Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
Identifieur interne : 001734 ( Main/Merge ); précédent : 001733; suivant : 001735Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease
Auteurs : Hélène Mollion [France] ; Peter Ford Dominey [France] ; Emmanuel Broussolle [France] ; Jocelyne Ventre-Dominey [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
English descriptors
- KwdEn :
- Adult, Aged, Deep Brain Stimulation (methods), Female, Humans, Male, Memory Disorders (etiology), Memory Disorders (therapy), Memory, Short-Term (physiology), Middle Aged, Motor Activity (physiology), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson's disease, Photic Stimulation (methods), Reaction Time, Subthalamic Nucleus (physiology), functional dissociation, motor execution, subthalamic nucleus stimulation, visual memory.
- MESH :
- complications : Parkinson Disease.
- etiology : Memory Disorders.
- methods : Deep Brain Stimulation, Photic Stimulation.
- physiology : Memory, Short-Term, Motor Activity, Subthalamic Nucleus.
- therapy : Memory Disorders, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Reaction Time.
Abstract
Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23769
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ISTEX:346192D8FA7FD958C858317FE5152B218F0891D8Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2019">2019</biblScope><biblScope unit="page" to="2025">2025</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">346192D8FA7FD958C858317FE5152B218F0891D8</idno><idno type="DOI">10.1002/mds.23769</idno><idno type="ArticleID">MDS23769</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (therapy)</term><term>Memory, Short-Term (physiology)</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Parkinson's disease</term><term>Photic Stimulation (methods)</term><term>Reaction Time</term><term>Subthalamic Nucleus (physiology)</term><term>functional dissociation</term><term>motor execution</term><term>subthalamic nucleus stimulation</term><term>visual memory</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term><term>Motor Activity</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Memory Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reaction Time</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.23769"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name></author><author><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:346192D8FA7FD958C858317FE5152B218F0891D8</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23769</idno><idno type="url">https://api.istex.fr/document/346192D8FA7FD958C858317FE5152B218F0891D8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001942</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001942</idno><idno type="wicri:Area/Istex/Curation">001940</idno><idno type="wicri:Area/Istex/Checkpoint">000308</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000308</idno><idno type="wicri:doubleKey">0885-3185:2011:Mollion H:subthalamic:nucleus:stimulation</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dominey, Peter Ford" sort="Dominey, Peter Ford" uniqKey="Dominey P" first="Peter Ford" last="Dominey">Peter Ford Dominey</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Neurology Unit, Pierre Wertheimer Neurology Hospital, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Ventre Ominey, Jocelyne" sort="Ventre Ominey, Jocelyne" uniqKey="Ventre Ominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 846 Stem Cell and Brain Research Institute, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 846‐18, Avenue Doyen Lépine, 69675 Bron</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Bron</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2019">2019</biblScope><biblScope unit="page" to="2025">2025</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">346192D8FA7FD958C858317FE5152B218F0891D8</idno><idno type="DOI">10.1002/mds.23769</idno><idno type="ArticleID">MDS23769</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>functional dissociation</term><term>motor execution</term><term>subthalamic nucleus stimulation</term><term>visual memory</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color‐response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age‐matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing. © 2011 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation selectively improves motor and visual memory performance in Parkinson's disease.</title><author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name><affiliation wicri:level="3"><nlm:affiliation>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neuropsychology Unit, Pierre Wertheimer Neurology Hospital, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old 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type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (therapy)</term><term>Memory, Short-Term (physiology)</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Photic Stimulation (methods)</term><term>Reaction Time</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory, Short-Term</term><term>Motor Activity</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Memory Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reaction Time</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the treatment of Parkinson's disease via subthalamic stimulation yields remarkable improvements in motor symptoms, its effects on memory function are less clear. In this context, we previously demonstrated dissociable effects of levodopa therapy on parkinsonian performance in spatial and nonspatial visual working memory. Here we used the same protocol with an additional, purely motor task to investigate visual memory and motor performance in 2 groups of patients with Parkinson's disease with or without subthalamic stimulation. In each stimulation condition, subjects performed a simple motor task and 3 successive cognitive tasks: 1 conditional color-response association task and 2 visual (spatial and nonspatial) working memory tasks. The Parkinson's groups were compared with a control group of age-matched healthy subjects. Our principal results demonstrated that (1) in the motor task, stimulated patients were significantly improved with respect to nonstimulated patients and did not differ significantly from healthy controls, and (2) in the cognitive tasks, stimulated patients were significantly improved with respect to nonstimulated patients, but both remained significantly impaired when compared with healthy controls. These results demonstrate selective effects of subthalamic stimulation on parkinsonian disorders of motor and visual memory functions, with clear motor improvement for stimulated patients and a partial improvement for their visual memory processing.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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