The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson's disease models
Identifieur interne : 001097 ( Main/Merge ); précédent : 001096; suivant : 001098The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson's disease models
Auteurs : S. Büttner [Autriche] ; L. Faes [Belgique] ; W N Reichelt [Autriche] ; F. Broeskamp [Autriche] ; L. Habernig [Autriche] ; S. Benke [Autriche] ; N. Kourtis [Grèce] ; D. Ruli [Autriche] ; D. Carmona-Gutierrez [Autriche] ; T. Eisenberg [Autriche] ; P. D'Hooge [Belgique] ; R. Ghillebert [Belgique] ; V. Franssens [Belgique] ; A. Harger [Autriche] ; T R Pieber [Autriche] ; P. Freudenberger [Autriche] ; G. Kroemer [France] ; S J Sigrist [Allemagne] ; J. Winderickx [Belgique] ; G. Callewaert [Belgique] ; N. Tavernarakis [Grèce] ; F. Madeo [Autriche]Source :
- Cell Death and Differentiation [ 1350-9047 ] ; 2012.
Abstract
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons, which arises from a yet elusive concurrence between genetic and environmental factors. The protein
Url:
DOI: 10.1038/cdd.2012.142
PubMed: 23154387
PubMed Central: 3569987
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000011
- to stream Pmc, to step Curation: 000011
- to stream Pmc, to step Checkpoint: 000562
- to stream Ncbi, to step Merge: 001013
- to stream Ncbi, to step Curation: 001013
- to stream Ncbi, to step Checkpoint: 001013
Links to Exploration step
PMC:3569987Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Ca<sup>2+</sup>/Mn<sup>2+</sup> ion-pump PMR1 links elevation of cytosolic Ca<sup>2+</sup> levels to <italic>α</italic>-synuclein toxicity in Parkinson's disease models</title><author><name sortKey="Buttner, S" sort="Buttner, S" uniqKey="Buttner S" first="S" last="Büttner">S. Büttner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Faes, L" sort="Faes, L" uniqKey="Faes L" first="L" last="Faes">L. Faes</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Research Group Neurodegeneration; Katholieke Universiteit Leuven Campus Kortrijk</institution>, Kortrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reichelt, W N" sort="Reichelt, W N" uniqKey="Reichelt W" first="W N" last="Reichelt">W N Reichelt</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broeskamp, F" sort="Broeskamp, F" uniqKey="Broeskamp F" first="F" last="Broeskamp">F. Broeskamp</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Habernig, L" sort="Habernig, L" uniqKey="Habernig L" first="L" last="Habernig">L. Habernig</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benke, S" sort="Benke, S" uniqKey="Benke S" first="S" last="Benke">S. Benke</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kourtis, N" sort="Kourtis, N" uniqKey="Kourtis N" first="N" last="Kourtis">N. Kourtis</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruli, D" sort="Ruli, D" uniqKey="Ruli D" first="D" last="Ruli">D. Ruli</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carmona Gutierrez, D" sort="Carmona Gutierrez, D" uniqKey="Carmona Gutierrez D" first="D" last="Carmona-Gutierrez">D. Carmona-Gutierrez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eisenberg, T" sort="Eisenberg, T" uniqKey="Eisenberg T" first="T" last="Eisenberg">T. Eisenberg</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Hooge, P" sort="D Hooge, P" uniqKey="D Hooge P" first="P" last="D'Hooge">P. D'Hooge</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Research Group Neurodegeneration; Katholieke Universiteit Leuven Campus Kortrijk</institution>, Kortrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghillebert, R" sort="Ghillebert, R" uniqKey="Ghillebert R" first="R" last="Ghillebert">R. Ghillebert</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franssens, V" sort="Franssens, V" uniqKey="Franssens V" first="V" last="Franssens">V. Franssens</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harger, A" sort="Harger, A" uniqKey="Harger A" first="A" last="Harger">A. Harger</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Internal Medicine, Medical University Graz</institution>, Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pieber, T R" sort="Pieber, T R" uniqKey="Pieber T" first="T R" last="Pieber">T R Pieber</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Internal Medicine, Medical University Graz</institution>, Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freudenberger, P" sort="Freudenberger, P" uniqKey="Freudenberger P" first="P" last="Freudenberger">P. Freudenberger</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>INSERM, U848</institution>, 94805 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Metabolomics Platform, Institut Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Centre de Recherche des Cordeliers</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sigrist, S J" sort="Sigrist, S J" uniqKey="Sigrist S" first="S J" last="Sigrist">S J Sigrist</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Winderickx, J" sort="Winderickx, J" uniqKey="Winderickx J" first="J" last="Winderickx">J. Winderickx</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Callewaert, G" sort="Callewaert, G" uniqKey="Callewaert G" first="G" last="Callewaert">G. Callewaert</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Research Group Neurodegeneration; Katholieke Universiteit Leuven Campus Kortrijk</institution>, Kortrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tavernarakis, N" sort="Tavernarakis, N" uniqKey="Tavernarakis N" first="N" last="Tavernarakis">N. Tavernarakis</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Madeo, F" sort="Madeo, F" uniqKey="Madeo F" first="F" last="Madeo">F. Madeo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23154387</idno><idno type="pmc">3569987</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569987</idno><idno type="RBID">PMC:3569987</idno><idno type="doi">10.1038/cdd.2012.142</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000011</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000011</idno><idno type="wicri:Area/Pmc/Curation">000011</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000011</idno><idno type="wicri:Area/Pmc/Checkpoint">000562</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000562</idno><idno type="wicri:Area/Ncbi/Merge">001013</idno><idno type="wicri:Area/Ncbi/Curation">001013</idno><idno type="wicri:Area/Ncbi/Checkpoint">001013</idno><idno type="wicri:Area/Main/Merge">001097</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Ca<sup>2+</sup>/Mn<sup>2+</sup> ion-pump PMR1 links elevation of cytosolic Ca<sup>2+</sup> levels to <italic>α</italic>-synuclein toxicity in Parkinson's disease models</title><author><name sortKey="Buttner, S" sort="Buttner, S" uniqKey="Buttner S" first="S" last="Büttner">S. Büttner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Faes, L" sort="Faes, L" uniqKey="Faes L" first="L" last="Faes">L. Faes</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Research Group Neurodegeneration; Katholieke Universiteit Leuven Campus Kortrijk</institution>, Kortrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reichelt, W N" sort="Reichelt, W N" uniqKey="Reichelt W" first="W N" last="Reichelt">W N Reichelt</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broeskamp, F" sort="Broeskamp, F" uniqKey="Broeskamp F" first="F" last="Broeskamp">F. Broeskamp</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Habernig, L" sort="Habernig, L" uniqKey="Habernig L" first="L" last="Habernig">L. Habernig</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benke, S" sort="Benke, S" uniqKey="Benke S" first="S" last="Benke">S. Benke</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kourtis, N" sort="Kourtis, N" uniqKey="Kourtis N" first="N" last="Kourtis">N. Kourtis</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ruli, D" sort="Ruli, D" uniqKey="Ruli D" first="D" last="Ruli">D. Ruli</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carmona Gutierrez, D" sort="Carmona Gutierrez, D" uniqKey="Carmona Gutierrez D" first="D" last="Carmona-Gutierrez">D. Carmona-Gutierrez</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eisenberg, T" sort="Eisenberg, T" uniqKey="Eisenberg T" first="T" last="Eisenberg">T. Eisenberg</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Hooge, P" sort="D Hooge, P" uniqKey="D Hooge P" first="P" last="D'Hooge">P. D'Hooge</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Research Group Neurodegeneration; Katholieke Universiteit Leuven Campus Kortrijk</institution>, Kortrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ghillebert, R" sort="Ghillebert, R" uniqKey="Ghillebert R" first="R" last="Ghillebert">R. Ghillebert</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franssens, V" sort="Franssens, V" uniqKey="Franssens V" first="V" last="Franssens">V. Franssens</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harger, A" sort="Harger, A" uniqKey="Harger A" first="A" last="Harger">A. Harger</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Internal Medicine, Medical University Graz</institution>, Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pieber, T R" sort="Pieber, T R" uniqKey="Pieber T" first="T R" last="Pieber">T R Pieber</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Internal Medicine, Medical University Graz</institution>, Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freudenberger, P" sort="Freudenberger, P" uniqKey="Freudenberger P" first="P" last="Freudenberger">P. Freudenberger</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, G" sort="Kroemer, G" uniqKey="Kroemer G" first="G" last="Kroemer">G. Kroemer</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>INSERM, U848</institution>, 94805 Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Metabolomics Platform, Institut Gustave Roussy</institution>, Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Centre de Recherche des Cordeliers</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sigrist, S J" sort="Sigrist, S J" uniqKey="Sigrist S" first="S J" last="Sigrist">S J Sigrist</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Winderickx, J" sort="Winderickx, J" uniqKey="Winderickx J" first="J" last="Winderickx">J. Winderickx</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Functional Biology; Katholieke Universiteit Leuven</institution>, Leuven,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Callewaert, G" sort="Callewaert, G" uniqKey="Callewaert G" first="G" last="Callewaert">G. Callewaert</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Research Group Neurodegeneration; Katholieke Universiteit Leuven Campus Kortrijk</institution>, Kortrijk,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tavernarakis, N" sort="Tavernarakis, N" uniqKey="Tavernarakis N" first="N" last="Tavernarakis">N. Tavernarakis</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Madeo, F" sort="Madeo, F" uniqKey="Madeo F" first="F" last="Madeo">F. Madeo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Death and Differentiation</title><idno type="ISSN">1350-9047</idno><idno type="eISSN">1476-5403</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons, which arises from a yet elusive concurrence between genetic and environmental factors. The protein <italic>α</italic>-synuclein (<italic>α</italic>Syn), the principle toxic effector in PD, has been shown to interfere with neuronal Ca<sup>2+</sup> fluxes, arguing for an involvement of deregulated Ca<sup>2+</sup> homeostasis in this neuronal demise. Here, we identify the Golgi-resident Ca<sup>2+</sup>/Mn<sup>2+</sup> ATPase PMR1 (plasma membrane-related Ca<sup>2+</sup>-ATPase 1) as a phylogenetically conserved mediator of <italic>α</italic>Syn-driven changes in Ca<sup>2+</sup> homeostasis and cytotoxicity. Expression of <italic>α</italic>Syn in yeast resulted in elevated cytosolic Ca<sup>2+</sup> levels and increased cell death, both of which could be inhibited by deletion of PMR1. Accordingly, absence of PMR1 prevented <italic>α</italic>Syn-induced loss of dopaminergic neurons in nematodes and flies. In addition, <italic>α</italic>Syn failed to compromise locomotion and survival of flies when PMR1 was absent. In conclusion, the <italic>α</italic>Syn-driven rise of cytosolic Ca<sup>2+</sup> levels is pivotal for its cytotoxicity and requires PMR1.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Spillantini, Mg" uniqKey="Spillantini M">MG Spillantini</name></author><author><name sortKey="Schmidt, Ml" uniqKey="Schmidt M">ML Schmidt</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Jakes, R" uniqKey="Jakes R">R Jakes</name></author><author><name sortKey="Goedert, M" uniqKey="Goedert M">M Goedert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruger, R" uniqKey="Kruger R">R Kruger</name></author><author><name sortKey="Kuhn, W" uniqKey="Kuhn W">W Kuhn</name></author><author><name sortKey="Muller, T" uniqKey="Muller T">T Müller</name></author><author><name sortKey="Woitalla, D" uniqKey="Woitalla D">D Woitalla</name></author><author><name sortKey="Graeber, M" uniqKey="Graeber M">M Graeber</name></author><author><name sortKey="Kosel, S" uniqKey="Kosel S">S Kösel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singleton, Ab" uniqKey="Singleton A">AB Singleton</name></author><author><name sortKey="Farrer, M" uniqKey="Farrer M">M Farrer</name></author><author><name sortKey="Johnson, J" uniqKey="Johnson J">J Johnson</name></author><author><name sortKey="Singleton, A" uniqKey="Singleton A">A Singleton</name></author><author><name sortKey="Hague, S" uniqKey="Hague S">S Hague</name></author><author><name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zarranz, Jj" uniqKey="Zarranz J">JJ Zarranz</name></author><author><name sortKey="Alegre, J" uniqKey="Alegre J">J Alegre</name></author><author><name sortKey="G Mez Esteban, Jc" uniqKey="G Mez Esteban J">JC Gómez-Esteban</name></author><author><name sortKey="Lezcano, E" uniqKey="Lezcano E">E Lezcano</name></author><author><name sortKey="Ros, R" uniqKey="Ros R">R Ros</name></author><author><name sortKey="Ampuero, I" uniqKey="Ampuero I">I Ampuero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrer, M" uniqKey="Farrer M">M Farrer</name></author><author><name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name></author><author><name sortKey="Forno, L" uniqKey="Forno L">L Forno</name></author><author><name sortKey="Lincoln, S" uniqKey="Lincoln S">S Lincoln</name></author><author><name sortKey="Wang, Ds" uniqKey="Wang D">DS Wang</name></author><author><name sortKey="Hulihan, M" uniqKey="Hulihan M">M Hulihan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polymeropoulos, Mh" uniqKey="Polymeropoulos M">MH Polymeropoulos</name></author><author><name sortKey="Lavedan, C" uniqKey="Lavedan C">C Lavedan</name></author><author><name sortKey="Leroy, E" uniqKey="Leroy E">E Leroy</name></author><author><name sortKey="Ide, Se" uniqKey="Ide S">SE Ide</name></author><author><name sortKey="Dehejia, A" uniqKey="Dehejia A">A Dehejia</name></author><author><name sortKey="Dutra, A" uniqKey="Dutra A">A Dutra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Cs" uniqKey="Chan C">CS Chan</name></author><author><name sortKey="Guzman, Jn" uniqKey="Guzman J">JN Guzman</name></author><author><name sortKey="Ilijic, E" uniqKey="Ilijic E">E Ilijic</name></author><author><name sortKey="Mercer, Jn" uniqKey="Mercer J">JN Mercer</name></author><author><name sortKey="Rick, C" uniqKey="Rick C">C Rick</name></author><author><name sortKey="Tkatch, T" uniqKey="Tkatch T">T Tkatch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cali, T" uniqKey="Cali T">T Calì</name></author><author><name sortKey="Ottolini, D" uniqKey="Ottolini D">D Ottolini</name></author><author><name sortKey="Brini, M" uniqKey="Brini M">M Brini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lowe, R" uniqKey="Lowe R">R Lowe</name></author><author><name sortKey="Pountney, Dl" uniqKey="Pountney D">DL Pountney</name></author><author><name sortKey="Jensen, Ph" uniqKey="Jensen P">PH Jensen</name></author><author><name sortKey="Gai, Wp" uniqKey="Gai W">WP Gai</name></author><author><name sortKey="Voelcker, Nh" uniqKey="Voelcker N">NH Voelcker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adamczyk, A" uniqKey="Adamczyk A">A Adamczyk</name></author><author><name sortKey="Strosznajder, Jb" uniqKey="Strosznajder J">JB Strosznajder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hettiarachchi, Nt" uniqKey="Hettiarachchi N">NT Hettiarachchi</name></author><author><name sortKey="Parker, A" uniqKey="Parker A">A Parker</name></author><author><name sortKey="Dallas, Ml" uniqKey="Dallas M">ML Dallas</name></author><author><name sortKey="Pennington, K" uniqKey="Pennington K">K Pennington</name></author><author><name sortKey="Hung, Cc" uniqKey="Hung C">CC Hung</name></author><author><name sortKey="Pearson, Ha" uniqKey="Pearson H">HA Pearson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danzer, Km" uniqKey="Danzer K">KM Danzer</name></author><author><name sortKey="Haasen, D" uniqKey="Haasen D">D Haasen</name></author><author><name sortKey="Karow, Ar" uniqKey="Karow A">AR Karow</name></author><author><name sortKey="Moussaud, S" uniqKey="Moussaud S">S Moussaud</name></author><author><name sortKey="Habeck, M" uniqKey="Habeck M">M Habeck</name></author><author><name sortKey="Giese, A" uniqKey="Giese A">A Giese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khurana, V" uniqKey="Khurana V">V Khurana</name></author><author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S Lindquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttner, S" uniqKey="Buttner S">S Büttner</name></author><author><name sortKey="Bitto, A" uniqKey="Bitto A">A Bitto</name></author><author><name sortKey="Ring, J" uniqKey="Ring J">J Ring</name></author><author><name sortKey="Augsten, M" uniqKey="Augsten M">M Augsten</name></author><author><name sortKey="Zabrocki, P" uniqKey="Zabrocki P">P Zabrocki</name></author><author><name sortKey="Eisenberg, T" uniqKey="Eisenberg T">T Eisenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Outeiro, Tf" uniqKey="Outeiro T">TF Outeiro</name></author><author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S Lindquist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, Aa" uniqKey="Cooper A">AA Cooper</name></author><author><name sortKey="Gitler, Ad" uniqKey="Gitler A">AD Gitler</name></author><author><name sortKey="Cashikar, A" uniqKey="Cashikar A">A Cashikar</name></author><author><name sortKey="Haynes, Cm" uniqKey="Haynes C">CM Haynes</name></author><author><name sortKey="Hill, Kj" uniqKey="Hill K">KJ Hill</name></author><author><name sortKey="Bhullar, B" uniqKey="Bhullar B">B Bhullar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zabrocki, P" uniqKey="Zabrocki P">P Zabrocki</name></author><author><name sortKey="Bastiaens, I" uniqKey="Bastiaens I">I Bastiaens</name></author><author><name sortKey="Delay, C" uniqKey="Delay C">C Delay</name></author><author><name sortKey="Bammens, T" uniqKey="Bammens T">T Bammens</name></author><author><name sortKey="Ghillebert, R" uniqKey="Ghillebert R">R Ghillebert</name></author><author><name sortKey="Pellens, K" uniqKey="Pellens K">K Pellens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ton, V K" uniqKey="Ton V">V-K Ton</name></author><author><name sortKey="Rao, R" uniqKey="Rao R">R Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cronin, Sr" uniqKey="Cronin S">SR Cronin</name></author><author><name sortKey="Rao, R" uniqKey="Rao R">R Rao</name></author><author><name sortKey="Hampton, Ry" uniqKey="Hampton R">RY Hampton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, J" uniqKey="Cui J">J Cui</name></author><author><name sortKey="Kaandorp, Ja" uniqKey="Kaandorp J">JA Kaandorp</name></author><author><name sortKey="Sloot, Pma" uniqKey="Sloot P">PMA Sloot</name></author><author><name sortKey="Lloyd, Cm" uniqKey="Lloyd C">CM Lloyd</name></author><author><name sortKey="Filatov, Mv" uniqKey="Filatov M">MV Filatov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abou Sleiman, Pm" uniqKey="Abou Sleiman P">PM Abou-Sleiman</name></author><author><name sortKey="Muqit, Mm" uniqKey="Muqit M">MM Muqit</name></author><author><name sortKey="Wood, Nw" uniqKey="Wood N">NW Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jomova, K" uniqKey="Jomova K">K Jomova</name></author><author><name sortKey="Vondrakova, D" uniqKey="Vondrakova D">D Vondrakova</name></author><author><name sortKey="Lawson, M" uniqKey="Lawson M">M Lawson</name></author><author><name sortKey="Valko, M" uniqKey="Valko M">M Valko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name></author><author><name sortKey="Gu, L" uniqKey="Gu L">L Gu</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berman, Ae" uniqKey="Berman A">AE Berman</name></author><author><name sortKey="Chan, Wy" uniqKey="Chan W">WY Chan</name></author><author><name sortKey="Brennan, Am" uniqKey="Brennan A">AM Brennan</name></author><author><name sortKey="Reyes, Rc" uniqKey="Reyes R">RC Reyes</name></author><author><name sortKey="Adler, Bl" uniqKey="Adler B">BL Adler</name></author><author><name sortKey="Suh, Sw" uniqKey="Suh S">SW Suh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, J" uniqKey="Clark J">J Clark</name></author><author><name sortKey="Clore, El" uniqKey="Clore E">EL Clore</name></author><author><name sortKey="Zheng, K" uniqKey="Zheng K">K Zheng</name></author><author><name sortKey="Adame, A" uniqKey="Adame A">A Adame</name></author><author><name sortKey="Masliah, E" uniqKey="Masliah E">E Masliah</name></author><author><name sortKey="Simon, Dk" uniqKey="Simon D">DK Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bagh, Mb" uniqKey="Bagh M">MB Bagh</name></author><author><name sortKey="Maiti, Ak" uniqKey="Maiti A">AK Maiti</name></author><author><name sortKey="Jana, S" uniqKey="Jana S">S Jana</name></author><author><name sortKey="Banerjee, K" uniqKey="Banerjee K">K Banerjee</name></author><author><name sortKey="Roy, A" uniqKey="Roy A">A Roy</name></author><author><name sortKey="Chakrabarti, S" uniqKey="Chakrabarti S">S Chakrabarti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yen, K" uniqKey="Yen K">K Yen</name></author><author><name sortKey="Gitsham, P" uniqKey="Gitsham P">P Gitsham</name></author><author><name sortKey="Wishart, J" uniqKey="Wishart J">J Wishart</name></author><author><name sortKey="Oliver, Sg" uniqKey="Oliver S">SG Oliver</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonilla, M" uniqKey="Bonilla M">M Bonilla</name></author><author><name sortKey="Nastase, Kk" uniqKey="Nastase K">KK Nastase</name></author><author><name sortKey="Cunningham, Kw" uniqKey="Cunningham K">KW Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miseta, A" uniqKey="Miseta A">A Miseta</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Kellermayer, R" uniqKey="Kellermayer R">R Kellermayer</name></author><author><name sortKey="Buckley, J" uniqKey="Buckley J">J Buckley</name></author><author><name sortKey="Bedwell, Dm" uniqKey="Bedwell D">DM Bedwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Dc" uniqKey="Martin D">DC Martin</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Mackin, Na" uniqKey="Mackin N">NA Mackin</name></author><author><name sortKey="Maldonado Baez, L" uniqKey="Maldonado Baez L">L Maldonado-Báez</name></author><author><name sortKey="Evangelista, Cc" uniqKey="Evangelista C">CC Evangelista</name></author><author><name sortKey="Beaudry, Vg" uniqKey="Beaudry V">VG Beaudry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Locke, Eg" uniqKey="Locke E">EG Locke</name></author><author><name sortKey="Bonilla, M" uniqKey="Bonilla M">M Bonilla</name></author><author><name sortKey="Liang, L" uniqKey="Liang L">L Liang</name></author><author><name sortKey="Takita, Y" uniqKey="Takita Y">Y Takita</name></author><author><name sortKey="Cunningham, Kw" uniqKey="Cunningham K">KW Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durr, G" uniqKey="Durr G">G Dürr</name></author><author><name sortKey="Strayle, J" uniqKey="Strayle J">J Strayle</name></author><author><name sortKey="Plemper, R" uniqKey="Plemper R">R Plemper</name></author><author><name sortKey="Elbs, S" uniqKey="Elbs S">S Elbs</name></author><author><name sortKey="Klee, Sk" uniqKey="Klee S">SK Klee</name></author><author><name sortKey="Catty, P" uniqKey="Catty P">P Catty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunningham, Kw" uniqKey="Cunningham K">KW Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ton, V K" uniqKey="Ton V">V-K Ton</name></author><author><name sortKey="Mandal, D" uniqKey="Mandal D">D Mandal</name></author><author><name sortKey="Vahadji, C" uniqKey="Vahadji C">C Vahadji</name></author><author><name sortKey="Rao, R" uniqKey="Rao R">R Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mandal, D" uniqKey="Mandal D">D Mandal</name></author><author><name sortKey="Woolf, Tb" uniqKey="Woolf T">TB Woolf</name></author><author><name sortKey="Rao, R" uniqKey="Rao R">R Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pal, Pk" uniqKey="Pal P">PK Pal</name></author><author><name sortKey="Samii, A" uniqKey="Samii A">A Samii</name></author><author><name sortKey="Calne, Db" uniqKey="Calne D">DB Calne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gitler, Ad" uniqKey="Gitler A">AD Gitler</name></author><author><name sortKey="Chesi, A" uniqKey="Chesi A">A Chesi</name></author><author><name sortKey="Geddie, Ml" uniqKey="Geddie M">ML Geddie</name></author><author><name sortKey="Strathearn, Ke" uniqKey="Strathearn K">KE Strathearn</name></author><author><name sortKey="Hamamichi, S" uniqKey="Hamamichi S">S Hamamichi</name></author><author><name sortKey="Hill, Kj" uniqKey="Hill K">KJ Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Covy, Jp" uniqKey="Covy J">JP Covy</name></author><author><name sortKey="Giasson, Bi" uniqKey="Giasson B">BI Giasson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Covy, Jp" uniqKey="Covy J">JP Covy</name></author><author><name sortKey="Waxman, Ea" uniqKey="Waxman E">EA Waxman</name></author><author><name sortKey="Giasson, Bi" uniqKey="Giasson B">BI Giasson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, J" uniqKey="Tan J">J Tan</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Chi, J" uniqKey="Chi J">J Chi</name></author><author><name sortKey="Hu, D" uniqKey="Hu D">D Hu</name></author><author><name sortKey="Pan, Q" uniqKey="Pan Q">Q Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settivari, R" uniqKey="Settivari R">R Settivari</name></author><author><name sortKey="Levora, J" uniqKey="Levora J">J Levora</name></author><author><name sortKey="Nass, R" uniqKey="Nass R">R Nass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Marchi, V" uniqKey="Marchi V">V Marchi</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Rao, R" uniqKey="Rao R">R Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakai, J" uniqKey="Nakai J">J Nakai</name></author><author><name sortKey="Ohkura, M" uniqKey="Ohkura M">M Ohkura</name></author><author><name sortKey="Imoto, K" uniqKey="Imoto K">K Imoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feany, Mb" uniqKey="Feany M">MB Feany</name></author><author><name sortKey="Bender, Ww" uniqKey="Bender W">WW Bender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orrenius, S" uniqKey="Orrenius S">S Orrenius</name></author><author><name sortKey="Zhivotovsky, B" uniqKey="Zhivotovsky B">B Zhivotovsky</name></author><author><name sortKey="Nicotera, P" uniqKey="Nicotera P">P Nicotera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wojda, U" uniqKey="Wojda U">U Wojda</name></author><author><name sortKey="Salinska, E" uniqKey="Salinska E">E Salinska</name></author><author><name sortKey="Kuznicki, J" uniqKey="Kuznicki J">J Kuznicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schapira, Ahv" uniqKey="Schapira A">AHV Schapira</name></author><author><name sortKey="Gegg, M" uniqKey="Gegg M">M Gegg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Protter, D" uniqKey="Protter D">D Protter</name></author><author><name sortKey="Lang, C" uniqKey="Lang C">C Lang</name></author><author><name sortKey="Cooper, Aa" uniqKey="Cooper A">AA Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamp, F" uniqKey="Kamp F">F Kamp</name></author><author><name sortKey="Exner, N" uniqKey="Exner N">N Exner</name></author><author><name sortKey="Lutz, Ak" uniqKey="Lutz A">AK Lutz</name></author><author><name sortKey="Wender, N" uniqKey="Wender N">N Wender</name></author><author><name sortKey="Hegermann, J" uniqKey="Hegermann J">J Hegermann</name></author><author><name sortKey="Brunner, B" uniqKey="Brunner B">B Brunner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niedenthal, Rk" uniqKey="Niedenthal R">RK Niedenthal</name></author><author><name sortKey="Riles, L" uniqKey="Riles L">L Riles</name></author><author><name sortKey="Johnston, M" uniqKey="Johnston M">M Johnston</name></author><author><name sortKey="Hegemann, Jh" uniqKey="Hegemann J">JH Hegemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madeo, F" uniqKey="Madeo F">F Madeo</name></author><author><name sortKey="Herker, E" uniqKey="Herker E">E Herker</name></author><author><name sortKey="Maldener, C" uniqKey="Maldener C">C Maldener</name></author><author><name sortKey="Wissing, S" uniqKey="Wissing S">S Wissing</name></author><author><name sortKey="L Chelt, S" uniqKey="L Chelt S">S Lächelt</name></author><author><name sortKey="Herlan, M" uniqKey="Herlan M">M Herlan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herker, E" uniqKey="Herker E">E Herker</name></author><author><name sortKey="Jungwirth, H" uniqKey="Jungwirth H">H Jungwirth</name></author><author><name sortKey="Lehmann, Ka" uniqKey="Lehmann K">KA Lehmann</name></author><author><name sortKey="Maldener, C" uniqKey="Maldener C">C Maldener</name></author><author><name sortKey="Frohlich, Ku" uniqKey="Frohlich K">KU Fröhlich</name></author><author><name sortKey="Wissing, S" uniqKey="Wissing S">S Wissing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttner, S" uniqKey="Buttner S">S Büttner</name></author><author><name sortKey="Eisenberg, T" uniqKey="Eisenberg T">T Eisenberg</name></author><author><name sortKey="Carmona Gutierrez, D" uniqKey="Carmona Gutierrez D">D Carmona-Gutierrez</name></author><author><name sortKey="Ruli, D" uniqKey="Ruli D">D Ruli</name></author><author><name sortKey="Knauer, H" uniqKey="Knauer H">H Knauer</name></author><author><name sortKey="Ruckenstuhl, C" uniqKey="Ruckenstuhl C">C Ruckenstuhl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kellermayer, R" uniqKey="Kellermayer R">R Kellermayer</name></author><author><name sortKey="Szigeti, R" uniqKey="Szigeti R">R Szigeti</name></author><author><name sortKey="Kellermayer, M" uniqKey="Kellermayer M">M Kellermayer</name></author><author><name sortKey="Miseta, A" uniqKey="Miseta A">A Miseta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, Ss" uniqKey="Gupta S">SS Gupta</name></author><author><name sortKey="Ton, Vk" uniqKey="Ton V">VK Ton</name></author><author><name sortKey="Beaudry, V" uniqKey="Beaudry V">V Beaudry</name></author><author><name sortKey="Rulli, S" uniqKey="Rulli S">S Rulli</name></author><author><name sortKey="Cunningham, K" uniqKey="Cunningham K">K Cunningham</name></author><author><name sortKey="Rao, R" uniqKey="Rao R">R Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenner, S" uniqKey="Brenner S">S Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiao, L" uniqKey="Qiao L">L Qiao</name></author><author><name sortKey="Hamamichi, S" uniqKey="Hamamichi S">S Hamamichi</name></author><author><name sortKey="Caldwell, Ka" uniqKey="Caldwell K">KA Caldwell</name></author><author><name sortKey="Caldwell, Ga" uniqKey="Caldwell G">GA Caldwell</name></author><author><name sortKey="Yacoubian, Ta" uniqKey="Yacoubian T">TA Yacoubian</name></author><author><name sortKey="Wilson, S" uniqKey="Wilson S">S Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Owald, D" uniqKey="Owald D">D Owald</name></author><author><name sortKey="Fouquet, W" uniqKey="Fouquet W">W Fouquet</name></author><author><name sortKey="Schmidt, M" uniqKey="Schmidt M">M Schmidt</name></author><author><name sortKey="Wichmann, C" uniqKey="Wichmann C">C Wichmann</name></author><author><name sortKey="Mertel, S" uniqKey="Mertel S">S Mertel</name></author><author><name sortKey="Depner, H" uniqKey="Depner H">H Depner</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001097 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001097 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:3569987
|texte= The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson's disease models
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:23154387" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |