Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation
Identifieur interne : 000E43 ( Ncbi/Checkpoint ); précédent : 000E42; suivant : 000E44Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation
Auteurs : Cathalijn H. C. Leenaars [Pays-Bas] ; Ruud N. J. M. A. Joosten [Pays-Bas] ; Allard Zwart [Pays-Bas] ; Hans Sandberg [Pays-Bas] ; Emma Ruimschotel [Pays-Bas] ; Maaike A. J. Hanegraaf [Pays-Bas] ; Maurice Dematteis [France] ; Matthijs G. P. Feenstra [Pays-Bas] ; Eus J. W. Van Someren [Pays-Bas]Source :
- Sleep [ 0161-8105 ] ; 2012.
Abstract
Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.
Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.
Controlled laboratory settings.
15 male Wistar rats.
Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.
We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.
Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation.
Url:
DOI: 10.5665/sleep.1624
PubMed: 22294811
PubMed Central: 3250360
Affiliations:
- France, Pays-Bas
- Auvergne-Rhône-Alpes, Hollande-Septentrionale, Rhône-Alpes
- Amsterdam
- Université Joseph Fourier
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<author><name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
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<author><name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
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<author><name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
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<author><name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6">Department of Integrative Neurophysiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Integrative Neurophysiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Design:</title>
<p>Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Settings:</title>
<p>Controlled laboratory settings.</p>
</sec>
<sec><title>Participants:</title>
<p>15 male Wistar rats.</p>
</sec>
<sec><title>Measurements & Results:</title>
<p>Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.</p>
</sec>
<sec><title>Citation:</title>
<p>Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. <italic>SLEEP</italic>
2012;35(2):211-221.</p>
</sec>
</div>
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<name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
<name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
<name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
<name sortKey="Joosten, Ruud N J M A" sort="Joosten, Ruud N J M A" uniqKey="Joosten R" first="Ruud N. J. M. A." last="Joosten">Ruud N. J. M. A. Joosten</name>
<name sortKey="Ruimschotel, Emma" sort="Ruimschotel, Emma" uniqKey="Ruimschotel E" first="Emma" last="Ruimschotel">Emma Ruimschotel</name>
<name sortKey="Sandberg, Hans" sort="Sandberg, Hans" uniqKey="Sandberg H" first="Hans" last="Sandberg">Hans Sandberg</name>
<name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
<name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
<name sortKey="Zwart, Allard" sort="Zwart, Allard" uniqKey="Zwart A" first="Allard" last="Zwart">Allard Zwart</name>
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<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
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<name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
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