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Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients.

Identifieur interne : 001F34 ( PubMed/Checkpoint ); précédent : 001F33; suivant : 001F35

Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients.

Auteurs : Hongwei Shao [République populaire de Chine] ; Dongming Lan ; Zhaohui Duan ; Zehuan Liu ; Jun Min ; Lichun Zhang ; Jian Huang ; Jing Su ; Shangwu Chen ; Anlong Xu

Source :

Journal of clinical immunology [ 0271-9142 ] ; 2006.

RBID : pubmed:17024565

Descripteurs français

English descriptors

KwdEn :
- Adult, DNA, Mitochondrial (analysis), Female, Gene Expression Profiling, Genes, Mitochondrial, Humans, In Vitro Techniques, Leukocytes, Mononuclear (metabolism), Leukocytes, Mononuclear (virology), Microscopy, Electron, Microscopy, Electron, Transmission, Nucleic Acid Hybridization, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (metabolism), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Up-Regulation.
MESH :
- chemical , analysis : DNA, Mitochondrial.
- metabolism : Leukocytes, Mononuclear, SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Leukocytes, Mononuclear, Severe Acute Respiratory Syndrome.
- Adult, Female, Gene Expression Profiling, Genes, Mitochondrial, Humans, In Vitro Techniques, Microscopy, Electron, Microscopy, Electron, Transmission, Nucleic Acid Hybridization, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation.

Abstract

The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.

DOI: 10.1007/s10875-006-9046-y
PubMed: 17024565

Affiliations:

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pubmed:17024565

Le document en format XML

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<front><div type="abstract" xml:lang="en">The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.</div>
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Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients.

Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients.

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