Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation
Identifieur interne : 000560 ( Pmc/Corpus ); précédent : 000559; suivant : 000561Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation
Auteurs : Cathalijn H. C. Leenaars ; Ruud N. J. M. A. Joosten ; Allard Zwart ; Hans Sandberg ; Emma Ruimschotel ; Maaike A. J. Hanegraaf ; Maurice Dematteis ; Matthijs G. P. Feenstra ; Eus J. W. Van SomerenSource :
- Sleep [ 0161-8105 ] ; 2012.
Abstract
Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.
Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.
Controlled laboratory settings.
15 male Wistar rats.
Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.
We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.
Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation.
Url:
DOI: 10.5665/sleep.1624
PubMed: 22294811
PubMed Central: 3250360
Links to Exploration step
PMC:3250360Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation</title>
<author><name sortKey="Leenaars, Cathalijn H C" sort="Leenaars, Cathalijn H C" uniqKey="Leenaars C" first="Cathalijn H. C." last="Leenaars">Cathalijn H. C. Leenaars</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joosten, Ruud N J M A" sort="Joosten, Ruud N J M A" uniqKey="Joosten R" first="Ruud N. J. M. A." last="Joosten">Ruud N. J. M. A. Joosten</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zwart, Allard" sort="Zwart, Allard" uniqKey="Zwart A" first="Allard" last="Zwart">Allard Zwart</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sandberg, Hans" sort="Sandberg, Hans" uniqKey="Sandberg H" first="Hans" last="Sandberg">Hans Sandberg</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruimschotel, Emma" sort="Ruimschotel, Emma" uniqKey="Ruimschotel E" first="Emma" last="Ruimschotel">Emma Ruimschotel</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
<affiliation><nlm:aff id="aff2">Université Joseph Fourier, Faculté de Médecine, Grenoble, F-38042, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">INSERM U1042, F-38042, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">CHU de Grenoble, Hôpital A. Michallon, Pôle Pluridisciplinaire de Médecine, Grenoble, F-38043, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Department of Neuromodulation of Behaviour, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Department of Integrative Neurophysiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22294811</idno>
<idno type="pmc">3250360</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250360</idno>
<idno type="RBID">PMC:3250360</idno>
<idno type="doi">10.5665/sleep.1624</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000560</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000560</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation</title>
<author><name sortKey="Leenaars, Cathalijn H C" sort="Leenaars, Cathalijn H C" uniqKey="Leenaars C" first="Cathalijn H. C." last="Leenaars">Cathalijn H. C. Leenaars</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joosten, Ruud N J M A" sort="Joosten, Ruud N J M A" uniqKey="Joosten R" first="Ruud N. J. M. A." last="Joosten">Ruud N. J. M. A. Joosten</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zwart, Allard" sort="Zwart, Allard" uniqKey="Zwart A" first="Allard" last="Zwart">Allard Zwart</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sandberg, Hans" sort="Sandberg, Hans" uniqKey="Sandberg H" first="Hans" last="Sandberg">Hans Sandberg</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruimschotel, Emma" sort="Ruimschotel, Emma" uniqKey="Ruimschotel E" first="Emma" last="Ruimschotel">Emma Ruimschotel</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
<affiliation><nlm:aff id="aff2">Université Joseph Fourier, Faculté de Médecine, Grenoble, F-38042, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">INSERM U1042, F-38042, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">CHU de Grenoble, Hôpital A. Michallon, Pôle Pluridisciplinaire de Médecine, Grenoble, F-38043, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Department of Neuromodulation of Behaviour, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
<affiliation><nlm:aff id="aff1">Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff6">Department of Integrative Neurophysiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, the Netherlands</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
<idno type="eISSN">1550-9109</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Design:</title>
<p>Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Settings:</title>
<p>Controlled laboratory settings.</p>
</sec>
<sec><title>Participants:</title>
<p>15 male Wistar rats.</p>
</sec>
<sec><title>Measurements & Results:</title>
<p>Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.</p>
</sec>
<sec><title>Citation:</title>
<p>Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. <italic>SLEEP</italic>
2012;35(2):211-221.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id>
<journal-id journal-id-type="publisher-id">Sleep</journal-id>
<journal-title-group><journal-title>Sleep</journal-title>
</journal-title-group>
<issn pub-type="ppub">0161-8105</issn>
<issn pub-type="epub">1550-9109</issn>
<publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22294811</article-id>
<article-id pub-id-type="pmc">3250360</article-id>
<article-id pub-id-type="doi">10.5665/sleep.1624</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Rat Performance and Sleep Deprivation vs Sleep Fragmentation</subject>
</subj-group>
</article-categories>
<title-group><article-title>Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Leenaars</surname>
<given-names>Cathalijn H.C.</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Joosten</surname>
<given-names>Ruud N.J.M.A.</given-names>
</name>
<degrees>BAS</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zwart</surname>
<given-names>Allard</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sandberg</surname>
<given-names>Hans</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruimschotel</surname>
<given-names>Emma</given-names>
</name>
<degrees>BSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hanegraaf</surname>
<given-names>Maaike A.J.</given-names>
</name>
<degrees>BSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dematteis</surname>
<given-names>Maurice</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Feenstra</surname>
<given-names>Matthijs G.P.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Someren</surname>
<given-names>Eus J.W.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<aff id="aff1"><label>1</label>
Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</aff>
<aff id="aff2"><label>2</label>
Université Joseph Fourier, Faculté de Médecine, Grenoble, F-38042, France</aff>
<aff id="aff3"><label>3</label>
INSERM U1042, F-38042, France</aff>
<aff id="aff4"><label>4</label>
CHU de Grenoble, Hôpital A. Michallon, Pôle Pluridisciplinaire de Médecine, Grenoble, F-38043, France</aff>
<aff id="aff5"><label>5</label>
Department of Neuromodulation of Behaviour, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands</aff>
<aff id="aff6"><label>6</label>
Department of Integrative Neurophysiology, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, the Netherlands</aff>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to: C.H.C. Leenaars, <addr-line>Meibergdreef 47, 1105 BA Amsterdam, The Netherlands</addr-line>
<phone>+31-20-5665495</phone>
<fax>+31-20-5666121</fax>
<email>C.Leenaars@nin.knaw.nl</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>1</day>
<month>2</month>
<year>2012</year>
</pub-date>
<volume>35</volume>
<issue>2</issue>
<fpage>211</fpage>
<lpage>221</lpage>
<history><date date-type="received"><month>3</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><month>7</month>
<year>2011</year>
</date>
<date date-type="accepted"><month>8</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© 2012 Associated Professional Sleep Societies, LLC.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><sec><title>Study Objectives:</title>
<p>Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Design:</title>
<p>Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Settings:</title>
<p>Controlled laboratory settings.</p>
</sec>
<sec><title>Participants:</title>
<p>15 male Wistar rats.</p>
</sec>
<sec><title>Measurements & Results:</title>
<p>Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.</p>
</sec>
<sec><title>Citation:</title>
<p>Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. <italic>SLEEP</italic>
2012;35(2):211-221.</p>
</sec>
</abstract>
<kwd-group><kwd>Task-switching</kwd>
<kwd>prefrontal cortex</kwd>
<kwd>sleep deprivation</kwd>
<kwd>sleep fragmentation</kwd>
<kwd>conditional discrimination</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000560 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000560 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:3250360 |texte= Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:22294811" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |