A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
Identifieur interne : 004E83 ( Main/Exploration ); précédent : 004E82; suivant : 004E84A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV
Auteurs : John S. Oxford [Royaume-Uni] ; Robert Lambkin [Royaume-Uni] ; Iain Gibb [Royaume-Uni] ; Shobana Balasingam [Royaume-Uni] ; Charlotte Chan [Royaume-Uni] ; Andrew Catchpole [Royaume-Uni]Source :
- Antiviral chemistry & chemotherapy [ 0956-3202 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Alcools benzyliques, Antiviraux, Crésols.
- Pascal (Inist)
- Adenoviridae, Association médicamenteuse, Formes posologiques, Humains, Oropharynx, Alcool, Antiviral, Rhinovirus, Virus de la grippe A, Virus du SRAS, Virus respiratoire syncytial humain, Virus respiratoires syncytiaux, Voie respiratoire, Virus grippal A, Syndrome respiratoire aigu sévère, Grippe A, Rhinovirus, Forme pharmaceutique, Amylmétacrésol, Dichlorobenzyl Alcool.
- Wicri :
- topic : Alcool.
English descriptors
- KwdEn :
- Adenoviridae (drug effects), Alcohol, Amylmetacresol, Antiviral, Antiviral Agents (pharmacology), Benzyl Alcohols (pharmacology), Cresols (pharmacology), Dosage Forms, Dosage form, Drug Combinations, Human respiratory syncytial virus, Humans, Influenza A, Influenza A virus, Influenza A virus (drug effects), Oropharynx, Respiratory Syncytial Viruses (drug effects), Respiratory tract, Rhinovirus, Rhinovirus (drug effects), SARS Virus (drug effects), Severe acute respiratory syndrome.
- MESH :
- chemical , pharmacology : Antiviral Agents, Benzyl Alcohols, Cresols.
- drug effects : Adenoviridae, Influenza A virus, Respiratory Syncytial Viruses, Rhinovirus, SARS Virus.
- chemical : Dosage Forms, Drug Combinations, Humans.
Abstract
A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log10 TCID50 was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000657
- to stream PascalFrancis, to step Curation: 000333
- to stream PascalFrancis, to step Checkpoint: 000716
- to stream Main, to step Merge: 005236
- to stream PubMed, to step Corpus: 002746
- to stream PubMed, to step Curation: 002746
- to stream PubMed, to step Checkpoint: 002849
- to stream Ncbi, to step Merge: 000F41
- to stream Ncbi, to step Curation: 000F41
- to stream Ncbi, to step Checkpoint: 000F41
- to stream Main, to step Merge: 004C69
- to stream Main, to step Curation: 004E83
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV</title>
<author><name sortKey="Oxford, John S" sort="Oxford, John S" uniqKey="Oxford J" first="John S." last="Oxford">John S. Oxford</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambkin, Robert" sort="Lambkin, Robert" uniqKey="Lambkin R" first="Robert" last="Lambkin">Robert Lambkin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gibb, Iain" sort="Gibb, Iain" uniqKey="Gibb I" first="Iain" last="Gibb">Iain Gibb</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Boots Healthcare International Ltd, Product Development (Healthcare)</s1>
<s2>Nottingham</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Nottingham</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balasingam, Shobana" sort="Balasingam, Shobana" uniqKey="Balasingam S" first="Shobana" last="Balasingam">Shobana Balasingam</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Charlotte" sort="Chan, Charlotte" uniqKey="Chan C" first="Charlotte" last="Chan">Charlotte Chan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Catchpole, Andrew" sort="Catchpole, Andrew" uniqKey="Catchpole A" first="Andrew" last="Catchpole">Andrew Catchpole</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0281109</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0281109 INIST</idno>
<idno type="RBID">Pascal:05-0281109</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000657</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000333</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000716</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000716</idno>
<idno type="wicri:doubleKey">0956-3202:2005:Oxford J:a:throat:lozenge</idno>
<idno type="wicri:Area/Main/Merge">005236</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:15889535</idno>
<idno type="wicri:Area/PubMed/Corpus">002746</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002746</idno>
<idno type="wicri:Area/PubMed/Curation">002746</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002746</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002849</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002849</idno>
<idno type="wicri:Area/Ncbi/Merge">000F41</idno>
<idno type="wicri:Area/Ncbi/Curation">000F41</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F41</idno>
<idno type="wicri:doubleKey">0956-3202:2005:Oxford J:a:throat:lozenge</idno>
<idno type="wicri:Area/Main/Merge">004C69</idno>
<idno type="wicri:Area/Main/Curation">004E83</idno>
<idno type="wicri:Area/Main/Exploration">004E83</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV</title>
<author><name sortKey="Oxford, John S" sort="Oxford, John S" uniqKey="Oxford J" first="John S." last="Oxford">John S. Oxford</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambkin, Robert" sort="Lambkin, Robert" uniqKey="Lambkin R" first="Robert" last="Lambkin">Robert Lambkin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gibb, Iain" sort="Gibb, Iain" uniqKey="Gibb I" first="Iain" last="Gibb">Iain Gibb</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Boots Healthcare International Ltd, Product Development (Healthcare)</s1>
<s2>Nottingham</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Nottingham</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Balasingam, Shobana" sort="Balasingam, Shobana" uniqKey="Balasingam S" first="Shobana" last="Balasingam">Shobana Balasingam</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Charlotte" sort="Chan, Charlotte" uniqKey="Chan C" first="Charlotte" last="Chan">Charlotte Chan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Catchpole, Andrew" sort="Catchpole, Andrew" uniqKey="Catchpole A" first="Andrew" last="Catchpole">Andrew Catchpole</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Retroscreen Virology Ltd, Institute of Cell & Molecular Sciences, Barts & the Royal London, Queen Mary's School of Medicine and Dentistry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Antiviral chemistry & chemotherapy</title>
<title level="j" type="abbreviated">Antivir. chem. chemother.</title>
<idno type="ISSN">0956-3202</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral chemistry & chemotherapy</title>
<title level="j" type="abbreviated">Antivir. chem. chemother.</title>
<idno type="ISSN">0956-3202</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (drug effects)</term>
<term>Alcohol</term>
<term>Amylmetacresol</term>
<term>Antiviral</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Benzyl Alcohols (pharmacology)</term>
<term>Cresols (pharmacology)</term>
<term>Dosage Forms</term>
<term>Dosage form</term>
<term>Drug Combinations</term>
<term>Human respiratory syncytial virus</term>
<term>Humans</term>
<term>Influenza A</term>
<term>Influenza A virus</term>
<term>Influenza A virus (drug effects)</term>
<term>Oropharynx</term>
<term>Respiratory Syncytial Viruses (drug effects)</term>
<term>Respiratory tract</term>
<term>Rhinovirus</term>
<term>Rhinovirus (drug effects)</term>
<term>SARS Virus (drug effects)</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae ()</term>
<term>Alcools benzyliques (pharmacologie)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Association médicamenteuse</term>
<term>Crésols (pharmacologie)</term>
<term>Formes posologiques</term>
<term>Humains</term>
<term>Rhinovirus ()</term>
<term>Virus de la grippe A ()</term>
<term>Virus du SRAS ()</term>
<term>Virus respiratoires syncytiaux ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Benzyl Alcohols</term>
<term>Cresols</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Adenoviridae</term>
<term>Influenza A virus</term>
<term>Respiratory Syncytial Viruses</term>
<term>Rhinovirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Alcools benzyliques</term>
<term>Antiviraux</term>
<term>Crésols</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dosage Forms</term>
<term>Drug Combinations</term>
<term>Humans</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adenoviridae</term>
<term>Association médicamenteuse</term>
<term>Formes posologiques</term>
<term>Humains</term>
<term>Oropharynx</term>
<term>Alcool</term>
<term>Antiviral</term>
<term>Rhinovirus</term>
<term>Virus de la grippe A</term>
<term>Virus du SRAS</term>
<term>Virus respiratoire syncytial humain</term>
<term>Virus respiratoires syncytiaux</term>
<term>Voie respiratoire</term>
<term>Virus grippal A</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Grippe A</term>
<term>Rhinovirus</term>
<term>Forme pharmaceutique</term>
<term>Amylmétacrésol</term>
<term>Dichlorobenzyl Alcool</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Alcool</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A potent virucidal mixture containing amyl metacresol and dichlorobenzyl alcohol at low pH inactivated enveloped respiratory viruses influenza A, respiratory synctial virus (RSV) and severe acute respiratory syndrome coronavirus (SARS-CoV) but not viruses with icosahedral symmetry, such as adenoviruses or rhinoviruses. A titre of approximately 3.5 log<sub>10</sub>
TCID<sub>50</sub>
was reduced to below the level of detection within two minutes. Electron microscopy of purified influenza A virus showed extensive clumping and morphological changes in spike configuration after contact with the virucidal mixture, but no overt destruction of the viral membrane. We conclude that, formulated as a lozenge, the mixture could have significant effects in reducing the infectivity of certain infectious viruses in the throat and presumably in cough droplets, thus reducing, theoretically, opportunities for person-to-person transmission.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Oxford, John S" sort="Oxford, John S" uniqKey="Oxford J" first="John S." last="Oxford">John S. Oxford</name>
</region>
<name sortKey="Balasingam, Shobana" sort="Balasingam, Shobana" uniqKey="Balasingam S" first="Shobana" last="Balasingam">Shobana Balasingam</name>
<name sortKey="Catchpole, Andrew" sort="Catchpole, Andrew" uniqKey="Catchpole A" first="Andrew" last="Catchpole">Andrew Catchpole</name>
<name sortKey="Chan, Charlotte" sort="Chan, Charlotte" uniqKey="Chan C" first="Charlotte" last="Chan">Charlotte Chan</name>
<name sortKey="Gibb, Iain" sort="Gibb, Iain" uniqKey="Gibb I" first="Iain" last="Gibb">Iain Gibb</name>
<name sortKey="Lambkin, Robert" sort="Lambkin, Robert" uniqKey="Lambkin R" first="Robert" last="Lambkin">Robert Lambkin</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004E83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004E83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:05-0281109 |texte= A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |