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Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic

Identifieur interne : 004C03 ( Main/Exploration ); précédent : 004C02; suivant : 004C04

Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic

Auteurs : Rafi Ahmed [États-Unis] ; Michael B A. Oldstone [États-Unis] ; Peter Palese [États-Unis]

Source :

RBID : ISTEX:348DD5371524339254650108045A66E0BB9C8A83

Descripteurs français

English descriptors

Abstract

The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documented period between the ages of 4–13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.

Url:
DOI: 10.1038/ni1530


Affiliations:


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