ParkinsonFranceV1, Ncbi, Merge, bibRecord, 000E43

Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

Identifieur interne : 000E43 ( Ncbi/Merge ); précédent : 000E42; suivant : 000E44

Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

Auteurs : Cathalijn H. C. Leenaars [Pays-Bas] ; Ruud N. J. M. A. Joosten [Pays-Bas] ; Allard Zwart [Pays-Bas] ; Hans Sandberg [Pays-Bas] ; Emma Ruimschotel [Pays-Bas] ; Maaike A. J. Hanegraaf [Pays-Bas] ; Maurice Dematteis [France] ; Matthijs G. P. Feenstra [Pays-Bas] ; Eus J. W. Van Someren [Pays-Bas]

Source :

Sleep [ 0161-8105 ] ; 2012.

RBID : PMC:3250360

Abstract

Study Objectives:

Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.

Design:

Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.

Settings:

Controlled laboratory settings.

Participants:

15 male Wistar rats.

Measurements & Results:

Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.

Conclusions:

We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.

Citation:

Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. SLEEP 2012;35(2):211-221.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250360

DOI: 10.5665/sleep.1624
PubMed: 22294811
PubMed Central: 3250360

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000560
to stream Pmc, to step Curation: 000557
to stream Pmc, to step Checkpoint: 000563

Links to Exploration step

PMC:3250360

Le document en format XML

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<author><name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
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<author><name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
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<author><name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
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<series><title level="j">Sleep</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Design:</title>
<p>Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Settings:</title>
<p>Controlled laboratory settings.</p>
</sec>
<sec><title>Participants:</title>
<p>15 male Wistar rats.</p>
</sec>
<sec><title>Measurements & Results:</title>
<p>Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.</p>
</sec>
<sec><title>Citation:</title>
<p>Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. <italic>SLEEP</italic>
 2012;35(2):211-221.</p>
</sec>
</div>
</front>
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</journal-meta>
<article-meta><article-id pub-id-type="pmid">22294811</article-id>
<article-id pub-id-type="pmc">3250360</article-id>
<article-id pub-id-type="doi">10.5665/sleep.1624</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Rat Performance and Sleep Deprivation vs Sleep Fragmentation</subject>
</subj-group>
</article-categories>
<title-group><article-title>Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Leenaars</surname>
<given-names>Cathalijn H.C.</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Joosten</surname>
<given-names>Ruud N.J.M.A.</given-names>
</name>
<degrees>BAS</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zwart</surname>
<given-names>Allard</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sandberg</surname>
<given-names>Hans</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruimschotel</surname>
<given-names>Emma</given-names>
</name>
<degrees>BSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hanegraaf</surname>
<given-names>Maaike A.J.</given-names>
</name>
<degrees>BSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dematteis</surname>
<given-names>Maurice</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feenstra</surname>
<given-names>Matthijs G.P.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Someren</surname>
<given-names>Eus J.W.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</aff>
<aff id="aff2"><label>2</label>
Université Joseph Fourier, Faculté de Médecine, Grenoble, F-38042, France</aff>
<aff id="aff3"><label>3</label>
INSERM U1042, F-38042, France</aff>
<aff id="aff4"><label>4</label>
CHU de Grenoble, Hôpital A. Michallon, Pôle Pluridisciplinaire de Médecine, Grenoble, F-38043, France</aff>
<aff id="aff5"><label>5</label>
Department of Neuromodulation of Behaviour, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</aff>
<aff id="aff6"><label>6</label>
Department of Integrative Neurophysiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, the Netherlands</aff>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to: C.H.C. Leenaars, <addr-line>Meibergdreef 47, 1105 BA Amsterdam, The Netherlands</addr-line>
<phone>+31-20-5665495</phone>
<fax>+31-20-5666121</fax>
<email>C.Leenaars@nin.knaw.nl</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>1</day>
<month>2</month>
<year>2012</year>
</pub-date>
<volume>35</volume>
<issue>2</issue>
<fpage>211</fpage>
<lpage>221</lpage>
<history><date date-type="received"><month>3</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><month>7</month>
<year>2011</year>
</date>
<date date-type="accepted"><month>8</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© 2012 Associated Professional Sleep Societies, LLC.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><sec><title>Study Objectives:</title>
<p>Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Design:</title>
<p>Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Settings:</title>
<p>Controlled laboratory settings.</p>
</sec>
<sec><title>Participants:</title>
<p>15 male Wistar rats.</p>
</sec>
<sec><title>Measurements & Results:</title>
<p>Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.</p>
</sec>
<sec><title>Citation:</title>
<p>Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. <italic>SLEEP</italic>
 2012;35(2):211-221.</p>
</sec>
</abstract>
<kwd-group><kwd>Task-switching</kwd>
<kwd>prefrontal cortex</kwd>
<kwd>sleep deprivation</kwd>
<kwd>sleep fragmentation</kwd>
<kwd>conditional discrimination</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>Pays-Bas</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Hollande-Septentrionale</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Amsterdam</li>
</settlement>
<orgName><li>Université Joseph Fourier</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Leenaars, Cathalijn H C" sort="Leenaars, Cathalijn H C" uniqKey="Leenaars C" first="Cathalijn H. C." last="Leenaars">Cathalijn H. C. Leenaars</name>
</region>
<name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
<name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
<name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
<name sortKey="Joosten, Ruud N J M A" sort="Joosten, Ruud N J M A" uniqKey="Joosten R" first="Ruud N. J. M. A." last="Joosten">Ruud N. J. M. A. Joosten</name>
<name sortKey="Ruimschotel, Emma" sort="Ruimschotel, Emma" uniqKey="Ruimschotel E" first="Emma" last="Ruimschotel">Emma Ruimschotel</name>
<name sortKey="Sandberg, Hans" sort="Sandberg, Hans" uniqKey="Sandberg H" first="Hans" last="Sandberg">Hans Sandberg</name>
<name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
<name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
<name sortKey="Zwart, Allard" sort="Zwart, Allard" uniqKey="Zwart A" first="Allard" last="Zwart">Allard Zwart</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
</region>
<name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
<name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
</country>
</tree>
</affiliations>
</record>

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Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

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