A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.
Identifieur interne : 000E42 ( Ncbi/Checkpoint ); précédent : 000E41; suivant : 000E43A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease.
Auteurs : H. Pouclet [France] ; T. Lebouvier ; E. Coron ; S B Des Varannes ; M. Neunlist ; P. DerkinderenSource :
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [ 1365-2982 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- pathology : Colon, Intestinal Mucosa, Lewy Bodies, Neurites, Parkinson Disease, Submucous Plexus.
- Adult, Aged, Female, Humans, Immunohistochemistry, Male, Microdissection, Middle Aged.
Abstract
Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson's disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.
DOI: 10.1111/j.1365-2982.2012.01887.x
PubMed: 22292943
Affiliations:
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pubmed:22292943Le document en format XML
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Pouclet</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U913, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T" last="Lebouvier">T. Lebouvier</name></author><author><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E" last="Coron">E. Coron</name></author><author><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S B" last="Des Varannes">S B Des Varannes</name></author><author><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M" last="Neunlist">M. Neunlist</name></author><author><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P" last="Derkinderen">P. Derkinderen</name></author></analytic><series><title level="j">Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society</title><idno type="eISSN">1365-2982</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Colon (pathology)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Intestinal Mucosa (pathology)</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Microdissection</term><term>Middle Aged</term><term>Neurites (pathology)</term><term>Parkinson Disease (pathology)</term><term>Submucous Plexus (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term><term>Intestinal Mucosa</term><term>Lewy Bodies</term><term>Neurites</term><term>Parkinson Disease</term><term>Submucous Plexus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Microdissection</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson's disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><noCountry><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E" last="Coron">E. Coron</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P" last="Derkinderen">P. Derkinderen</name><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S B" last="Des Varannes">S B Des Varannes</name><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T" last="Lebouvier">T. Lebouvier</name><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M" last="Neunlist">M. Neunlist</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H" last="Pouclet">H. Pouclet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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