Humphrey, Cd" uniqKey="Humphrey C">CD Humphrey</name>
</author>
<author><name sortKey="Shieh, Wj" uniqKey="Shieh W">WJ Shieh</name>
</author>
<author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name>
</author>
<author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name>
</author>
<author><name sortKey="Rota, P" uniqKey="Rota P">P Rota</name>
</author>
<author><name sortKey="Fields, B" uniqKey="Fields B">B Fields</name>
</author>
<author><name sortKey="Derisi, J" uniqKey="Derisi J">J DeRisi</name>
</author>
<author><name sortKey="Yang, Jy" uniqKey="Yang J">JY Yang</name>
</author>
<author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name>
</author>
<author><name sortKey="Hughes, Jm" uniqKey="Hughes J">JM Hughes</name>
</author>
<author><name sortKey="Leduc, Jw" uniqKey="Leduc J">JW LeDuc</name>
</author>
<author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name>
</author>
<author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Sahly, Hm" uniqKey="El Sahly H">HM El-Sahly</name>
</author>
<author><name sortKey="Atmar, Rl" uniqKey="Atmar R">RL Atmar</name>
</author>
<author><name sortKey="Glezen, Wp" uniqKey="Glezen W">WP Glezen</name>
</author>
<author><name sortKey="Greenberg, Sb" uniqKey="Greenberg S">SB Greenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falsey, Ar" uniqKey="Falsey A">AR Falsey</name>
</author>
<author><name sortKey="Walsh, Ee" uniqKey="Walsh E">EE Walsh</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name>
</author>
<author><name sortKey="Robinson, Jl" uniqKey="Robinson J">JL Robinson</name>
</author>
<author><name sortKey="Tse, A" uniqKey="Tse A">A Tse</name>
</author>
<author><name sortKey="Lee, Be" uniqKey="Lee B">BE Lee</name>
</author>
<author><name sortKey="Hart, L" uniqKey="Hart L">L Hart</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Wh" uniqKey="Li W">WH Li</name>
</author>
<author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name>
</author>
<author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N Vasilieva</name>
</author>
<author><name sortKey="Sui, Jh" uniqKey="Sui J">JH Sui</name>
</author>
<author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name>
</author>
<author><name sortKey="Berne, Ma" uniqKey="Berne M">MA Berne</name>
</author>
<author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M Somasundaran</name>
</author>
<author><name sortKey="Sullivan, Jl" uniqKey="Sullivan J">JL Sullivan</name>
</author>
<author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K Luzuriaga</name>
</author>
<author><name sortKey="Greenough, Tc" uniqKey="Greenough T">TC Greenough</name>
</author>
<author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name>
</author>
<author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hofmann, H" uniqKey="Hofmann H">H Hofmann</name>
</author>
<author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name>
</author>
<author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L Van Der Hoek</name>
</author>
<author><name sortKey="Geier, M" uniqKey="Geier M">M Geier</name>
</author>
<author><name sortKey="Berkhout, B" uniqKey="Berkhout B">B Berkhout</name>
</author>
<author><name sortKey="Pohlmann, S" uniqKey="Pohlmann S">S Pohlmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiu, Wk" uniqKey="Chiu W">WK Chiu</name>
</author>
<author><name sortKey="Cheung, Pc" uniqKey="Cheung P">PC Cheung</name>
</author>
<author><name sortKey="Ng, Kl" uniqKey="Ng K">KL Ng</name>
</author>
<author><name sortKey="Ip, Pl" uniqKey="Ip P">PL Ip</name>
</author>
<author><name sortKey="Sugunan, Vk" uniqKey="Sugunan V">VK Sugunan</name>
</author>
<author><name sortKey="Luk, Dc" uniqKey="Luk D">DC Luk</name>
</author>
<author><name sortKey="Ma, Lc" uniqKey="Ma L">LC Ma</name>
</author>
<author><name sortKey="Chan, Bh" uniqKey="Chan B">BH Chan</name>
</author>
<author><name sortKey="Lo, Kl" uniqKey="Lo K">KL Lo</name>
</author>
<author><name sortKey="Lai, Wm" uniqKey="Lai W">WM Lai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, Aw" uniqKey="Lo A">AW Lo</name>
</author>
<author><name sortKey="Tang, Nl" uniqKey="Tang N">NL Tang</name>
</author>
<author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Wo, J" uniqKey="Wo J">J Wo</name>
</author>
<author><name sortKey="Shao, J" uniqKey="Shao J">J Shao</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
<author><name sortKey="Yao, H" uniqKey="Yao H">H Yao</name>
</author>
<author><name sortKey="Hu, M" uniqKey="Hu M">M Hu</name>
</author>
<author><name sortKey="Dennin, Rh" uniqKey="Dennin R">RH Dennin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Ts" uniqKey="Li T">TS Li</name>
</author>
<author><name sortKey="Qiu, Zf" uniqKey="Qiu Z">ZF Qiu</name>
</author>
<author><name sortKey="Zhang, Lq" uniqKey="Zhang L">LQ Zhang</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
<author><name sortKey="He, W" uniqKey="He W">W He</name>
</author>
<author><name sortKey="Liu, Zy" uniqKey="Liu Z">ZY Liu</name>
</author>
<author><name sortKey="Ma, Xj" uniqKey="Ma X">XJ Ma</name>
</author>
<author><name sortKey="Fan, Hw" uniqKey="Fan H">HW Fan</name>
</author>
<author><name sortKey="Lu, W" uniqKey="Lu W">W Lu</name>
</author>
<author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name>
</author>
<author><name sortKey="Wang, A" uniqKey="Wang A">A Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcwhirter, Sm" uniqKey="Mcwhirter S">SM McWhirter</name>
</author>
<author><name sortKey="Tenoever, Br" uniqKey="Tenoever B">BR Tenoever</name>
</author>
<author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T Maniatis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seth, Rb" uniqKey="Seth R">RB Seth</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Chen, Zj" uniqKey="Chen Z">ZJ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Tang, F" uniqKey="Tang F">F Tang</name>
</author>
<author><name sortKey="Fontanet, A" uniqKey="Fontanet A">A Fontanet</name>
</author>
<author><name sortKey="Zhan, L" uniqKey="Zhan L">L Zhan</name>
</author>
<author><name sortKey="Zhao, Qm" uniqKey="Zhao Q">QM Zhao</name>
</author>
<author><name sortKey="Zhang, Ph" uniqKey="Zhang P">PH Zhang</name>
</author>
<author><name sortKey="Wu, Xm" uniqKey="Wu X">XM Wu</name>
</author>
<author><name sortKey="Zuo, Sq" uniqKey="Zuo S">SQ Zuo</name>
</author>
<author><name sortKey="Baril, L" uniqKey="Baril L">L Baril</name>
</author>
<author><name sortKey="Vabret, A" uniqKey="Vabret A">A Vabret</name>
</author>
<author><name sortKey="Xin, Zt" uniqKey="Xin Z">ZT Xin</name>
</author>
<author><name sortKey="Shao, Ym" uniqKey="Shao Y">YM Shao</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
<author><name sortKey="Cao, Wc" uniqKey="Cao W">WC Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name>
</author>
<author><name sortKey="Leung, Ws" uniqKey="Leung W">WS Leung</name>
</author>
<author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Lin, Aw" uniqKey="Lin A">AW Lin</name>
</author>
<author><name sortKey="Chan, Vl" uniqKey="Chan V">VL Chan</name>
</author>
<author><name sortKey="Lam, Jy" uniqKey="Lam J">JY Lam</name>
</author>
<author><name sortKey="Chan, Ks" uniqKey="Chan K">KS Chan</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clayton, Da" uniqKey="Clayton D">DA Clayton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ojala, D" uniqKey="Ojala D">D Ojala</name>
</author>
<author><name sortKey="Crews, S" uniqKey="Crews S">S Crews</name>
</author>
<author><name sortKey="Montoya, J" uniqKey="Montoya J">J Montoya</name>
</author>
<author><name sortKey="Gelfand, R" uniqKey="Gelfand R">R Gelfand</name>
</author>
<author><name sortKey="Attardi, G" uniqKey="Attardi G">G Attardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Dy" uniqKey="Lee D">DY Lee</name>
</author>
<author><name sortKey="Clayton, Da" uniqKey="Clayton D">DA Clayton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
<author><name sortKey="Hedley, Aj" uniqKey="Hedley A">AJ Hedley</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Abu Raddad, Lj" uniqKey="Abu Raddad L">LJ Abu-Raddad</name>
</author>
<author><name sortKey="Ho, Lm" uniqKey="Ho L">LM Ho</name>
</author>
<author><name sortKey="Thach, Tq" uniqKey="Thach T">TQ Thach</name>
</author>
<author><name sortKey="Chau, P" uniqKey="Chau P">P Chau</name>
</author>
<author><name sortKey="Chan, Kp" uniqKey="Chan K">KP Chan</name>
</author>
<author><name sortKey="Lam, Th" uniqKey="Lam T">TH Lam</name>
</author>
<author><name sortKey="Tse, Ly" uniqKey="Tse L">LY Tse</name>
</author>
<author><name sortKey="Tsang, T" uniqKey="Tsang T">T Tsang</name>
</author>
<author><name sortKey="Liu, Sh" uniqKey="Liu S">SH Liu</name>
</author>
<author><name sortKey="Kong, Jh" uniqKey="Kong J">JH Kong</name>
</author>
<author><name sortKey="Lau, Em" uniqKey="Lau E">EM Lau</name>
</author>
<author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
<author><name sortKey="Anderson, Rm" uniqKey="Anderson R">RM Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kakuda, Tn" uniqKey="Kakuda T">TN Kakuda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miro, O" uniqKey="Miro O">O Miro</name>
</author>
<author><name sortKey="Lopez, S" uniqKey="Lopez S">S Lopez</name>
</author>
<author><name sortKey="Rodriguez De La Concepcion, M" uniqKey="Rodriguez De La Concepcion M">M Rodriguez de la Concepcion</name>
</author>
<author><name sortKey="Martinez, E" uniqKey="Martinez E">E Martinez</name>
</author>
<author><name sortKey="Pedrol, E" uniqKey="Pedrol E">E Pedrol</name>
</author>
<author><name sortKey="Garrabou, G" uniqKey="Garrabou G">G Garrabou</name>
</author>
<author><name sortKey="Giralt, M" uniqKey="Giralt M">M Giralt</name>
</author>
<author><name sortKey="Cardellach, F" uniqKey="Cardellach F">F Cardellach</name>
</author>
<author><name sortKey="Gatell, Jm" uniqKey="Gatell J">JM Gatell</name>
</author>
<author><name sortKey="Vilarroya, F" uniqKey="Vilarroya F">F Vilarroya</name>
</author>
<author><name sortKey="Casademont, J" uniqKey="Casademont J">J Casademont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Itallie, Cm" uniqKey="Van Itallie C">CM Van Itallie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miro, O" uniqKey="Miro O">O Miro</name>
</author>
<author><name sortKey="Lopez, S" uniqKey="Lopez S">S Lopez</name>
</author>
<author><name sortKey="Martinez, E" uniqKey="Martinez E">E Martinez</name>
</author>
<author><name sortKey="Pedrol, E" uniqKey="Pedrol E">E Pedrol</name>
</author>
<author><name sortKey="Milinkovic, A" uniqKey="Milinkovic A">A Milinkovic</name>
</author>
<author><name sortKey="Deig, E" uniqKey="Deig E">E Deig</name>
</author>
<author><name sortKey="Garrabou, G" uniqKey="Garrabou G">G Garrabou</name>
</author>
<author><name sortKey="Casademont, J" uniqKey="Casademont J">J Casademont</name>
</author>
<author><name sortKey="Gatell, Jm" uniqKey="Gatell J">JM Gatell</name>
</author>
<author><name sortKey="Cardellach, F" uniqKey="Cardellach F">F Cardellach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yuan, X" uniqKey="Yuan X">X Yuan</name>
</author>
<author><name sortKey="Shan, Y" uniqKey="Shan Y">Y Shan</name>
</author>
<author><name sortKey="Yao, Z" uniqKey="Yao Z">Z Yao</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Cong, Y" uniqKey="Cong Y">Y Cong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Dong, C" uniqKey="Dong C">C Dong</name>
</author>
<author><name sortKey="Che, Y" uniqKey="Che Y">Y Che</name>
</author>
<author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name>
</author>
<author><name sortKey="Liao, Y" uniqKey="Liao Y">Y Liao</name>
</author>
<author><name sortKey="Sheng, Y" uniqKey="Sheng Y">Y Sheng</name>
</author>
<author><name sortKey="Dong, S" uniqKey="Dong S">S Dong</name>
</author>
<author><name sortKey="Ma, S" uniqKey="Ma S">S Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seth, Rb" uniqKey="Seth R">RB Seth</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Ea, Ck" uniqKey="Ea C">CK Ea</name>
</author>
<author><name sortKey="Chen, Zj" uniqKey="Chen Z">ZJ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Lg" uniqKey="Xu L">LG Xu</name>
</author>
<author><name sortKey="Wang, Yy" uniqKey="Wang Y">YY Wang</name>
</author>
<author><name sortKey="Han, Kj" uniqKey="Han K">KJ Han</name>
</author>
<author><name sortKey="Li, Ly" uniqKey="Li L">LY Li</name>
</author>
<author><name sortKey="Zhai, Z" uniqKey="Zhai Z">Z Zhai</name>
</author>
<author><name sortKey="Shu, Hb" uniqKey="Shu H">HB Shu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawai, T" uniqKey="Kawai T">T Kawai</name>
</author>
<author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K Takahashi</name>
</author>
<author><name sortKey="Sato, S" uniqKey="Sato S">S Sato</name>
</author>
<author><name sortKey="Coban, C" uniqKey="Coban C">C Coban</name>
</author>
<author><name sortKey="Kumar, H" uniqKey="Kumar H">H Kumar</name>
</author>
<author><name sortKey="Kato, H" uniqKey="Kato H">H Kato</name>
</author>
<author><name sortKey="Ishii, Kj" uniqKey="Ishii K">KJ Ishii</name>
</author>
<author><name sortKey="Takeuchi, O" uniqKey="Takeuchi O">O Takeuchi</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meylan, E" uniqKey="Meylan E">E Meylan</name>
</author>
<author><name sortKey="Curran, J" uniqKey="Curran J">J Curran</name>
</author>
<author><name sortKey="Hofmann, K" uniqKey="Hofmann K">K Hofmann</name>
</author>
<author><name sortKey="Moradpour, D" uniqKey="Moradpour D">D Moradpour</name>
</author>
<author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name>
</author>
<author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name>
</author>
<author><name sortKey="Tschopp, J" uniqKey="Tschopp J">J Tschopp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yedavalli, Vs" uniqKey="Yedavalli V">VS Yedavalli</name>
</author>
<author><name sortKey="Shih, Hm" uniqKey="Shih H">HM Shih</name>
</author>
<author><name sortKey="Chiang, Yp" uniqKey="Chiang Y">YP Chiang</name>
</author>
<author><name sortKey="Lu, Cy" uniqKey="Lu C">CY Lu</name>
</author>
<author><name sortKey="Chang, Ly" uniqKey="Chang L">LY Chang</name>
</author>
<author><name sortKey="Chen, My" uniqKey="Chen M">MY Chen</name>
</author>
<author><name sortKey="Chuang, Cy" uniqKey="Chuang C">CY Chuang</name>
</author>
<author><name sortKey="Dayton, Ai" uniqKey="Dayton A">AI Dayton</name>
</author>
<author><name sortKey="Jeang, Kt" uniqKey="Jeang K">KT Jeang</name>
</author>
<author><name sortKey="Huang, Lm" uniqKey="Huang L">LM Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carr, Sm" uniqKey="Carr S">SM Carr</name>
</author>
<author><name sortKey="Carnero, E" uniqKey="Carnero E">E Carnero</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A Garcia-Sastre</name>
</author>
<author><name sortKey="Brownlee, Gg" uniqKey="Brownlee G">GG Brownlee</name>
</author>
<author><name sortKey="Fodor, E" uniqKey="Fodor E">E Fodor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Su, J" uniqKey="Su J">J Su</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Barrett, Jw" uniqKey="Barrett J">JW Barrett</name>
</author>
<author><name sortKey="Irvine, Ts" uniqKey="Irvine T">TS Irvine</name>
</author>
<author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name>
</author>
<author><name sortKey="Mcfadden, G" uniqKey="Mcfadden G">G McFadden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hiraragi, H" uniqKey="Hiraragi H">H Hiraragi</name>
</author>
<author><name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name>
</author>
<author><name sortKey="Phipps, Aj" uniqKey="Phipps A">AJ Phipps</name>
</author>
<author><name sortKey="Silic Benussi, M" uniqKey="Silic Benussi M">M Silic-Benussi</name>
</author>
<author><name sortKey="Ciminale, V" uniqKey="Ciminale V">V Ciminale</name>
</author>
<author><name sortKey="Ratner, L" uniqKey="Ratner L">L Ratner</name>
</author>
<author><name sortKey="Green, Pl" uniqKey="Green P">PL Green</name>
</author>
<author><name sortKey="Lairmore, Md" uniqKey="Lairmore M">MD Lairmore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miranda, S" uniqKey="Miranda S">S Miranda</name>
</author>
<author><name sortKey="Foncea, R" uniqKey="Foncea R">R Foncea</name>
</author>
<author><name sortKey="Guerrero, J" uniqKey="Guerrero J">J Guerrero</name>
</author>
<author><name sortKey="Leighton, F" uniqKey="Leighton F">F Leighton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Hc" uniqKey="Lee H">HC Lee</name>
</author>
<author><name sortKey="Yin, Ph" uniqKey="Yin P">PH Yin</name>
</author>
<author><name sortKey="Lu, Cy" uniqKey="Lu C">CY Lu</name>
</author>
<author><name sortKey="Chi, Cw" uniqKey="Chi C">CW Chi</name>
</author>
<author><name sortKey="Wei, Yh" uniqKey="Wei Y">YH Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suliman, Hb" uniqKey="Suliman H">HB Suliman</name>
</author>
<author><name sortKey="Carraway, Ms" uniqKey="Carraway M">MS Carraway</name>
</author>
<author><name sortKey="Welty Wolf, Ke" uniqKey="Welty Wolf K">KE Welty-Wolf</name>
</author>
<author><name sortKey="Whorton, Ar" uniqKey="Whorton A">AR Whorton</name>
</author>
<author><name sortKey="Piantados, Ca" uniqKey="Piantados C">CA Piantados</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Lee, Kc" uniqKey="Lee K">KC Lee</name>
</author>
<author><name sortKey="Ng, Wf" uniqKey="Ng W">WF Ng</name>
</author>
<author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name>
</author>
<author><name sortKey="Leung, Cy" uniqKey="Leung C">CY Leung</name>
</author>
<author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name>
</author>
<author><name sortKey="Hui, Pk" uniqKey="Hui P">PK Hui</name>
</author>
<author><name sortKey="Mak, Kl" uniqKey="Mak K">KL Mak</name>
</author>
<author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name>
</author>
<author><name sortKey="Yan, Kw" uniqKey="Yan K">KW Yan</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Tsang, Nc" uniqKey="Tsang N">NC Tsang</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
<author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
<author><name sortKey="Geng, J" uniqKey="Geng J">J Geng</name>
</author>
<author><name sortKey="Han, H" uniqKey="Han H">H Han</name>
</author>
<author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Kang, W" uniqKey="Kang W">W Kang</name>
</author>
<author><name sortKey="Weng, D" uniqKey="Weng D">D Weng</name>
</author>
<author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name>
</author>
<author><name sortKey="Wu, D" uniqKey="Wu D">D Wu</name>
</author>
<author><name sortKey="He, L" uniqKey="He L">L He</name>
</author>
<author><name sortKey="Yao, K" uniqKey="Yao K">K Yao</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rabilloud, T" uniqKey="Rabilloud T">T Rabilloud</name>
</author>
<author><name sortKey="Heller, M" uniqKey="Heller M">M Heller</name>
</author>
<author><name sortKey="Gasnier, F" uniqKey="Gasnier F">F Gasnier</name>
</author>
<author><name sortKey="Luche, S" uniqKey="Luche S">S Luche</name>
</author>
<author><name sortKey="Rey, C" uniqKey="Rey C">C Rey</name>
</author>
<author><name sortKey="Aebersold, R" uniqKey="Aebersold R">R Aebersold</name>
</author>
<author><name sortKey="Benahmed, M" uniqKey="Benahmed M">M Benahmed</name>
</author>
<author><name sortKey="Louisot, P" uniqKey="Louisot P">P Louisot</name>
</author>
<author><name sortKey="Lunardi, J" uniqKey="Lunardi J">J Lunardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pham, Cg" uniqKey="Pham C">CG Pham</name>
</author>
<author><name sortKey="Bubici, C" uniqKey="Bubici C">C Bubici</name>
</author>
<author><name sortKey="Zazzeroni, F" uniqKey="Zazzeroni F">F Zazzeroni</name>
</author>
<author><name sortKey="Papa, S" uniqKey="Papa S">S Papa</name>
</author>
<author><name sortKey="Jones, J" uniqKey="Jones J">J Jones</name>
</author>
<author><name sortKey="Alvarez, K" uniqKey="Alvarez K">K Alvarez</name>
</author>
<author><name sortKey="Jayawardena, S" uniqKey="Jayawardena S">S Jayawardena</name>
</author>
<author><name sortKey="De Smaele, E" uniqKey="De Smaele E">E De Smaele</name>
</author>
<author><name sortKey="Cong, R" uniqKey="Cong R">R Cong</name>
</author>
<author><name sortKey="Beaumont, C" uniqKey="Beaumont C">C Beaumont</name>
</author>
<author><name sortKey="Torti, Fm" uniqKey="Torti F">FM Torti</name>
</author>
<author><name sortKey="Torti, Sv" uniqKey="Torti S">SV Torti</name>
</author>
<author><name sortKey="Franzoso, G" uniqKey="Franzoso G">G Franzoso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reghunathan, R" uniqKey="Reghunathan R">R Reghunathan</name>
</author>
<author><name sortKey="Jayapal, M" uniqKey="Jayapal M">M Jayapal</name>
</author>
<author><name sortKey="Hsu, Ly" uniqKey="Hsu L">LY Hsu</name>
</author>
<author><name sortKey="Chng, Hh" uniqKey="Chng H">HH Chng</name>
</author>
<author><name sortKey="Tai, D" uniqKey="Tai D">D Tai</name>
</author>
<author><name sortKey="Leung, Bp" uniqKey="Leung B">BP Leung</name>
</author>
<author><name sortKey="Melendez, Aj" uniqKey="Melendez A">AJ Melendez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rao, Gn" uniqKey="Rao G">GN Rao</name>
</author>
<author><name sortKey="Berk, Bc" uniqKey="Berk B">BC Berk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name>
</author>
<author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name>
</author>
<author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name>
</author>
<author><name sortKey="Gao, H" uniqKey="Gao H">H Gao</name>
</author>
<author><name sortKey="Guo, F" uniqKey="Guo F">F Guo</name>
</author>
<author><name sortKey="Guan, B" uniqKey="Guan B">B Guan</name>
</author>
<author><name sortKey="Huan, Y" uniqKey="Huan Y">Y Huan</name>
</author>
<author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
<author><name sortKey="Bao, L" uniqKey="Bao L">L Bao</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Liu, G" uniqKey="Liu G">G Liu</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Chappell, M" uniqKey="Chappell M">M Chappell</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Zheng, D" uniqKey="Zheng D">D Zheng</name>
</author>
<author><name sortKey="Leibbrandt, A" uniqKey="Leibbrandt A">A Leibbrandt</name>
</author>
<author><name sortKey="Wada, T" uniqKey="Wada T">T Wada</name>
</author>
<author><name sortKey="Slutsky, As" uniqKey="Slutsky A">AS Slutsky</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name>
</author>
<author><name sortKey="Qin, C" uniqKey="Qin C">C Qin</name>
</author>
<author><name sortKey="Jiang, C" uniqKey="Jiang C">C Jiang</name>
</author>
<author><name sortKey="Penninger, Jm" uniqKey="Penninger J">JM Penninger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name>
</author>
<author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name>
</author>
<author><name sortKey="Ohlemeyer, C" uniqKey="Ohlemeyer C">C Ohlemeyer</name>
</author>
<author><name sortKey="Roos, D" uniqKey="Roos D">D Roos</name>
</author>
<author><name sortKey="Niessen, H" uniqKey="Niessen H">H Niessen</name>
</author>
<author><name sortKey="Kottgen, E" uniqKey="Kottgen E">E Kottgen</name>
</author>
<author><name sortKey="Gessner, R" uniqKey="Gessner R">R Gessner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, R" uniqKey="He R">R He</name>
</author>
<author><name sortKey="Leeson, A" uniqKey="Leeson A">A Leeson</name>
</author>
<author><name sortKey="Andonov, A" uniqKey="Andonov A">A Andonov</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name>
</author>
<author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name>
</author>
<author><name sortKey="Osiowy, C" uniqKey="Osiowy C">C Osiowy</name>
</author>
<author><name sortKey="Dobie, F" uniqKey="Dobie F">F Dobie</name>
</author>
<author><name sortKey="Cutts, T" uniqKey="Cutts T">T Cutts</name>
</author>
<author><name sortKey="Ballantine, M" uniqKey="Ballantine M">M Ballantine</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forrest, Ms" uniqKey="Forrest M">MS Forrest</name>
</author>
<author><name sortKey="Lan, Q" uniqKey="Lan Q">Q Lan</name>
</author>
<author><name sortKey="Hubbard, Ae" uniqKey="Hubbard A">AE Hubbard</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Vermeulen, R" uniqKey="Vermeulen R">R Vermeulen</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name>
</author>
<author><name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author><name sortKey="Wu, Yy" uniqKey="Wu Y">YY Wu</name>
</author>
<author><name sortKey="Shen, M" uniqKey="Shen M">M Shen</name>
</author>
<author><name sortKey="Yin, S" uniqKey="Yin S">S Yin</name>
</author>
<author><name sortKey="Chanock, Sj" uniqKey="Chanock S">SJ Chanock</name>
</author>
<author><name sortKey="Rothman, N" uniqKey="Rothman N">N Rothman</name>
</author>
<author><name sortKey="Smith, Mt" uniqKey="Smith M">MT Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sheets, P" uniqKey="Sheets P">P Sheets</name>
</author>
<author><name sortKey="Carlson, G" uniqKey="Carlson G">G Carlson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rana, Sv" uniqKey="Rana S">SV Rana</name>
</author>
<author><name sortKey="Verma, Y" uniqKey="Verma Y">Y Verma</name>
</author>
</analytic>
</biblStruct>
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