Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
Identifieur interne : 001018 ( Pmc/Checkpoint ); précédent : 001017; suivant : 001019Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
Auteurs : Hongwei Shao [République populaire de Chine] ; Dongming Lan [République populaire de Chine] ; Zhaohui Duan [République populaire de Chine] ; Zehuan Liu [République populaire de Chine] ; Jun Min [République populaire de Chine] ; Lichun Zhang [République populaire de Chine] ; Jian Huang [République populaire de Chine] ; Jing Su [République populaire de Chine] ; Shangwu Chen [République populaire de Chine] ; Anlong Xu [République populaire de Chine]Source :
- Journal of Clinical Immunology [ 0271-9142 ] ; 2006.
Abstract
The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV
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DOI: 10.1007/s10875-006-9046-y
PubMed: 17024565
PubMed Central: 7086694
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R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>510275 Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Lan, Dongming" sort="Lan, Dongming" uniqKey="Lan D" first="Dongming" last="Lan">Dongming Lan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id><institution-id institution-id-type="ISNI">000000012360039X</institution-id><institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution><institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution></institution-wrap>510275 Guangzhou, P. R. 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China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>510275 Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id><institution-id institution-id-type="ISNI">000000012360039X</institution-id><institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution><institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution></institution-wrap>510275 Guangzhou, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>510275 Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id><institution-id institution-id-type="ISNI">000000012360039X</institution-id><institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution><institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution></institution-wrap>510275 Guangzhou, P. R. China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>510275 Guangzhou</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Clinical Immunology</title><idno type="ISSN">0271-9142</idno><idno type="eISSN">1573-2592</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV <italic>in vivo</italic>. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yam, Lyc" uniqKey="Yam L">LYC Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name></author><author><name sortKey="Yee, Wks" uniqKey="Yee W">WKS Yee</name></author><author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name></author><author><name sortKey="Cheung, Mt" uniqKey="Cheung M">MT Cheung</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Immunol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Immunol</journal-id><journal-title-group><journal-title>Journal of Clinical Immunology</journal-title></journal-title-group><issn pub-type="ppub">0271-9142</issn><issn pub-type="epub">1573-2592</issn><publisher><publisher-name>Kluwer Academic Publishers-Plenum Publishers</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17024565</article-id><article-id pub-id-type="pmc">7086694</article-id><article-id pub-id-type="publisher-id">9046</article-id><article-id pub-id-type="doi">10.1007/s10875-006-9046-y</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>SHAO</surname><given-names>HONGWEI</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>LAN</surname><given-names>DONGMING</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>DUAN</surname><given-names>ZHAOHUI</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>LIU</surname><given-names>ZEHUAN</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>MIN</surname><given-names>JUN</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>ZHANG</surname><given-names>LICHUN</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>HUANG</surname><given-names>JIAN</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>SU</surname><given-names>JING</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>CHEN</surname><given-names>SHANGWU</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>XU</surname><given-names>ANLONG</given-names></name><address><email>lssxal@mail.sysu.edu.cn</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id><institution-id institution-id-type="ISNI">000000012360039X</institution-id><institution>State Key Laboratory of Biocontrol, Department of Biochemistry,</institution><institution>College of Life Sciences, Sun Yat-sen (Zhongshan) University,</institution></institution-wrap>510275 Guangzhou, P. R. China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.12981.33</institution-id><institution-id institution-id-type="ISNI">000000012360039X</institution-id><institution>The Second Affiliated Hospital, Sun Yat-sen (Zhongshan) University,</institution></institution-wrap>510120 Guangzhou, P. R. China</aff></contrib-group><pub-date pub-type="epub"><day>6</day><month>10</month><year>2006</year></pub-date><pub-date pub-type="ppub"><year>2006</year></pub-date><volume>26</volume><issue>6</issue><fpage>546</fpage><lpage>554</lpage><history><date date-type="received"><day>30</day><month>5</month><year>2006</year></date><date date-type="accepted"><day>8</day><month>9</month><year>2006</year></date></history><permissions><copyright-statement>© Springer Science+Business Media, LLC 2006</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV <italic>in vivo</italic>. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.</p></abstract><kwd-group xml:lang="en"><title>KEY WORDS</title><kwd>Severe acute respiratory syndrome</kwd><kwd>peripheral blood mononuclear cell</kwd><kwd>suppression subtractive hybridization</kwd><kwd>mitochondria</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media, LLC 2006</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Shao, Hongwei" sort="Shao, Hongwei" uniqKey="Shao H" first="Hongwei" last="Shao">Hongwei Shao</name></noRegion><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name><name sortKey="Duan, Zhaohui" sort="Duan, Zhaohui" uniqKey="Duan Z" first="Zhaohui" last="Duan">Zhaohui Duan</name><name sortKey="Huang, Jian" sort="Huang, Jian" uniqKey="Huang J" first="Jian" last="Huang">Jian Huang</name><name sortKey="Lan, Dongming" sort="Lan, Dongming" uniqKey="Lan D" first="Dongming" last="Lan">Dongming Lan</name><name sortKey="Liu, Zehuan" sort="Liu, Zehuan" uniqKey="Liu Z" first="Zehuan" last="Liu">Zehuan Liu</name><name sortKey="Min, Jun" sort="Min, Jun" uniqKey="Min J" first="Jun" last="Min">Jun Min</name><name sortKey="Su, Jing" sort="Su, Jing" uniqKey="Su J" first="Jing" last="Su">Jing Su</name><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name><name sortKey="Zhang, Lichun" sort="Zhang, Lichun" uniqKey="Zhang L" first="Lichun" last="Zhang">Lichun Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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