ParkinsonFranceV1, Main, Merge, bibRecord, 001098

Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

Identifieur interne : 001098 ( Main/Merge ); précédent : 001097; suivant : 001099

Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

Auteurs : Cathalijn H. C. Leenaars [Pays-Bas] ; Ruud N. J. M. A. Joosten [Pays-Bas] ; Allard Zwart [Pays-Bas] ; Hans Sandberg [Pays-Bas] ; Emma Ruimschotel [Pays-Bas] ; Maaike A. J. Hanegraaf [Pays-Bas] ; Maurice Dematteis [France] ; Matthijs G. P. Feenstra [Pays-Bas] ; Eus J. W. Van Someren [Pays-Bas]

Source :

Sleep [ 0161-8105 ] ; 2012.

RBID : PMC:3250360

Abstract

Study Objectives:

Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.

Design:

Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.

Settings:

Controlled laboratory settings.

Participants:

15 male Wistar rats.

Measurements & Results:

Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.

Conclusions:

We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.

Citation:

Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. SLEEP 2012;35(2):211-221.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250360

DOI: 10.5665/sleep.1624
PubMed: 22294811
PubMed Central: 3250360

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PMC:3250360

Le document en format XML

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<author><name sortKey="Hanegraaf, Maaike A J" sort="Hanegraaf, Maaike A J" uniqKey="Hanegraaf M" first="Maaike A. J." last="Hanegraaf">Maaike A. J. Hanegraaf</name>
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<author><name sortKey="Dematteis, Maurice" sort="Dematteis, Maurice" uniqKey="Dematteis M" first="Maurice" last="Dematteis">Maurice Dematteis</name>
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<author><name sortKey="Feenstra, Matthijs G P" sort="Feenstra, Matthijs G P" uniqKey="Feenstra M" first="Matthijs G. P." last="Feenstra">Matthijs G. P. Feenstra</name>
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<author><name sortKey="Van Someren, Eus J W" sort="Van Someren, Eus J W" uniqKey="Van Someren E" first="Eus J. W." last="Van Someren">Eus J. W. Van Someren</name>
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<series><title level="j">Sleep</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title>
<p>Task-switching is an executive function involving the prefrontal cortex. Switching temporarily attenuates the speed and/or accuracy of performance, phenomena referred to as switch costs. In accordance with the idea that prefrontal function is particularly sensitive to sleep loss, switch-costs increase during prolonged waking in humans. It has been difficult to investigate the underlying neurobiological mechanisms because of the lack of a suitable animal model. Here, we introduce the first switch-task for rats and report the effects of sleep deprivation and inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Design:</title>
<p>Rats were trained to repeatedly switch between 2 stimulus-response associations, indicated by the presentation of a visual or an auditory stimulus. These stimulus-response associations were offered in blocks, and performance was compared for the first and fifth trials of each block. Performance was tested after exposure to 12 h of total sleep deprivation, sleep fragmentation, and their respective movement control conditions. Finally, it was tested after pharmacological inactivation of the medial prefrontal cortex.</p>
</sec>
<sec><title>Settings:</title>
<p>Controlled laboratory settings.</p>
</sec>
<sec><title>Participants:</title>
<p>15 male Wistar rats.</p>
</sec>
<sec><title>Measurements & Results:</title>
<p>Both accuracy and latency showed switch-costs at baseline. Twelve hours of total sleep deprivation, but not sleep fragmentation, impaired accuracy selectively on the switch-trials. Inactivation of the medial prefrontal cortex by local neuronal inactivation resulted in an overall decrease in accuracy.</p>
</sec>
<sec><title>Conclusions:</title>
<p>We developed and validated a switch-task that is sensitive to sleep deprivation. This introduces the possibility for in-depth investigations on the neurobiological mechanisms underlying executive impairments after sleep disturbance in a rat model.</p>
</sec>
<sec><title>Citation:</title>
<p>Leenaars CHC; Joosten RNJMA; Zwart A; Sandberg H; Ruimschotel E; Hanegraaf MAJ; Dematteis M; Feenstra MGP; van Someren EJW. Switch-task performance in rats is disturbed by 12 h of sleep deprivation but not by 12 h of sleep fragmentation. <italic>SLEEP</italic>
 2012;35(2):211-221.</p>
</sec>
</div>
</front>
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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:3250360
   |texte=   Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation
}}

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       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonFranceV1

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

Switch-Task Performance in Rats Is Disturbed by 12 h of Sleep Deprivation But Not by 12 h of Sleep Fragmentation

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